Complete Publications List

2019 Publications

Mukherjee, S., Laiakis, E. C., Fornace, A. J., Jr. & Amundson, S. A. Impact of inflammatory signaling on radiation biodosimetry: mouse model of inflammatory bowel disease. BMC Genomics 20, 329, doi:10.1186/s12864-019-5689-y 2019 May 02. [BMC Genomics]
Ballas, L. K., Luo, C., Chung, E., Kishan, A. U., Shuryak, I., Quinn, D. I., Dorff, T., Jhimlee, S., Chiu, R., Abreu, A., Jennelle, R., Aron, M. & Groshen, S. Phase 1 Trial of SBRT to the Prostate Fossa After Prostatectomy. Int J Radiat Oncol Biol Phys 104, 50-60, doi:10.1016/j.ijrobp.2018.12.047 2019 May 01. [International Journal of Radiation Oncology*Biology*Physics]
Laiakis, E. C., Canadell, M. P., Grilj, V., Harken, A. D., Garty, G. Y., Astarita, G., Brenner, D. J., Smilenov, L. & Fornace, A. J., Jr. Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype. Sci Rep 9, 4539, doi:10.1038/s41598-019-41083-7 2019 Mar 14. [Scientific Reports]
Pujol-Canadell, M., Young, E. & Smilenov, L. Use of a Humanized Mouse Model System in the Validation of Human Radiation Biodosimetry Standards. Radiat Res, doi:10.1667/RR15283.1 2019 Feb 26. [Radiation Research]
Ivanov, V. N., Wu, J., Wang, T. J. C. & Hei, T. K. Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and gamma-irradiation in human glioblastoma cells. Oncotarget 10, 825-846, doi:10.18632/oncotarget.26582 2019 Feb 21. [Oncotarget]
Wang, Q., Rodrigues, M. A., Repin, M., Pampou, S., Beaton-Green, L. A., Perrier, J., Garty, G., Brenner, D. J., Turner, H. C. & Wilkins, R. C. Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay. Radiat Res, doi:10.1667/RR15243.1 2019 Feb 20. [Radiation Research]
Shuryak, I., Hall, E. J. & Brenner, D. J. Optimized Hypofractionation can Markedly Improve Tumor Control and Decrease Late Effects for Head and Neck Cancer. Int J Radiat Oncol Biol Phys, doi:10.1016/j.ijrobp.2019.02.025 2019 Feb 19. [International Journal of Radiation Oncology*Biology*Physics]
Schultzhaus, Z., Chen, A., Kim, S., Shuryak, I., Chang, M. & Wang, Z. Transcriptomic analysis reveals the relationship of melanization to growth and resistance to gamma radiation in Cryptococcus neoformans. Environ Microbiol, doi:10.1111/1462-2920.14550 2019 Feb 07. [Environmental Microbiology]
Shuryak, I. & Dadachova, E. Usefulness of continuous probability distributions of rates for modelling radionuclide biokinetics in humans and animals. Sci Rep 9, 1218, doi:10.1038/s41598-018-38046-9 2019 Feb 06. [Scientific Reports]
Beheshti, A., McDonald, J. T., Miller, J., Grabham, P. & Costes, S. V. GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species. Int J Mol Sci 20, doi:10.3390/ijms20030661 2019 Feb 06. [International Journal of Molecular Sciences]
Repin, M., Pampou, S., Garty, G. & Brenner, D. J. RABiT-II: A Fully-Automated Micronucleus Assay System with Shortened Time to Result. Radiat Res, doi:10.1667/RR15215.1 2019 Jan 19. [Radiation Research]
Guo, Z., Pei, H., Nie, J., Hu, W., Zhang, J., Ding, J., Pan, S., Li, B., Hei, T. K., Chen, W. & Zhou, G. Anti-cancer effects of CQBTO, a chloroquine and benzo(e)triazine oxide conjugate. Chem Biol Drug Des, doi:10.1111/cbdd.13477 2019 Jan 15. [Chemical Biology and Drug Design]

2018 Publications

Balajee, A. S., Escalona, M., Iddins, C. J., Shuryak, I., Livingston, G. K., Hanlon, D. & Dainiak, N. Development of electronic training and telescoring tools to increase the surge capacity of dicentric chromosome scorers for radiological/nuclear mass casualty incidents. Appl Radiat Isot 144, 111-117, doi:10.1016/j.apradiso.2018.12.005 (2018). [Appl Radiat Isot]
Amundson, S. A. Gene Expression Studies for the Development of Particle Therapy. Int J Part Ther 5, 49-59, doi:10.14338/IJPT-18-00010.1 (2018). [International Journal of Particle Therapy]
Shuryak, I. & Brenner, D. J. Mechanistic Modeling Predicts No Significant Dose Rate Effect on Heavy-Ion Carcinogenesis at Dose Rates Relevant for Space Exploration. Radiat Prot Dosimetry, doi:10.1093/rpd/ncy223 (2018). [Radiation Protection Dosimetry]
Barbieri, S., Baiocco, G., Babini, G., Morini, J., Friedland, W., Buonanno, M., Grilj, V., Brenner, D. J. & Ottolenghi, A. MODELLING gamma-H2AX FOCI INDUCTION TO MIMIC LIMITATIONS IN THE SCORING TECHNIQUE. Radiat Prot Dosimetry, doi:10.1093/rpd/ncy217 (2018). [Radiat Prot Dosimetry]
Pacelli, C., Bryan, R. A., Onofri, S., Selbmann, L., Zucconi, L., Shuryak, I. & Dadachova, E. Survival and redox activity of Friedmanniomyces endolithicus, an Antarctic endemic black meristematic fungus, after gamma rays exposure. Fungal Biol 122, 1222-1227, doi:10.1016/j.funbio.2018.10.002 (2018). [Fungal Biol]
Hu, W., Pei, W., Zhu, L., Nie, J., Pei, H., Zhang, J., Li, B., Hei, T. K. & Zhou, G. Microarray Profiling of TGF-beta1-Induced Long Non-Coding RNA Expression Patterns in Human Lung Bronchial Epithelial BEAS-2B Cells. Cell Physiol Biochem 50, 2071-2085, doi:10.1159/000495052 (2018). [Cell Physiol Biochem]
Shuryak, I. Review of microbial resistance to chronic ionizing radiation exposure under environmental conditions. J Environ Radioact 196, 50-63, doi:10.1016/j.jenvrad.2018.10.012 (2018). [J Environ Radioact]
Xu, R., Xu, Y., Huo, W., Lv, Z., Yuan, J., Ning, S., Wang, Q., Hou, M., Gao, G., Ji, J., Chen, J., Guo, R. & Xu, D. Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Proc Natl Acad Sci U S A, doi:10.1073/pnas.1806665115 (2018). [PNAS]
Broustas, C. G., Hopkins, K. M., Panigrahi, S. K., Wang, L., Virk, R. K. & Lieberman, H. B. RAD9A promotes metastatic phenotypes through transcriptional regulation of Anterior Gradient 2 (AGR2). Carcinogenesis, doi:10.1093/carcin/bgy131 (2018). [Carcinogenesis]
Lee, Y., Pujol Canadell, M., Shuryak, I., Perrier, J. R., Taveras, M., Patel, P., Koller, A., Smilenov, L. B., Brenner, D. J., Chen, E. I. & Turner, H. C. Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model. Sci Rep 8, 13557, doi:10.1038/s41598-018-31740-8 (2018). [Scientific Reports]
Vladar, E. K., Stratton, M. B., Saal, M. L., Salazar-De Simone, G., Wang, X., Wolgemuth, D., Stearns, T. & Axelrod, J. D. Cyclin-dependent kinase control of motile ciliogenesis. Elife 7, doi:10.7554/eLife.36375 (2018). [eLife]
Hu, W., Pei, H., Sun, F., Li, P., Nie, J., Li, B., Hei, T. K. & Zhou, G. Epithelial-mesenchymal transition in non-targeted lung tissues of Kunming mice exposed to X-rays is suppressed by celecoxib. J Radiat Res 59, 583-587, doi:10.1093/jrr/rry050 (2018). [Journal of Radiation Research]
An, L., Dong, C., Li, J., Chen, J., Yuan, J., Huang, J., Chan, K. M., Yu, C. H. & Huen, M. S. Y. RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair. Proc Natl Acad Sci U S A 115, E8286-E8295, doi:10.1073/pnas.1804823115 (2018). [PNAS]
Welch, D., Buonanno, M., Shuryak, I., Randers-Pehrson, G., Spotnitz, H. M. & Brenner, D. J. Effect of far ultraviolet light emitted from an optical diffuser on methicillin-resistant Staphylococcus aureus in vitro. PLoS One 13, e0202275, doi:10.1371/journal.pone.0202275 (2018). [PLOS]
Lieberman, H. B., Rai, A. J., Friedman, R. A., Hopkins, K. M. & Broustas, C. G. Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management. Transl Cancer Res 7, S651-S661, doi:10.21037/tcr.2018.01.21 (2018). [Translational Cancer Research]
Chen, H., Pei, H., Hu, W., Ma, J., Zhang, J., Mao, W., Nie, J., Xu, C., Li, B., Hei, T. K., Wang, C. & Zhou, G. Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A. J Cancer 9, 2580-2588, doi:10.7150/jca.24896 (2018). [Journal of Cancer]
Broustas, C. G., Harken, A. D., Garty, G. & Amundson, S. A. Identification of differentially expressed genes and pathways in mice exposed to mixed field neutron/photon radiation. BMC Genomics 19, 504, doi:10.1186/s12864-018-4884-6 (2018). [BMC Genomics]
Pei, H., Hu, W., Guo, Z., Chen, H., Ma, J., Mao, W., Li, B., Wang, A., Wan, J., Zhang, J., Nie, J., Zhou, G. & Hei, T. K. Long Noncoding RNA CRYBG3 Blocks Cytokinesis by Directly Binding G-Actin. Cancer Res 78, 4563-4572, doi:10.1158/0008-5472.CAN-18-0988 (2018). [Cancer Research]
Calaf, G. M., Aguayo, F., Sergi, C. M., Juarranz, A. & Roy, D. Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer. Oxid Med Cell Longev 2018, 5363064, doi:10.1155/2018/5363064 (2018). [Oxidative Medicine and Cellular Longevity]
Shuryak, I. Modeling species richness and abundance of phytoplankton and zooplankton in radioactively contaminated water bodies. J Environ Radioact 192, 14-25, doi:10.1016/j.jenvrad.2018.05.016 (2018). [Journal of Environmental Radioactivity]
Lacombe, J., Sima, C., Amundson, S. A. & Zenhausern, F. Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review. PLoS One 13, e0198851, doi:10.1371/journal.pone.0198851 (2018). [PLOS]
Einstein, A. J., Shuryak, I., Castano, A., Mintz, A., Maurer, M. S. & Bokhari, S. Estimating cancer risk from (99m)Tc pyrophosphate imaging for transthyretin cardiac amyloidosis. J Nucl Cardiol, doi:10.1007/s12350-018-1307-7 (2018). [Journal of Nuclear Cardiology]
Calaf, G. M., Urzua, U., Termini, L. & Aguayo, F. Oxidative stress in female cancers. Oncotarget 9, 23824-23842, doi:10.18632/oncotarget.25323 (2018). [Oncotarget]
Balajee, A. S., Sanders, J. T., Golloshi, R., Shuryak, I., McCord, R. P. & Dainiak, N. Investigation of Spatial Organization of Chromosome Territories in Chromosome Exchange Aberrations After Ionizing Radiation Exposure. Health Phys 115, 77-89, doi:10.1097/HP.0000000000000840 (2018). [Health Physics]
Suresh Kumar, M. A., Laiakis, E. C., Ghandhi, S. A., Morton, S. R., Fornace, A. J., Jr. & Amundson, S. A. Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays. Radiat Res 190, 53-62, doi:10.1667/RR14990.1 (2018). [Radiation Research]
Shuryak, I., Hall, E. J. & Brenner, D. J. Dose dependence of accelerated repopulation in head and neck cancer: Supporting evidence and clinical implications. Radiother Oncol 127, 20-26, doi:10.1016/j.radonc.2018.02.015 (2018). [Radiotherapy and Oncology]
Brenner, D. J. & Hall, E. J. Are We Now Able to Define Guidelines for Moderate Hypofractionation in Prostate Cancer Radiation Therapy? Int J Radiat Oncol Biol Phys 100, 871-873, doi:10.1016/j.ijrobp.2017.12.274 (2018). [International Journal of Radiation Oncology*Biology*Physics]
Pacelli, C., Bryan, R. A., Onofri, S., Selbmann, L., Zucconi, L., Shuryak, I. & Dadachova, E. The effect of protracted X-ray exposure on cell survival and metabolic activity of fast and slow growing fungi capable of melanogenesis. Environ Microbiol Rep 10, 255-263, doi:10.1111/1758-2229.12632 (2018). [Environmental Microbiology Reports]
Ponnaiya, B., Buonanno, M., Welch, D., Shuryak, I., Randers-Pehrson, G. & Brenner, D. J. Far-UVC light prevents MRSA infection of superficial wounds in vivo. PLoS One 13, e0192053, doi:10.1371/journal.pone.0192053 (2018). [PLOS]
Welch, D., Buonanno, M., Grilj, V., Shuryak, I., Crickmore, C., Bigelow, A. W., Randers-Pehrson, G., Johnson, G. W. & Brenner, D. J. Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases. Sci Rep 8, 2752, doi:10.1038/s41598-018-21058-w (2018). [Scientific Reports]
Ghandhi, S. A., Turner, H. C., Shuryak, I., Dugan, G. O., Bourland, J. D., Olson, J. D., Tooze, J. A., Morton, S. R., Batinic-Haberle, I., Cline, J. M. & Amundson, S. A. Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. PLoS One 13, e0191402, doi:10.1371/journal.pone.0191402 (2018). [PLOS]
Rudqvist, N., Laiakis, E. C., Ghandhi, S. A., Kumar, S., Knotts, J. D., Chowdhury, M., Fornace, A. J., Jr. & Amundson, S. A. Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation. Radiat Res 189, 337-344, doi:10.1667/RR14862.1 (2018). [Radiation Research]
Trattner, S., Halliburton, S., Thompson, C. M., Xu, Y., Chelliah, A., Jambawalikar, S. R., Peng, B., Peters, M. R., Jacobs, J. E., Ghesani, M., Jang, J. J., Al-Khalidi, H. & Einstein, A. J. Cardiac-Specific Conversion Factors to Estimate Radiation Effective Dose From Dose-Length Product in Computed Tomography. JACC Cardiovasc Imaging 11, 64-74, doi:10.1016/j.jcmg.2017.06.006 (2018). [JACC Cardiovascular Imaging]
Wu, J. & Hei, T. K. Focus small to find big - the microbeam story. Int J Radiat Biol 94, 782-788, doi:10.1080/09553002.2017.1364801 (2018). [International Journal of Radiation Biology]

2017 Publications

England, M. J., Bigelow, A. W., Merchant, M. J., Velliou, E., Welch, D., Brenner, D. J. & Kirkby, K. J. Automated microbeam observation environment for biological analysis-Custom portable environmental control applied to a vertical microbeam system. Sens Actuators B Chem 239, 1134-1143, doi:10.1016/j.snb.2016.08.076 (2017). [Sensors and Actuators B: Chemical]
Shuryak, I., Loucas, B. D. & Cornforth, M. N. Straightening Beta: Overdispersion of Lethal Chromosome Aberrations following Radiotherapeutic Doses Leads to Terminal Linearity in the Alpha-Beta Model. Front Oncol 7, 318, doi:10.3389/fonc.2017.00318 (2017). [Frontiers in Oncology]
Shuryak, I., Matrosova, V. Y., Gaidamakova, E. K., Tkavc, R., Grichenko, O., Klimenkova, P., Volpe, R. P. & Daly, M. J. Microbial cells can cooperate to resist high-level chronic ionizing radiation. PLoS One 12, e0189261, doi:10.1371/journal.pone.0189261 (2017). [PLOS]
Kleiman, N. J., Stewart, F. A. & Hall, E. J. Modifiers of radiation effects in the eye. Life Sci Space Res (Amst) 15, 43-54, doi:10.1016/j.lssr.2017.07.005 (2017). [Life Sciences in Space Research]
Carrillo, D., Munoz, J. P., Huerta, H., Leal, G., Corvalan, A., Leon, O., Calaf, G. M., Urzua, U., Boccardo, E., Tapia, J. C. & Aguayo, F. Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells. Open Biol 7, doi:10.1098/rsob.170111 (2017). [Open Biology]
Ivanov, V. N., Wu, J. & Hei, T. K. Regulation of human glioblastoma cell death by combined treatment of cannabidiol, gamma-radiation and small molecule inhibitors of cell signaling pathways. Oncotarget 8, 74068-74095, doi:10.18632/oncotarget.18240 (2017). [Oncotarget]
Sharma, A., Gaidamakova, E. K., Grichenko, O., Matrosova, V. Y., Hoeke, V., Klimenkova, P., Conze, I. H., Volpe, R. P., Tkavc, R., Gostincar, C., Gunde-Cimerman, N., DiRuggiero, J., Shuryak, I., Ozarowski, A., Hoffman, B. M. & Daly, M. J. Across the tree of life, radiation resistance is governed by antioxidant Mn(2+), gauged by paramagnetic resonance. Proc Natl Acad Sci U S A 114, E9253-E9260, doi:10.1073/pnas.1713608114 (2017). [PNAS]
Miller, A. C., Gilstad, J. & Brenner, D. J. Military Global Health Engagement and Low-Dose Ionizing Radiation. Mil Med 182, 1677-1679, doi:10.7205/MILMED-D-17-00142 (2017). [Military Medicine]
Wu, C. C., Chaudhary, K. R., Na, Y. H., Welch, D., Black, P. J., Sonabend, A. M., Canoll, P., Saenger, Y. M., Wang, T. J. C., Wuu, C. S., Hei, T. K. & Cheng, S. K. Quality Assessment of Stereotactic Radiosurgery of a Melanoma Brain Metastases Model Using a Mouselike Phantom and the Small Animal Radiation Research Platform. Int J Radiat Oncol Biol Phys 99, 191-201, doi:10.1016/j.ijrobp.2017.05.016 (2017). [International Journal of Radiation Oncology*Biology*Physics]
Miller, A. C., Rivas, R., Tesoro, L., Kovalenko, G., Kovaric, N., Pavlovic, P. & Brenner, D. Radiation exposure from depleted uranium: The radiation bystander effect. Toxicol Appl Pharmacol 331, 135-141, doi:10.1016/j.taap.2017.06.004 (2017). [Toxicology and Applied Pharmacology]
Welch, D., Spotnitz, H. M. & Brenner, D. J. Measurement of UV Emission from a Diffusing Optical Fiber Using Radiochromic Film. Photochem Photobiol 93, 1509-1512, doi:10.1111/php.12798 (2017). [Photochemistry and Photobiology]
Rivas, M., Rojas, E., Calaf, G. M., Barberan, M., Liberman, C. & De Paula Correa, M. Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude. Oncol Lett 13, 3787-3792, doi:10.3892/ol.2017.5898 (2017). [Oncology Letters]
Nagel, Z. D., Engelward, B. P., Brenner, D. J., Begley, T. J., Sobol, R. W., Bielas, J. H., Stambrook, P. J., Wei, Q., Hu, J. J., Terry, M. B., Dilworth, C., McAllister, K. A., Reinlib, L., Worth, L. & Shaughnessy, D. T. Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Mutat Res 800-802, 14-28, doi:10.1016/j.mrfmmm.2017.03.007 (2017). [Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis]
Shuryak, I. Quantitative modeling of responses to chronic ionizing radiation exposure using targeted and non-targeted effects. PLoS One 12, e0176476, doi:10.1371/journal.pone.0176476 (2017). [PLOS]
Welch, D., Randers-Pehrson, G., Spotnitz, H. M. & Brenner, D. J. Unlaminated Gafchromic Ebt3 Film for Ultraviolet Radiation Monitoring. Radiat Prot Dosimetry 176, 341-346, doi:10.1093/rpd/ncx016 (2017). [Radiation Protection Dosimetry]
Wu, J., Zhang, B., Wuu, Y. R., Davidson, M. M. & Hei, T. K. Targeted cytoplasmic irradiation and autophagy. Mutat Res 806, 88-97, doi:10.1016/j.mrfmmm.2017.02.004 (2017). [Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis]
Repin, M., Pampou, S., Karan, C., Brenner, D. J. & Garty, G. RABiT-II: Implementation of a High-Throughput Micronucleus Biodosimetry Assay on Commercial Biotech Robotic Systems. Radiat Res 187, 492-498, doi:10.1667/RR011CC.1 (2017). [Radiation Research]
Buonanno, M., Ponnaiya, B., Welch, D., Stanislauskas, M., Randers-Pehrson, G., Smilenov, L., Lowy, F. D., Owens, D. M. & Brenner, D. J. Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light. Radiat Res 187, 483-491, doi:10.1667/RR0010CC.1 (2017). [Radiation Research]
Shuryak, I., Fornace, A. J., Jr., Datta, K., Suman, S., Kumar, S., Sachs, R. K. & Brenner, D. J. Scaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex. Radiat Res 187, 476-482, doi:10.1667/RR009CC.1 (2017). [Radiation Research]
Wu, J., Zhang, Q., Wuu, Y. R., Zou, S. & Hei, T. K. Cytoplasmic Irradiation Induces Metabolic Shift in Human Small Airway Epithelial Cells via Activation of Pim-1 Kinase. Radiat Res 187, 441-453, doi:10.1667/RR0006CC.1 (2017). [Radiation Research]
Li, X., Gao, M., Choi, J. M., Kim, B. J., Zhou, M. T., Chen, Z., Jain, A. N., Jung, S. Y., Yuan, J., Wang, W., Wang, Y. & Chen, J. Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics 16, 594-607, doi:10.1074/mcp.M116.064543 (2017). [Molecular & Cellular Proteomics]
Welch, D., Turner, L., Speiser, M., Randers-Pehrson, G. & Brenner, D. J. Scattered Dose Calculations and Measurements in a Life-Like Mouse Phantom. Radiat Res 187, 433-442, doi:10.1667/RR004CC.1 (2017). [Radiation Research]
Lieberman, H. B., Panigrahi, S. K., Hopkins, K. M., Wang, L. & Broustas, C. G. p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks. Radiat Res 187, 424-432, doi:10.1667/RR003CC.1 (2017). [Radiation Research]
Hall, E. J. 100 Years of Radiation Research in the Footsteps of Failla. Radiat Res, doi:10.1667/RR001CC (2017). [Radiation Research]
Broustas, C. G., Xu, Y., Harken, A. D., Chowdhury, M., Garty, G. & Amundson, S. A. Impact of Neutron Exposure on Global Gene Expression in a Human Peripheral Blood Model. Radiat Res 187, 433-440, doi:10.1667/RR0005.1 (2017). [Radiation Research]
Pacelli, C., Bryan, R. A., Onofri, S., Selbmann, L., Shuryak, I. & Dadachova, E. Melanin is effective in protecting fast and slow growing fungi from various types of ionizing radiation. Environ Microbiol 19, 1612-1624, doi:10.1111/1462-2920.13681 (2017). [Environmental Microbiology]
Trattner, S., Chelliah, A., Prinsen, P., Ruzal-Shapiro, C. B., Xu, Y., Jambawalikar, S., Amurao, M. & Einstein, A. J. Estimating Effective Dose of Radiation From Pediatric Cardiac CT Angiography Using a 64-MDCT Scanner: New Conversion Factors Relating Dose-Length Product to Effective Dose. AJR Am J Roentgenol 208, 585-594, doi:10.2214/AJR.15.15908 (2017). [American Journal of Roentgenology]
Shuryak, I., Loucas, B. D. & Cornforth, M. N. Seeking Beta: Experimental Considerations and Theoretical Implications Regarding the Detection of Curvature in Dose-Response Relationships for Chromosome Aberrations. Radiat Res 187, 7-19, doi:10.1667/RR14520.1 (2017). [Radiation Research]
Shuryak, I. Advantages of Synthetic Noise and Machine Learning for Analyzing Radioecological Data Sets. PLoS One 12, e0170007, doi:10.1371/journal.pone.0170007 (2017). [PLOS]
Broustas, C. G., Xu, Y., Harken, A. D., Garty, G. & Amundson, S. A. Comparison of gene expression response to neutron and x-ray irradiation using mouse blood. BMC Genomics 18, 2, doi:10.1186/s12864-016-3436-1 (2017). [BMC Genomics]
Holmes, J. A., Chera, B. S., Brenner, D. J., Shuryak, I., Wilson, A. K., Lehman-Davis, M., Fried, D. V., Somasundaram, V., Lian, J., Cullip, T. & Marks, L. B. Estimating the excess lifetime risk of radiation induced secondary malignancy (SMN) in pediatric patients treated with craniospinal irradiation (CSI): Conventional radiation therapy versus helical intensity modulated radiation therapy. Pract Radiat Oncol 7, 35-41, doi:10.1016/j.prro.2016.07.002 (2017). [Practical Radiation Oncology]

2016 Publications

Gong, X., Duan, Y., Zheng, J., Wang, Y., Wang, G., Norgren, S. & Hei, T. K. Neproprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats. Oxid Med Cell Longev 2016, 8715185, doi:10.1155/2016/8715185 (2016). [Oxidative Medicine and Cellular Longevity]
Templin, T., Sharma, P., Guida, P. & Grabham, P. Short-Term Effects of Low-LET Radiation on the Endothelial Barrier: Uncoupling of PECAM-1 and the Production of Endothelial Microparticles. Radiat Res 186, 602-613, doi:10.1667/RR14510.1 (2016). [Radiation Research]
Durante, M., Brenner, D. J. & Formenti, S. C. Does Heavy Ion Therapy Work Through the Immune System? Int J Radiat Oncol Biol Phys 96, 934-936, doi:10.1016/j.ijrobp.2016.08.037 (2016). [International Journal of Radiation Oncology*Biology*Physics]
Lee, Y. C., Zhou, Q., Chen, J. & Yuan, J. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Curr Biol 26, 3257-3268, doi:10.1016/j.cub.2016.10.030 (2016). [Current Biology]
Chen, Z., Liu, X. & Ma, S. The Roles of Mitochondria in Autophagic Cell Death. Cancer Biother Radiopharm 31, 269-276, doi:10.1089/cbr.2016.2057 (2016). [Cancer Biotherapy and Radiopharmaceuticals]
Bian, D., Tsui, J. C., Repin, M., Garty, G., Turner, H., Lawrence Yao, Y. & Brenner, D. J. Liquid Handling Optimization in High-Throughput Biodosimetry Tool. J Med Device 10, 0410071-4100710, doi:10.1115/1.4033600 (2016). [Journal of Medical Devices]
Liang, B., Liu, X., Liu, Y., Kong, D., Liu, X., Zhong, R. & Ma, S. Inhibition of autophagy sensitizes MDR-phenotype ovarian cancer SKVCR cells to chemotherapy. Biomed Pharmacother 82, 98-105, doi:10.1016/j.biopha.2016.04.054 (2016). [Biomedicine and Pharmacotherapy]
Garty, G., Turner, H. C., Salerno, A., Bertucci, A., Zhang, J., Chen, Y., Dutta, A., Sharma, P., Bian, D., Taveras, M., Wang, H., Bhatla, A., Balajee, A., Bigelow, A. W., Repin, M., Lyulko, O. V., Simaan, N., Yao, Y. L. & Brenner, D. J. THE DECADE OF THE RABiT (2005-15). Radiat Prot Dosimetry 172, 201-206, doi:10.1093/rpd/ncw172 (2016). [Radiation Protection Dosimetry]
Buonanno, M., Stanislauskas, M., Ponnaiya, B., Bigelow, A. W., Randers-Pehrson, G., Xu, Y., Shuryak, I., Smilenov, L., Owens, D. M. & Brenner, D. J. 207-nm UV Light-A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. II: In-Vivo Safety Studies. PLoS One 11, e0138418, doi:10.1371/journal.pone.0138418 (2016). [PLOS]
Goudarzi, M., Chauthe, S., Strawn, S. J., Weber, W. M., Brenner, D. J. & Fornace, A. J. Quantitative Metabolomic Analysis of Urinary Citrulline and Calcitroic Acid in Mice after Exposure to Various Types of Ionizing Radiation. Int J Mol Sci 17, doi:10.3390/ijms17050782 (2016). [International Journal of Molecular Sciences]
Fang, Z., Xu, A., Wu, L., Hei, T. K. & Hong, M. The role of protein kinase C alpha translocation in radiation-induced bystander effect. Sci Rep 6, 25817, doi:10.1038/srep25817 (2016). [Scientific Reports]
Loucas, B. D., Shuryak, I. & Cornforth, M. N. Three-Color Chromosome Painting as Seen through the Eyes of mFISH: Another Look at Radiation-Induced Exchanges and Their Conversion to Whole-Genome Equivalency. Front Oncol 6, 52, doi:10.3389/fonc.2016.00052 (2016). [Frontiers in Oncology]
Bao, L., Ma, J., Chen, G., Hou, J., Hei, T. K., Yu, K. N. & Han, W. Role of heme Oxygenase-1 in low dose Radioadaptive response. Redox Biol 8, 333-340, doi:10.1016/j.redox.2016.03.002 (2016). [Redox Biology]
Shuryak, I., Sun, Y. & Balajee, A. S. Advantages of Binomial Likelihood Maximization for Analyzing and Modeling Cell Survival Curves. Radiat Res 185, 246-256, doi:10.1667/RR14195.1 (2016). [Radiation Research]
Liu, Y., Wang, X., Wang, J., Nie, Y., Du, H., Dai, H., Wang, J., Wang, M., Chen, S., Hei, T. K., Deng, Z., Wu, L. & Xu, A. Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy. Environ Sci Technol 50, 3154-3164, doi:10.1021/acs.est.5b03895 (2016). [Environmental Science and Technology]
Shuryak, I. & Dadachova, E. Quantitative Modeling of Microbial Population Responses to Chronic Irradiation Combined with Other Stressors. PLoS One 11, e0147696, doi:10.1371/journal.pone.0147696 (2016). [PLOS]
Hei, T. K. Response of Biological Systems to Low Doses of Ionizing Radiation. Health Phys 110, 281-282, doi:10.1097/HP.0000000000000452 (2016). [Health Physics]
Bertucci, A., Smilenov, L. B., Turner, H. C., Amundson, S. A. & Brenner, D. J. In vitro RABiT measurement of dose rate effects on radiation induction of micronuclei in human peripheral blood lymphocytes. Radiat Environ Biophys 55, 53-59, doi:10.1007/s00411-015-0628-z (2016). [Radiation and Environmental Biophysics]
Shuryak, I. Mechanistic Modeling of Dose and Dose Rate Dependences of Radiation-Induced DNA Double Strand Break Rejoining Kinetics in Saccharomyces cerevisiae. PLoS One 11, e0146407, doi:10.1371/journal.pone.0146407 (2016). [PLOS]
Radivoyevitch, T., Sachs, R. K., Gale, R. P., Molenaar, R. J., Brenner, D. J., Hill, B. T., Kalaycio, M. E., Carraway, H. E., Mukherjee, S., Sekeres, M. A. & Maciejewski, J. P. Defining AML and MDS second cancer risk dynamics after diagnoses of first cancers treated or not with radiation. Leukemia 30, 285-294, doi:10.1038/leu.2015.258 (2016). [Nature]
Gong, X., Ivanov, V. N. & Hei, T. K. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol 90, 2187-2200, doi:10.1007/s00204-015-1600-z (2016). [Archives of Toxicology]

2015 Publications

Sun, H., Olsen, T., Zhu, J., Tao, J., Ponnaiya, B., Amundson, S. A., Brenner, D. J. & Lin, Q. A microfluidic approach to parallelized transcriptional profiling of single cells. Microfluid Nanofluidics 19, 1429-1440, doi:10.1007/s10404-015-1657-2 (2015). [Royal Society of Chemistry]
Turner, H. C., Shuryak, I., Weber, W., Doyle-Eisele, M., Melo, D., Guilmette, R., Amundson, S. A. & Brenner, D. J. gamma-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90. PLoS One 10, e0143815, doi:10.1371/journal.pone.0143815 (2015). [PLOS]
Sweasy, J. B., Lieberman, H. B., Volkert, M. & George, D. Evelyn Witkin and the coordinated response to DNA damage. DNA Repair (Amst) 35, 154-155, doi:10.1016/j.dnarep.2015.10.005 (2015). [DNA Repair]
Liu, L., Huang, J., Wang, K., Li, L., Li, Y., Yuan, J. & Wei, S. Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing. Oncotarget 6, 38016-38028, doi:10.18632/oncotarget.5697 (2015). [Oncotarget]
Brenner, D. J. Should we worry about inherited radiation risks? Lancet Oncol 16, 1275-1276, doi:10.1016/S1470-2045(15)00270-3 (2015). [The Lancet]
Wang, T. J., Wu, C. C., Chai, Y., Lam, R. K., Hamada, N., Kakinuma, S., Uchihori, Y., Yu, P. K. & Hei, T. K. Induction of Non-Targeted Stress Responses in Mammary Tissues by Heavy Ions. PLoS One 10, e0136307, doi:10.1371/journal.pone.0136307 (2015). [PLOS]
Goudarzi, M., Weber, W. M., Chung, J., Doyle-Eisele, M., Melo, D. R., Mak, T. D., Strawn, S. J., Brenner, D. J., Guilmette, R. & Fornace, A. J., Jr. Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography-Mass Spectrometry Approach. J Proteome Res 14, 4039-4049, doi:10.1021/acs.jproteome.5b00576 (2015). [Journal of Proteome Research]
Ghandhi, S. A., Weber, W., Melo, D., Doyle-Eisele, M., Chowdhury, M., Guilmette, R. & Amundson, S. A. Effect of 90Sr internal emitter on gene expression in mouse blood. BMC Genomics 16, 586, doi:10.1186/s12864-015-1774-z (2015). [BMC Genomics]
Lue, S. W., Repin, M., Mahnke, R. & Brenner, D. J. Development of a High-Throughput and Miniaturized Cytokinesis-Block Micronucleus Assay for Use as a Biological Dosimetry Population Triage Tool. Radiat Res 184, 134-142, doi: 10.1667/RR13991.1 (2015). [Radiation Research]
Suresh Kumar, M. A., Peluso, M., Chaudhary, P., Dhawan, J., Beheshti, A., Manickam, K., Thapar, U., Pena, L., Natarajan, M., Hlatky, L., Demple, B. & Naidu, M. Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1. PLoS One 10, e0133016, doi:10.1371/journal.pone.0133016 (2015). [PLOS]
Shuryak, I. & Dadachova, E. New Approaches for Modeling Radiopharmaceutical Pharmacokinetics Using Continuous Distributions of Rates. J Nucl Med 56, 1622-1628, doi:10.2967/jnumed.115.160515 (2015). [Journal of Nuclear Medicine]
Paul, S., Smilenov, L. B., Elliston, C. D. & Amundson, S. A. Radiation Dose-Rate Effects on Gene Expression in a Mouse Biodosimetry Model. Radiat Res 184, 24-32, doi:10.1667/RR14044.1 (2015). [Radiation Research]
Nahta, R., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Andrade-Vieira, R., Bay, S. N., Brown, D. G., Calaf, G. M., Castellino, R. C., Cohen-Solal, K. A., Colacci, A., Cruickshanks, N., Dent, P., Di Fiore, R., Forte, S., Goldberg, G. S., Hamid, R. A., Krishnan, H., Laird, D. W., Lasfar, A., Marignani, P. A., Memeo, L., Mondello, C., Naus, C. C., Ponce-Cusi, R., Raju, J., Roy, D., Roy, R., Ryan, E. P., Salem, H. K., Scovassi, A. I., Singh, N., Vaccari, M., Vento, R., Vondracek, J., Wade, M., Woodrick, J. & Bisson, W. H. Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis 36 Suppl 1, S2-18, doi:10.1093/carcin/bgv028 (2015). [Carcinogenesis]
Brenner, D. J., Chao, N. J., Greenberger, J. S., Guha, C., McBride, W. H., Swartz, H. M. & Williams, J. P. Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network. Int J Radiat Oncol Biol Phys 92, 504-505, doi:10.1016/j.ijrobp.2015.02.042 (2015). [International Journal of Radiation Oncology*Biology*Physics]
Shuryak, I., Carlson, D. J., Brown, J. M. & Brenner, D. J. High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients. Radiother Oncol 115, 327-334, doi:10.1016/j.radonc.2015.05.013 (2015). [Radiotherapy and Oncology]
Nicolai, S., Filippi, S., Caputo, M., Cipak, L., Gregan, J., Ammerer, G., Frontini, M., Willems, D., Prantera, G., Balajee, A. S. & Proietti-De-Santis, L. Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. PLoS One 10, e0128558, doi:10.1371/journal.pone.0128558 (2015). [PLOS]
Liu, J., Fang, H., Chi, Z., Wu, Z., Wei, D., Mo, D., Niu, K., Balajee, A. S., Hei, T. K., Nie, L. & Zhao, Y. XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage. Nucleic Acids Res 43, 5476-5488, doi:10.1093/nar/gkv472 (2015). [Nucleic Acids Research]
Ghandhi, S. A., Smilenov, L. B., Elliston, C. D., Chowdhury, M. & Amundson, S. A. Radiation dose-rate effects on gene expression for human biodosimetry. BMC Med Genomics 8, 22, doi:10.1186/s12920-015-0097-x (2015). [BMC Medical Genomics]
Ivanov, V. N. & Hei, T. K. Regulation of viability, differentiation and death of human melanoma cells carrying neural stem cell biomarkers: a possibility for neural trans-differentiation. Apoptosis 20, 996-1015, doi:10.1007/s10495-015-1131-3 (2015). [Apoptosis]
Garty, G., Bigelow, A. W., Repin, M., Turner, H. C., Bian, D., Balajee, A. S., Lyulko, O. V., Taveras, M., Yao, Y. L. & Brenner, D. J. An automated imaging system for radiation biodosimetry. Microsc Res Tech 78, 587-598, doi:10.1002/jemt.22512 (2015). [Microscopy Research and Technique]
Lee, Y. H., Sun, Y., Gerweck, L. E. & Glickman, R. D. Regulation of DNA Damage Response by Estrogen Receptor beta-Mediated Inhibition of Breast Cancer Associated Gene 2. Biomedicines 3, 182-200, doi:10.3390/biomedicines3020182 (2015). [Biomedicines]
Xue, G., Ren, Z., Grabham, P. W., Chen, Y., Zhu, J., Du, Y., Pan, D., Li, X. & Hu, B. Reprogramming mediated radio-resistance of 3D-grown cancer cells. J Radiat Res 56, 656-662, doi:10.1093/jrr/rrv018 (2015). [Journal of Radiation Research]
Sun, H., Olsen, T., Zhu, J., Tao, J., Ponnaiya, B., Amundson, S. A., Brenner, D. J. & Lin, Q. A Bead-Based Microfluidic Approach to Integrated Single-Cell Gene Expression Analysis by Quantitative RT-PCR. RSC Adv 5, 4886-4893, doi:10.1039/C4RA13356K (2015). [Royal Society of Chemistry]
Panigrahi, S. K., Hopkins, K. M. & Lieberman, H. B. Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair. Nucleic Acids Res 43, 4531-4546, doi:10.1093/nar/gkv327 (2015). [Nucleic Acids Research]
Welch, D., Harken, A. D., Randers-Pehrson, G. & Brenner, D. J. Construction of mouse phantoms from segmented CT scan data for radiation dosimetry studies. Phys Med Biol 60, 3589-3598, doi:10.1088/0031-9155/60/9/3589 (2015). [Physics in Medicine and Biology]
Shuryak, I., Bryan, R. A., Broitman, J., Marino, S. A., Morgenstern, A., Apostolidis, C. & Dadachova, E. Effects of radiation type and delivery mode on a radioresistant eukaryote Cryptococcus neoformans. Nucl Med Biol 42, 515-523, doi:10.1016/j.nucmedbio.2015.02.006 (2015). [Nuclear Medicine and Biology]
Sharma, P. M., Ponnaiya, B., Taveras, M., Shuryak, I., Turner, H. & Brenner, D. J. High throughput measurement of gammaH2AX DSB repair kinetics in a healthy human population. PLoS One 10, e0121083, doi:10.1371/journal.pone.0121083 (2015). [PLOS]
Wang, X., Huang, P., Liu, Y., Du, H., Wang, X., Wang, M., Wang, Y., Hei, T. K., Wu, L. & Xu, A. Role of nitric oxide in the genotoxic response to chronic microcystin-LR exposure in human-hamster hybrid cells. J Environ Sci (China) 29, 210-218, doi:10.1016/j.jes.2014.07.036 (2015). [Journal of Environmental Sciences]
Turner, H. C., Shuryak, I., Taveras, M., Bertucci, A., Perrier, J. R., Chen, C., Elliston, C. D., Johnson, G. W., Smilenov, L. B., Amundson, S. A. & Brenner, D. J. Effect of dose rate on residual gamma-H2AX levels and frequency of micronuclei in X-irradiated mouse lymphocytes. Radiat Res 183, 315-324, doi:10.1667/RR13860.1 (2015). [Radiation Research]
Wang, M. M., Wang, Y. C., Wang, X. N., Liu, Y., Zhang, H., Zhang, J. W., Huang, Q., Chen, S. P., Hei, T. K., Wu, L. J. & Xu, A. Mutagenicity of ZnO nanoparticles in mammalian cells: Role of physicochemical transformations under the aging process. Nanotoxicology 9, 972-982, doi:10.3109/17435390.2014.992816 (2015). [Nanotoxicology]
Roy, D. & Calaf, G. M. Mutation of beta-catenin in a radiation and estrogen breast cancer model. Int J Oncol 46, 153-160, doi:10.3892/ijo.2014.2722 (2015). [International Journal of Oncology]
Xu, Y., Zhang, B., Messerli, M., Randers-Pehrson, G., Hei, T. K. & Brenner, D. J. Metabolic oxygen consumption measurement with a single-cell biosensor after particle microbeam irradiation. Radiat Environ Biophys 54, 137-144, doi:10.1007/s00411-014-0574-1 (2015). [Radiation and Environmental Biophysics]
Gong, X., Ivanov, V. N., Davidson, M. M. & Hei, T. K. Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death. Arch Toxicol 89, 1057-1070, doi:10.1007/s00204-014-1302-y (2015). [Archives of Toxicology]

2014 Publications

Paul, S. & Amundson, S. A. Differential Effect of Active Smoking on Gene Expression in Male and Female Smokers. J Carcinog Mutagen 5, doi:10.4172/2157-2518.1000198 (2014). [Journal of Carcinogenesis and Mutagenesis]
Ivanov, V. N. & Hei, T. K. Radiation-induced glioblastoma signaling cascade regulates viability, apoptosis and differentiation of neural stem cells (NSC). Apoptosis 19, 1736-1754, doi:10.1007/s10495-014-1040-x (2014). [Apoptosis]
Ghandhi, S. A., Ponnaiya, B., Panigrahi, S. K., Hopkins, K. M., Cui, Q., Hei, T. K., Amundson, S. A. & Lieberman, H. B. RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response. Radiat Oncol 9, 206, doi:10.1186/1748-717X-9-206 (2014). [BMC Radiation Oncology]
Balajee, A. S., Bertucci, A., Taveras, M. & Brenner, D. J. Multicolour FISH analysis of ionising radiation induced micronucleus formation in human lymphocytes. Mutagenesis 29, 447-455, doi:10.1093/mutage/geu041 (2014). [Mutagenesis]
Paul, S., Ghandhi, S. A., Weber, W., Doyle-Eisele, M., Melo, D., Guilmette, R. & Amundson, S. A. Gene expression response of mice after a single dose of 137CS as an internal emitter. Radiat Res 182, 380-389, doi:10.1667/RR13466.1 (2014). [Radiation Research]
Broustas, C. G. & Lieberman, H. B. RAD9 enhances radioresistance of human prostate cancer cells through regulation of ITGB1 protein levels. Prostate 74, 1359-1370, doi:10.1002/pros.22842 (2014). [The Prostate]
Lee, Y. H., Sun, Y. & Glickman, R. D. Ursolic Acid-Regulated Energy Metabolism-Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage? Proteomes 2, 399-425, doi:10.3390/proteomes2030399 (2014). [Proteomes]
Zhang, B., Davidson, M. M. & Hei, T. K. Mitochondria regulate DNA damage and genomic instability induced by high LET radiation. Life Sci Space Res (Amst) 1, 80-88, doi:10.1016/j.lssr.2014.02.006 (2014). [Life Sciences in Space Research]
Luo, X., Suzuki, M., Ghandhi, S. A., Amundson, S. A. & Boothman, D. A. ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS One 9, e99983, doi:10.1371/journal.pone.0099983 (2014). [PLOS]
Brown, J. M., Carlson, D. J. & Brenner, D. J. Dose escalation, not "new biology," can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer. In reply to Rao et al. Int J Radiat Oncol Biol Phys 89, 693-694, doi:10.1016/j.ijrobp.2014.03.014 (2014). [International Journal of Radiation Oncology*Biology*Physics]
Ciaffardini, F., Nicolai, S., Caputo, M., Canu, G., Paccosi, E., Costantino, M., Frontini, M., Balajee, A. S. & Proietti-De-Santis, L. The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis. Cell Death Dis 5, e1268, doi:10.1038/cddis.2014.228 (2014). [Cell Death and Disease]
Zhao, Y., de Toledo, S. M., Hu, G., Hei, T. K. & Azzam, E. I. Connexins and cyclooxygenase-2 crosstalk in the expression of radiation-induced bystander effects. Br J Cancer 111, 125-131, doi:10.1038/bjc.2014.276 (2014). [British Journal of Cancer]
Shuryak, I., Lubin, J. H. & Brenner, D. J. Potential for adult-based epidemiological studies to characterize overall cancer risks associated with a lifetime of CT scans. Radiat Res 181, 584-591, doi:10.1667/RR13622.1 (2014). [Radiation Research]
Trattner, S., Cheng, B., Pieniazek, R. L., Hoffmann, U., Douglas, P. S. & Einstein, A. J. Sample size requirements for estimating effective dose from computed tomography using solid-state metal-oxide-semiconductor field-effect transistor dosimetry. Med Phys 41, 042102, doi:10.1118/1.4868693 (2014). [Medical Physics]
Brenner, D. J. Radiation doses from radiological imaging do not increase the risk of cancer: author reply. Br J Radiol 87, 20140133, doi:10.1259/bjr.20140133 (2014). [British Institute of Radiology]
Martinerie, L., Manterola, M., Chung, S. S., Panigrahi, S. K., Weisbach, M., Vasileva, A., Geng, Y., Sicinski, P. & Wolgemuth, D. J. Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. PLoS Genet 10, e1004165, doi:10.1371/journal.pgen.1004165 (2014). [PLOS]
Calaf, G. M., Balajee, A. S., Montalvo-Villagra, M. T., Leon, M., Daniela, N. M., Alvarez, R. G., Roy, D., Narayan, G. & Abarca-Quinones, J. Vimentin and Notch as biomarkers for breast cancer progression. Oncol Lett 7, 721-727, doi:10.3892/ol.2014.1781 (2014). [Oncology Letters]
Meador, J. A., Baldwin, A. J., Pakulski, J. D., Jeffrey, W. H., Mitchell, D. L. & Douki, T. The significance of the Dewar valence photoisomer as a UV radiation-induced DNA photoproduct in marine microbial communities. Environ Microbiol 16, 1808-1820, doi:10.1111/1462-2920.12414 (2014). [Environmental Microbiology]
Lyulko, O. V., Garty, G., Randers-Pehrson, G., Turner, H. C., Szolc, B. & Brenner, D. J. Fast image analysis for the micronucleus assay in a fully automated high-throughput biodosimetry system. Radiat Res 181, 146-161, doi:10.1667/RR13441.1 (2014). [Radiation Research]
Turner, H. C., Sharma, P., Perrier, J. R., Bertucci, A., Smilenov, L., Johnson, G., Taveras, M., Brenner, D. J. & Garty, G. The RABiT: high-throughput technology for assessing global DSB repair. Radiat Environ Biophys 53, 265-272, doi:10.1007/s00411-014-0514-0 (2014). [Radiation and Environmental Physics]
Shuryak, I., Bryan, R. A., Nosanchuk, J. D. & Dadachova, E. Mathematical modeling predicts enhanced growth of X-ray irradiated pigmented fungi. PLoS One 9, e85561, doi:10.1371/journal.pone.0085561 (2014). [PLOS]
Brown, J. M., Carlson, D. J. & Brenner, D. J. The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved? Int J Radiat Oncol Biol Phys 88, 254-262, doi:10.1016/j.ijrobp.2013.07.022 (2014). [International Journal of Radiation Oncology*Biology*Physics]
Broustas, C. G. & Lieberman, H. B. DNA damage response genes and the development of cancer metastasis. Radiat Res 181, 111-130, doi:10.1667/RR13515.1 (2014). [Radiation Research]
Brenner, D. J., Vazquez, M., Buonanno, M., Amundson, S. A., Bigelow, A. W., Garty, G., Harken, A. D., Hei, T. K., Marino, S. A., Ponnaiya, B., Randers-Pehrson, G. & Xu, Y. Integrated interdisciplinary training in the radiological sciences. Br J Radiol 87, 20130779, doi:10.1259/bjr.20130779 (2014). [British Institute of Radiology]
Brenner, D. J. What we know and what we don't know about cancer risks associated with radiation doses from radiological imaging. Br J Radiol 87, 20130629, doi:10.1259/bjr.20130629 (2014). [British Journal of Radiology]
Brenner, D. J., Shuryak, I., Jozsef, G., Dewyngaert, K. J. & Formenti, S. C. Risk and risk reduction of major coronary events associated with contemporary breast radiotherapy. JAMA Intern Med 174, 158-160, doi:10.1001/jamainternmed.2013.11790 (2014). [JAMA Internal Medicine]
Ivanov, V. N. & Hei, T. K. A role for TRAIL/TRAIL-R2 in radiation-induced apoptosis and radiation-induced bystander response of human neural stem cells. Apoptosis 19, 399-413, doi:10.1007/s10495-013-0925-4 (2014). [Apoptosis]
Zepeda, A. B., Figueroa, C. A., Calaf, G. M. & Farias, J. G. Male reproductive system and antioxidants in oxidative stress induced by hypobaric hypoxia. Andrologia 46, 1-8, doi:10.1111/and.12039 (2014). [Andrologia]

2013 Publications

Grad, M., Young, E. F., Smilenov, L., Brenner, D. J. & Attinger, D. A simple add-on microfluidic appliance for accurately sorting small populations of cells with high fidelity. J Micromech Microeng 23, doi:10.1088/0960-1317/23/11/117003 (2013). [Journal of Micromechanics and Microengineering]
Shuryak, I., Smilenov, L. B., Kleiman, N. J. & Brenner, D. J. Potential reduction of contralateral second breast-cancer risks by prophylactic mammary irradiation: validation in a breast-cancer-prone mouse model. PLoS One 8, e85795, doi:10.1371/journal.pone.0085795 (2013). [PLOS]
Paul, S., Smilenov, L. B. & Amundson, S. A. Widespread decreased expression of immune function genes in human peripheral blood following radiation exposure. Radiat Res 180, 575-583, doi:10.1667/RR13343.1 (2013). [Radiation Research]
Grabham, P. & Sharma, P. The effects of radiation on angiogenesis. Vasc Cell 5, 19, doi:10.1186/2045-824X-5-19 (2013). [Vascular Cell]
Buonanno, M., Randers-Pehrson, G., Bigelow, A. W., Trivedi, S., Lowy, F. D., Spotnitz, H. M., Hammer, S. M. & Brenner, D. J. 207-nm UV light - a promising tool for safe low-cost reduction of surgical site infections. I: in vitro studies. PLoS One 8, e76968, doi:10.1371/journal.pone.0076968 (2013). [PLOS]
Grabham, P., Sharma, P., Bigelow, A. & Geard, C. Two distinct types of the inhibition of vasculogenesis by different species of charged particles. Vasc Cell 5, 16, doi:10.1186/2045-824X-5-16 (2013). [Vascular Cell]
Lyndaker, A. M., Vasileva, A., Wolgemuth, D. J., Weiss, R. S. & Lieberman, H. B. Clamping down on mammalian meiosis. Cell Cycle 12, 3135-3145, doi:10.4161/cc.26061 (2013). [Cell Cycle]
Ponnaiya, B., Amundson, S. A., Ghandhi, S. A., Smilenov, L. B., Geard, C. R., Buonanno, M. & Brenner, D. J. Single-cell responses to ionizing radiation. Radiat Environ Biophys 52, 523-530, doi:10.1007/s00411-013-0488-3 (2013). [Radiation and Environmental Biophysics]
Vasileva, A., Hopkins, K. M., Wang, X., Weisbach, M. M., Friedman, R. A., Wolgemuth, D. J. & Lieberman, H. B. The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse. J Cell Sci 126, 3927-3938, doi:10.1242/jcs.126763 (2013). [Journal of Cell Science]
Bigelow, A. W., Ponnaiya, B., Targoff, K. L. & Brenner, D. J. UV microspot irradiator at Columbia University. Radiat Environ Biophys 52, 411-417, doi:10.1007/s00411-013-0474-9 (2013). [Radiation and Environmental Biophysics]
Ivanov, V. N. & Hei, T. K. Induction of apoptotic death and retardation of neuronal differentiation of human neural stem cells by sodium arsenite treatment. Exp Cell Res 319, 875-887, doi:10.1016/j.yexcr.2012.11.019 (2013). [Experimental Cell Research]
Sharma, P., Templin, T. & Grabham, P. Short term effects of gamma radiation on endothelial barrier function: uncoupling of PECAM-1. Microvasc Res 86, 11-20, doi:10.1016/j.mvr.2012.11.007 (2013). [Microvascular Research]
Ivanov, V. N., Wen, G. & Hei, T. K. Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. Apoptosis 18, 188-200, doi:10.1007/s10495-012-0779-1 (2013). [Apoptosis]
Zhang, S., Wen, G., Huang, S. X., Wang, J., Tong, J. & Hei, T. K. Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by alpha-particles. Int J Cancer 132, 19-28, doi:10.1002/ijc.27656 (2013). [International Journal of Cancer]

2012 Publications

Hall, E. J. & Brenner, D. J. Cancer risks from diagnostic radiology: the impact of new epidemiological data. Br J Radiol 85, e1316-1317, doi:10.1259/bjr/13739950 (2012). [The British Journal of Radiology]
Brenner, D. J. Minimising medically unwarranted computed tomography scans. Ann ICRP 41, 161-169, doi:10.1016/j.icrp.2012.06.004 (2012). [Annals of the ICRP]
Brenner, D. J. We can do better than effective dose for estimating or comparing low-dose radiation risks. Ann ICRP 41, 124-128, doi:10.1016/j.icrp.2012.07.001 (2012). [Annals of the ICRP]
Broustas, C. G., Zhu, A. & Lieberman, H. B. Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance. J Biol Chem 287, 41324-41333, doi:10.1074/jbc.M112.402784 (2012). [Journal of Biological Chemistry]
Brenner, D. J. Radiation and chest CT scans: are there problems? What should we do? Chest 142, 549-550, doi:10.1378/chest.12-0490 (2012). [Chest]
Brenner, D. J. Exploring two two-edged swords. Radiat Res 178, 7-16 (2012). [Radiation Research]
Shuryak, I. & Brenner, D. J. Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death. Radiat Res 178, 17-24 (2012). [Radiation Research]
Young, E. F., Smilenov, L. B., Lieberman, H. B. & Hall, E. J. Combined haploinsufficiency and genetic control of the G2/M checkpoint in irradiated cells. Radiat Res 177, 743-750 (2012). [Radiation Research]
Templin, T., Young, E. F. & Smilenov, L. B. Proton radiation-induced miRNA signatures in mouse blood: characterization and comparison with 56Fe-ion and gamma radiation. Int J Radiat Biol 88, 531-539, doi:10.3109/09553002.2012.690549 (2012). [International Journal of Radiation Biology]
Grabham, P., Bigelow, A. & Geard, C. DNA damage foci formation and decline in two-dimensional monolayers and in three-dimensional human vessel models: differential effects according to radiation quality. Int J Radiat Biol 88, 493-500, doi:10.3109/09553002.2012.679382 (2012). [International Journal of Radiation Biology]
Hu, B., Grabham, P., Nie, J., Balajee, A. S., Zhou, H., Hei, T. K. & Geard, C. R. Intrachromosomal changes and genomic instability in site-specific microbeam-irradiated and bystander human-hamster hybrid cells. Radiat Res 177, 25-34 (2012). [Radiation Research]
Broustas, C. G. & Lieberman, H. B. Contributions of Rad9 to tumorigenesis. J Cell Biochem 113, 742-751, doi:10.1002/jcb.23424 (2012). [Journal of Cellular Biochemistry]

2011 Publications

Shuryak, I., Brenner, D. J. & Ullrich, R. L. Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA. PLoS One 6, e28559, doi:10.1371/journal.pone.0028559 (2011). [PLOS]
Ivanov, V. N. & Hei, T. K. Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy. Apoptosis 16, 1268-1284, doi:10.1007/s10495-011-0649-2 (2011). [Apoptosis]
Young, E. F. & Smilenov, L. B. Impedance-based surveillance of transient permeability changes in coronary endothelial monolayers after exposure to ionizing radiation. Radiat Res 176, 415-424 (2011). [Radiation Research]
Harken, A. D., Randers-Pehrson, G., Johnson, G. W. & Brenner, D. J. The Columbia University proton-induced soft x-ray microbeam. Nucl Instrum Methods Phys Res B 269, 1992-1996, doi:10.1016/j.nimb.2011.05.033 (2011). [Nuclear Instruments and Methods]
Paul, S. & Amundson, S. A. Gene expression signatures of radiation exposure in peripheral white blood cells of smokers and non-smokers. Int J Radiat Biol 87, 791-801, doi:10.3109/09553002.2011.568574 (2011). [International Journal of Radiation Biology]
Brenner, D. J., Shuryak, I. & Einstein, A. J. Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging. Radiology 261, 193-198, doi:10.1148/radiol.11102452 (2011). [Radiology]
Ponnaiya, B., Suzuki, M., Tsuruoka, C., Uchihori, Y., Wei, Y. & Hei, T. K. Detection of chromosomal instability in bystander cells after Si490-ion irradiation. Radiat Res 176, 280-290 (2011). [Radiation Research]
Wen, G., Hong, M., Li, B., Liao, W., Cheng, S. K., Hu, B., Calaf, G. M., Lu, P., Partridge, M. A., Tong, J. & Hei, T. K. Transforming growth factor-beta-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway. Int J Oncol 39, 1001-1009, doi:10.3892/ijo.2011.1097 (2011). [International Journal of Oncology]
Wen, G., Partridge, M. A., Li, B., Hong, M., Liao, W., Cheng, S. K., Zhao, Y., Calaf, G. M., Liu, T., Zhou, J., Zhang, Z. & Hei, T. K. TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells. Cancer Lett 308, 23-32, doi:10.1016/j.canlet.2011.04.010 (2011). [Cancer Letters]
Meador, J. A., Ghandhi, S. A. & Amundson, S. A. p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiat Res 175, 689-699 (2011). [Radiation Research]
Mezentsev, A. & Amundson, S. A. Global gene expression responses to low- or high-dose radiation in a human three-dimensional tissue model. Radiat Res 175, 677-688, doi:10.1667/RR2483.1 (2011). [Radiation Research]
Lieberman, H. B. Ernest A. McCulloch. Radiat Res 175, 532-533, doi:10.1667/0033-7587-175.4.532 (2011). [Radiation Research]
Marino, S. A., Johnson, G. W., Schiff, P. B. & Brenner, D. J. Modification of shirt buttons for retrospective radiation dosimetry after a radiological event. Health Phys 100, 542-547, doi:10.1097/HP.0b013e31820153d4 (2011). [Health Physics]
Ivanov, V. N., Ghandhi, S. A., Zhou, H., Huang, S. X., Chai, Y., Amundson, S. A. & Hei, T. K. Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: a role for NF-kappaB-STAT3-directed gene expression. Exp Cell Res 317, 1548-1566, doi:10.1016/j.yexcr.2011.03.012 (2011). [Experimental Cell Research]
Brenner, D. J. Are x-ray backscatter scanners safe for airport passenger screening? For most individuals, probably yes, but a billion scans per year raises long-term public health concerns. Radiology 259, 6-10, doi:10.1148/radiol.11102347 (2011). [Radiology]
Templin, T., Paul, S., Amundson, S. A., Young, E. F., Barker, C. A., Wolden, S. L. & Smilenov, L. B. Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys 80, 549-557, doi:10.1016/j.ijrobp.2010.12.061 (2011). [International Journal of Radiation Oncology*Biology*Physics]
Paul, S., Barker, C. A., Turner, H. C., McLane, A., Wolden, S. L. & Amundson, S. A. Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures. Radiat Res 175, 257-265, doi:10.1667/RR2420.1 (2011). [Radiation Research]
Turner, H. C., Brenner, D. J., Chen, Y., Bertucci, A., Zhang, J., Wang, H., Lyulko, O. V., Xu, Y., Shuryak, I., Schaefer, J., Simaan, N., Randers-Pehrson, G., Yao, Y. L., Amundson, S. A. & Garty, G. Adapting the gamma-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects. Radiat Res 175, 282-290, doi:10.1667/RR2125.1 (2011). [Radiation Research]
Lieberman, H. B., Bernstock, J. D., Broustas, C. G., Hopkins, K. M., Leloup, C. & Zhu, A. The role of RAD9 in tumorigenesis. J Mol Cell Biol 3, 39-43, doi:10.1093/jmcb/mjq039 (2011). [Journal of Molecular Cell Biology]
Templin, T., Amundson, S. A., Brenner, D. J. & Smilenov, L. B. Whole mouse blood microRNA as biomarkers for exposure to gamma-rays and (56)Fe ion. Int J Radiat Biol 87, 653-662, doi:10.3109/09553002.2010.549537 (2011). [International Journal of Radiation Biology]
Ivanov, V. N., Partridge, M. A., Huang, S. X. & Hei, T. K. Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis. J Cell Biochem 112, 463-475, doi:10.1002/jcb.22934 (2011). [Journal of Cellular Biochemistry]
Ghandhi, S. A., Sinha, A., Markatou, M. & Amundson, S. A. Time-series clustering of gene expression in irradiated and bystander fibroblasts: an application of FBPA clustering. BMC Genomics 12, 2, doi:10.1186/1471-2164-12-2 (2011). [BMC Genomics]
Grabham, P., Hu, B., Sharma, P. & Geard, C. Effects of ionizing radiation on three-dimensional human vessel models: differential effects according to radiation quality and cellular development. Radiat Res 175, 21-28, doi:10.1667/RR2289.1 (2011). [Radiation Research]
Hei, T. K., Zhou, H., Chai, Y., Ponnaiya, B. & Ivanov, V. N. Radiation induced non-targeted response: mechanism and potential clinical implications. Curr Mol Pharmacol 4, 96-105 (2011). [Current Molecular Pharmacology]
Shuryak, I., Sachs, R. K. & Brenner, D. J. A new view of radiation-induced cancer. Radiat Prot Dosimetry 143, 358-364, doi:10.1093/rpd/ncq389 (2011). [Radiation Protection Dosimetry]

2010 Publications

Su, Y., Meador, J. A., Calaf, G. M., Proietti De-Santis, L., Zhao, Y., Bohr, V. A. & Balajee, A. S. Human RecQL4 helicase plays critical roles in prostate carcinogenesis. Cancer Res 70, 9207-9217, doi:10.1158/0008-5472.CAN-10-1743 (2010). [Cancer Research]
Shuryak, I., Sachs, R. K. & Brenner, D. J. Cancer risks after radiation exposure in middle age. J Natl Cancer Inst 102, 1628-1636, doi:10.1093/jnci/djq346 (2010). [Journal of the National Cancer Institute]
Hong, M., Xu, A., Zhou, H., Wu, L., Randers-Pehrson, G., Santella, R. M., Yu, Z. & Hei, T. K. Mechanism of genotoxicity induced by targeted cytoplasmic irradiation. Br J Cancer 103, 1263-1268, doi:10.1038/sj.bjc.6605888 (2010). [British Journal of Cancer]
Leloup, C., Hopkins, K. M., Wang, X., Zhu, A., Wolgemuth, D. J. & Lieberman, H. B. Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage. Dev Dyn 239, 2837-2850, doi:10.1002/dvdy.22415 (2010). [Developmental Dynamics]
Zhou, G., Smilenov, L. B., Lieberman, H. B., Ludwig, T. & Hall, E. J. Radiosensitivity to high energy iron ions is influenced by heterozygosity for ATM, RAD9 and BRCA1. Adv Space Res 46, 681-686, doi:10.1016/j.asr.2010.02.026 (2010). [Advances in Space Research]
Brenner, D. J. Slowing the increase in the population dose resulting from CT scans. Radiat Res 174, 809-815, doi:10.1667/RR1859.1 (2010). [Radiation Research]
Shuryak, I., Ullrich, R. L., Sachs, R. K. & Brenner, D. J. The balance between initiation and promotion in radiation-induced murine carcinogenesis. Radiat Res 174, 357-366, doi:10.1667/RR2143.1 (2010). [Radiation Research]
Bigelow, A. W., Randers-Pehrson, G., Garty, G., Geard, C. R., Xu, Y., Harken, A. D., Johnson, G. W. & Brenner, D. J. Ion, X-ray, UV and Neutron Microbeam Systems for Cell Irradiation. AIP Conf Proc 1336, 351-355, doi:10.1063/1.3586118 (2010). [AIP Conference Proceedings]
Ghandhi, S. A., Ming, L., Ivanov, V. N., Hei, T. K. & Amundson, S. A. Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts. BMC Med Genomics 3, 31, doi:10.1186/1755-8794-3-31 (2010). [BMC Medical Genomics]
Brenner, D. J. & Hricak, H. Radiation exposure from medical imaging: time to regulate? JAMA 304, 208-209, doi:10.1001/jama.2010.973 (2010). [JAMA]
Shuryak, I. & Brenner, D. J. Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans. Radiat Environ Biophys 49, 693-703, doi:10.1007/s00411-010-0305-1 (2010). [Radiation and Environmental Biophysics]
Brenner, D. J. Should we be concerned about the rapid increase in CT usage? Rev Environ Health 25, 63-68 (2010). [Reviews on Environmental Health]
Karasic, T. B., Hei, T. K. & Ivanov, V. N. Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma. Exp Cell Res 316, 1994-2007, doi:10.1016/j.yexcr.2010.04.014 (2010). [Experimental Cell Research]
Partridge, M. A., Chai, Y., Zhou, H. & Hei, T. K. High-throughput antibody-based assays to identify and quantify radiation-responsive protein biomarkers. Int J Radiat Biol 86, 321-328, doi:10.3109/09553000903564034 (2010). [International Journal of Radiation Biology]
Ivanov, V. N., Zhou, H., Ghandhi, S. A., Karasic, T. B., Yaghoubian, B., Amundson, S. A. & Hei, T. K. Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission. Cell Signal 22, 1076-1087, doi:10.1016/j.cellsig.2010.02.010 (2010). [Cellular Signalling]
Lyulko, O. V., Randers-Pehrson, G. & Brenner, D. J. Immersion Mirau interferometry for label-free live cell imaging in an epi-illumination geometry. Proc SPIE Int Soc Opt Eng 7568, doi:10.1117/12.855651 (2010). [The International Society for Optics and Photonics]
Einstein, A. J., Elliston, C. D., Arai, A. E., Chen, M. Y., Mather, R., Pearson, G. D., Delapaz, R. L., Nickoloff, E., Dutta, A. & Brenner, D. J. Radiation dose from single-heartbeat coronary CT angiography performed with a 320-detector row volume scanner. Radiology 254, 698-706, doi:10.1148/radiol.09090779 (2010). [Radiology]
Garty, G., Chen, Y., Salerno, A., Turner, H., Zhang, J., Lyulko, O., Bertucci, A., Xu, Y., Wang, H., Simaan, N., Randers-Pehrson, G., Yao, Y. L., Amundson, S. A. & Brenner, D. J. The RABIT: a rapid automated biodosimetry tool for radiological triage. Health Phys 98, 209-217, doi:10.1097/HP.0b013e3181ab3cb6 (2010). [Health Physics]
Meador, J. A., Su, Y., Ravanat, J. L. & Balajee, A. S. DNA-dependent protein kinase (DNA-PK)-deficient human glioblastoma cells are preferentially sensitized by Zebularine. Carcinogenesis 31, 184-191, doi:10.1093/carcin/bgp284 (2010). [Carcinogenesis]

2000-2009 Publications

Randers-Pehrson, G., Johnson, G. W., Marino, S. A., Xu, Y., Dymnikov, A. D. & Brenner, D. J. The Columbia University Sub-micron Charged Particle Beam. Nucl Instrum Methods Phys Res A 609, 294-299, doi:10.1016/j.nima.2009.08.041 (2009).
Brenner, D. J. Extrapolating radiation-induced cancer risks from low doses to very low doses. Health Phys 97, 505-509, doi:10.1097/HP.0b013e3181ad7f04 (2009).
Brenner, D. J., Elliston, C. D., Hall, E. J. & Paganetti, H. Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator. Phys Med Biol 54, 6065-6078, doi:10.1088/0031-9155/54/20/003 (2009).
Shuryak, I. & Brenner, D. J. A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. J Theor Biol 261, 305-317, doi:10.1016/j.jtbi.2009.08.003 (2009).
Hall, E. J., Metting, N., Puskin, J. & Ron, E. Low dose radiation epidemiology: what can it tell us? Radiat Res 172, 134-138, doi:10.1667/RR1777.1 (2009).
Hu, B., Shen, B., Su, Y., Geard, C. R. & Balajee, A. S. Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. Int J Biochem Cell Biol 41, 2413-2421, doi:10.1016/j.biocel.2009.06.012 (2009).
Shuryak, I., Hahnfeldt, P., Hlatky, L., Sachs, R. K. & Brenner, D. J. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat Environ Biophys 48, 263-274, doi:10.1007/s00411-009-0230-3 (2009).
Shuryak, I., Hahnfeldt, P., Hlatky, L., Sachs, R. K. & Brenner, D. J. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys 48, 275-286, doi:10.1007/s00411-009-0231-2 (2009).
Bertucci, A., Pocock, R. D., Randers-Pehrson, G. & Brenner, D. J. Microbeam irradiation of the C. elegans nematode. J Radiat Res 50 Suppl A, A49-54 (2009).
Bigelow, A., Garty, G., Funayama, T., Randers-Pehrson, G., Brenner, D. & Geard, C. Expanding the question-answering potential of single-cell microbeams at RARAF, USA. J Radiat Res 50 Suppl A, A21-28 (2009).
Hei, T. K., Ballas, L. K., Brenner, D. J. & Geard, C. R. Advances in radiobiological studies using a microbeam. J Radiat Res 50 Suppl A, A7-A12 (2009).
Zhou, H., Hong, M., Chai, Y. & Hei, T. K. Consequences of cytoplasmic irradiation: studies from microbeam. J Radiat Res 50 Suppl A, A59-65 (2009).
Ivanov, V. N., Zhou, H., Partridge, M. A. & Hei, T. K. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer Res 69, 3510-3519, doi:10.1158/0008-5472.CAN-08-3883 (2009).
Partridge, M. A., Huang, S. X., Kibriya, M. G., Ahsan, H., Davidson, M. M. & Hei, T. K. Environmental mutagens induced transversions but not transitions in regulatory region of mitochondrial DNA. J Toxicol Environ Health A 72, 301-304, doi:10.1080/15287390802526381 (2009).
Xu, A., Chai, Y., Nohmi, T. & Hei, T. K. Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells. Part Fibre Toxicol 6, 3, doi:10.1186/1743-8977-6-3 (2009).
Bigelow, A. W., Geard, C. R., Randers-Pehrson, G. & Brenner, D. J. Microbeam-integrated multiphoton imaging system. Rev Sci Instrum 79, 123707, doi:10.1063/1.3043439 (2008).
Zhang, Y., Wen, G., Shao, G., Wang, C., Lin, C., Fang, H., Balajee, A. S., Bhagat, G., Hei, T. K. & Zhao, Y. TGFBI deficiency predisposes mice to spontaneous tumor development. Cancer Res 69, 37-44, doi:10.1158/0008-5472.CAN-08-1648 (2009).
Ghandhi, S. A., Yaghoubian, B. & Amundson, S. A. Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: synchronous and differential responses. BMC Med Genomics 1, 63, doi:10.1186/1755-8794-1-63 (2008).
Wen, G., Partridge, M. A., Calaf, G. M., Meador, J. A., Hu, B., Echiburu-Chau, C., Hong, M. & Hei, T. K. Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment. Sci Total Environ 407, 1174-1181, doi:10.1016/j.scitotenv.2008.09.045 (2009).
Brenner, D. J. Should computed tomography be the modality of choice for imaging Crohn's disease in children? The radiation risk perspective. Gut 57, 1489-1490, doi:10.1136/gut.2008.156265 (2008).
Shah, J. N., Shao, G., Hei, T. K. & Zhao, Y. Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR. BMC Cancer 8, 284, doi:10.1186/1471-2407-8-284 (2008).
Brenner, D. J. The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. Semin Radiat Oncol 18, 234-239, doi:10.1016/j.semradonc.2008.04.004 (2008).
Hei, T. K., Zhou, H., Ivanov, V. N., Hong, M., Lieberman, H. B., Brenner, D. J., Amundson, S. A. & Geard, C. R. Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol 60, 943-950, doi:10.1211/jpp.60.8.0001 (2008).
Paul, S. & Amundson, S. A. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys 71, 1236-1244, doi:10.1016/j.ijrobp.2008.03.043 (2008).
Meador, J. A., Zhao, M., Su, Y., Narayan, G., Geard, C. R. & Balajee, A. S. Histone H2AX is a critical factor for cellular protection against DNA alkylating agents. Oncogene 27, 5662-5671, doi:10.1038/onc.2008.187 (2008).
Amundson, S. A. Functional Genomics and a New Era in Radiation Biology and Oncology. Bioscience 58, 491-500, doi:10.1641/B580606 (2008).
Sakamoto-Hojo, E. T. & Balajee, A. S. Targeting poly (ADP) ribose polymerase I (PARP-1) and PARP-1 interacting proteins for cancer treatment. Anticancer Agents Med Chem 8, 402-416 (2008).
Johnson, G. E., Ivanov, V. N. & Hei, T. K. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. Apoptosis 13, 790-802, doi:10.1007/s10495-008-0212-y (2008).
Brenner, D. J. Effective dose: a flawed concept that could and should be replaced. Br J Radiol 81, 521-523, doi:10.1259/bjr/22942198 (2008).
Hall, E. J. & Brenner, D. J. Cancer risks from diagnostic radiology. Br J Radiol 81, 362-378, doi:10.1259/bjr/01948454 (2008).
Calaf, G. M., Echiburu-Chau, C., Zhao, Y. L. & Hei, T. K. BigH3 protein expression as a marker for breast cancer. Int J Mol Med 21, 561-568 (2008).
Zhou, H., Ivanov, V. N., Lien, Y. C., Davidson, M. & Hei, T. K. Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res 68, 2233-2240, doi:10.1158/0008-5472.CAN-07-5278 (2008).
Zhu, A., Zhang, C. X. & Lieberman, H. B. Rad9 has a functional role in human prostate carcinogenesis. Cancer Res 68, 1267-1274, doi:10.1158/0008-5472.CAN-07-2304 (2008).
Lieberman, H. B. DNA damage repair and response proteins as targets for cancer therapy. Curr Med Chem 15, 360-367 (2008).
Ivanov, V. N., Partridge, M. A., Johnson, G. E., Huang, S. X., Zhou, H. & Hei, T. K. Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res 314, 1163-1176, doi:10.1016/j.yexcr.2007.12.012 (2008).
Amundson, S. A., Do, K. T., Vinikoor, L. C., Lee, R. A., Koch-Paiz, C. A., Ahn, J., Reimers, M., Chen, Y., Scudiero, D. A., Weinstein, J. N., Trent, J. M., Bittner, M. L., Meltzer, P. S. & Fornace, A. J., Jr. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res 68, 415-424, doi:10.1158/0008-5472.CAN-07-2120 (2008).
Brenner, D. J. & Hall, E. J. Secondary neutrons in clinical proton radiotherapy: a charged issue. Radiother Oncol 86, 165-170, doi:10.1016/j.radonc.2007.12.003 (2008).
Shuryak, I., Sachs, R. K. & Brenner, D. J. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat Res 168, 741-749, doi:10.1667/RR1117.1 (2007).
Brenner, D. J. & Hall, E. J. Computed tomography--an increasing source of radiation exposure. N Engl J Med 357, 2277-2284, doi:10.1056/NEJMra072149 (2007).
Wen, G., Calaf, G. M., Partridge, M. A., Echiburu-Chau, C., Zhao, Y., Huang, S., Chai, Y., Li, B., Hu, B. & Hei, T. K. Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med 14, 2-10, doi:10.2119/2007-00090.Wen (2008).
Amundson, S. A. Functional genomics in radiation biology: a gateway to cellular systems-level studies. Radiat Environ Biophys 47, 25-31, doi:10.1007/s00411-007-0140-1 (2008).
Kleiman, N. J., David, J., Elliston, C. D., Hopkins, K. M., Smilenov, L. B., Brenner, D. J., Worgul, B. V., Hall, E. J. & Lieberman, H. B. Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice. Radiat Res 168, 567-573, doi:10.1667/rr1122.1 (2007).
Brenner, D. J., Shuryak, I., Russo, S. & Sachs, R. K. Reducing second breast cancers: a potential role for prophylactic mammary irradiation. J Clin Oncol 25, 4868-4872, doi:10.1200/JCO.2007.11.0379 (2007).
Baskar, R., Balajee, A. S., Geard, C. R. & Hande, M. P. Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells. Int J Biochem Cell Biol 40, 125-134, doi:10.1016/j.biocel.2007.07.002 (2008).
Hall, E. J. The impact of protons on the incidence of second malignancies in radiotherapy. Technol Cancer Res Treat 6, 31-34, doi:10.1177/15330346070060S405 (2007).
Partridge, M. A., Davidson, M. M. & Hei, T. K. The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA. DNA Seq 18, 341-346, doi:10.1080/10425170601101287 (2007).
Wang, J., Yin, D. P., Liu, Y. X., Baer, R. & Yin, Y. Dual specificity phosphatase 1/CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress. Cancer Res 67, 6737-6744, doi:10.1158/0008-5472.CAN-06-4402 (2007).
Baskar, R., Balajee, A. S. & Geard, C. R. Effects of low and high LET radiations on bystander human lung fibroblast cell survival. Int J Radiat Biol 83, 551-559, doi:10.1080/09553000701384499 (2007).
Persaud, R., Zhou, H., Hei, T. K. & Hall, E. J. Demonstration of a radiation-induced bystander effect for low dose low LET beta-particles. Radiat Environ Biophys 46, 395-400, doi:10.1007/s00411-007-0116-1 (2007).
Ivanov, V. N., Zhou, H. & Hei, T. K. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res 67, 5397-5407, doi:10.1158/0008-5472.CAN-07-0551 (2007).
Partridge, M. A., Huang, S. X., Hernandez-Rosa, E., Davidson, M. M. & Hei, T. K. Arsenic induced mitochondrial DNA damage and altered mitochondrial oxidative function: implications for genotoxic mechanisms in mammalian cells. Cancer Res 67, 5239-5247, doi:10.1158/0008-5472.CAN-07-0074 (2007).
Wu, J., Jin, Y. J., Calaf, G. M., Huang, W. L. & Yin, Y. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene 26, 6526-6535, doi:10.1038/sj.onc.1210484 (2007).
Xu, A., Huang, X., Lien, Y. C., Bao, L., Yu, Z. & Hei, T. K. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chem Res Toxicol 20, 724-733, doi:10.1021/tx600364d (2007).
Ponnaiya, B., Jenkins-Baker, G., Randers-Pherson, G. & Geard, C. R. Quantifying a bystander response following microbeam irradiation using single-cell RT-PCR analyses. Exp Hematol 35, 64-68, doi:10.1016/j.exphem.2007.01.013 (2007).
Xu, A., Smilenov, L. B., He, P., Masumura, K., Nohmi, T., Yu, Z. & Hei, T. K. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ Health Perspect 115, 87-92, doi:10.1289/ehp.9425 (2007).
Shuryak, I., Sachs, R. K., Hlatky, L., Little, M. P., Hahnfeldt, P. & Brenner, D. J. Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst 98, 1794-1806, doi:10.1093/jnci/djj497 (2006).
Smilenov, L. B., Hall, E. J., Bonner, W. M. & Sedelnikova, O. A. A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts. Radiat Prot Dosimetry 122, 256-259, doi:10.1093/rpd/ncl461 (2006).
Calaf, G. M., Parra, E. & Garrido, F. Cell proliferation and tumor formation induced by eserine, an acetylcholinesterase inhibitor, in rat mammary gland. Oncol Rep 17, 25-33 (2007).
Ivanov, V. N. & Hei, T. K. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res 312, 4120-4138, doi:10.1016/j.yexcr.2006.09.019 (2006).
Hei, T. K., Xu, A., Huang, S. X. & Zhao, Y. Mechanism of fiber carcinogenesis: from reactive radical species to silencing of the beta igH3 gene. Inhal Toxicol 18, 985-990, doi:10.1080/08958370600835310 (2006).
Hall, E. J., Worgul, B. V., Smilenov, L., Elliston, C. D. & Brenner, D. J. The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterozygous for the ATM gene. Radiat Environ Biophys 45, 99-104, doi:10.1007/s00411-006-0052-5 (2006).
Brenner, D. J. It is time to retire the computed tomography dose index (CTDI) for CT quality assurance and dose optimization. For the proposition. Med Phys 33, 1189-1190, doi:10.1118/1.2173933 (2006).
Hall, E. J. The inaugural Frank Ellis Lecture--latrogenic cancer: the impact of intensity-modulated radiotherapy. Clin Oncol (R Coll Radiol) 18, 277-282 (2006).
Shao, G., Berenguer, J., Borczuk, A. C., Powell, C. A., Hei, T. K. & Zhao, Y. Epigenetic inactivation of Betaig-h3 gene in human cancer cells. Cancer Res 66, 4566-4573, doi:10.1158/0008-5472.CAN-05-2130 (2006).
Hei, T. K. Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect. Mol Carcinog 45, 455-460, doi:10.1002/mc.20219 (2006).
Hall, E. J. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 65, 1-7, doi:10.1016/j.ijrobp.2006.01.027 (2006).
Ivanov, V. N. & Hei, T. K. Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Exp Cell Res 312, 1401-1417, doi:10.1016/j.yexcr.2006.01.003 (2006).
Brenner, D. J. & Sachs, R. K. Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach. Radiat Environ Biophys 44, 253-256, doi:10.1007/s00411-006-0029-4 (2006).
Roy, D., Calaf, G. M., Hande, M. P. & Hei, T. K. Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression. Int J Oncol 28, 667-674 (2006).
Calaf, G. M. Susceptibility of human breast epithelial cells in vitro to hormones and drugs. Int J Oncol 28, 285-295 (2006).
Lieberman, H. B. Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity. J Cell Biochem 97, 690-697, doi:10.1002/jcb.20759 (2006).
Zhao, Y., El-Gabry, M. & Hei, T. K. Loss of Betaig-h3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cells. Mol Carcinog 45, 84-92, doi:10.1002/mc.20167 (2006).
Ivanov, V. N., Ronai, Z. & Hei, T. K. Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis. J Biol Chem 281, 1840-1852, doi:10.1074/jbc.M509866200 (2006).
Persaud, R., Zhou, H., Baker, S. E., Hei, T. K. & Hall, E. J. Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res 65, 9876-9882, doi:10.1158/0008-5472.CAN-04-2875 (2005).
Zhou, H., Xu, A., Gillispie, J. A., Waldren, C. A. & Hei, T. K. Quantification of CD59- mutants in human-hamster hybrid (AL) cells by flow cytometry. Mutat Res 594, 113-119, doi:10.1016/j.mrfmmm.2005.08.009 (2006).
Zhu, A., Zhou, H., Leloup, C., Marino, S. A., Geard, C. R., Hei, T. K. & Lieberman, H. B. Differential impact of mouse Rad9 deletion on ionizing radiation-induced bystander effects. Radiat Res 164, 655-661 (2005).
Smilenov, L. B. Tumor development: haploinsufficiency and local network assembly. Cancer Lett 240, 17-28, doi:10.1016/j.canlet.2005.08.015 (2006).
Zhou, H., Ivanov, V. N., Gillespie, J., Geard, C. R., Amundson, S. A., Brenner, D. J., Yu, Z., Lieberman, H. B. & Hei, T. K. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci U S A 102, 14641-14646, doi:10.1073/pnas.0505473102 (2005).
Belyakov, O. V., Mitchell, S. A., Parikh, D., Randers-Pehrson, G., Marino, S. A., Amundson, S. A., Geard, C. R. & Brenner, D. J. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc Natl Acad Sci U S A 102, 14203-14208, doi:10.1073/pnas.0505020102 (2005).
Calaf, G. M., Alvarado, M. E. & Hei, T. K. Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene. Oncol Rep 14, 885-893 (2005).
Calaf, G. M., Roy, D. & Hei, T. K. Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation. Histochem Cell Biol 124, 261-274, doi:10.1007/s00418-005-0033-9 (2005).
Brenner, D. J. & Mossman, K. L. Do radiation doses below 1 cGy increase cancer risks? Radiat Res 163, 692-693 (2005).
Hall, E. J. Multiple gene effects in radiation oncogenesis. Radiat Res 163, 697-698 (2005).
Brenner, D. J. & Georgsson, M. A. Mass screening with CT colonography: should the radiation exposure be of concern? Gastroenterology 129, 328-337 (2005).
Hall, E. J., Brenner, D. J., Worgul, B. & Smilenov, L. Genetic susceptibility to radiation. Adv Space Res 35, 249-253 (2005).
Hande, M. P., Azizova, T. V., Burak, L. E., Khokhryakov, V. F., Geard, C. R. & Brenner, D. J. Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH study. Genes Chromosomes Cancer 44, 1-9, doi:10.1002/gcc.20217 (2005).
Zhou, H., Randers-Pehrson, G., Waldren, C. A. & Hei, T. K. Radiation-induced bystander effect and adaptive response in mammalian cells. Adv Space Res 34, 1368-1372 (2004).
Calaf, G. M., Emenaker, N. J. & Hei, T. K. Effect of retinol on radiation- and estrogen-induced neoplastic transformation of human breast epithelial cells. Oncol Rep 13, 1017-1027 (2005).
Liu, S. X., Davidson, M. M., Tang, X., Walker, W. F., Athar, M., Ivanov, V. & Hei, T. K. Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells. Cancer Res 65, 3236-3242, doi:10.1158/0008-5472.CAN-05-0424 (2005).
Smilenov, L. B., Lieberman, H. B., Mitchell, S. A., Baker, R. A., Hopkins, K. M. & Hall, E. J. Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics. Cancer Res 65, 933-938 (2005).
Hall, E. J. Dose-painting by numbers: a feasible approach? Lancet Oncol 6, 66, doi:10.1016/S1470-2045(05)01718-3 (2005).
Piao, C. Q., Liu, L., Zhao, Y. L., Balajee, A. S., Suzuki, M. & Hei, T. K. Immortalization of human small airway epithelial cells by ectopic expression of telomerase. Carcinogenesis 26, 725-731, doi:10.1093/carcin/bgi016 (2005).
Ivanov, V. N. & Hei, T. K. Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway. Oncogene 24, 616-626, doi:10.1038/sj.onc.1208125 (2005).
Balajee, A. S., Ponnaiya, B., Baskar, R. & Geard, C. R. Induction of replication protein A in bystander cells. Radiat Res 162, 677-686 (2004).
Zhao, Y., Shao, G., Piao, C. Q., Berenguer, J. & Hei, T. K. Down-regulation of Betaig-h3 gene is involved in the tumorigenesis in human bronchial epithelial cells induced by heavy-ion radiation. Radiat Res 162, 655-659 (2004).
Calaf, G. M. & Hei, T. K. Ionizing radiation induces alterations in cellular proliferation and c-myc, c-jun and c-fos protein expression in breast epithelial cells. Int J Oncol 25, 1859-1866 (2004).
Hei, T. K., Persaud, R., Zhou, H. & Suzuki, M. Genotoxicity in the eyes of bystander cells. Mutat Res 568, 111-120, doi:10.1016/j.mrfmmm.2004.07.015 (2004).
Ponnaiya, B., Jenkins-Baker, G., Bigelow, A., Marino, S. & Geard, C. R. Detection of chromosomal instability in alpha-irradiated and bystander human fibroblasts. Mutat Res 568, 41-48, doi:10.1016/j.mrfmmm.2004.06.045 (2004).
Balajee, A. S. & Geard, C. R. Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks. Exp Cell Res 300, 320-334, doi:10.1016/j.yexcr.2004.07.022 (2004).
Ponnaiya, B., Jenkins-Baker, G., Brenner, D. J., Hall, E. J., Randers-Pehrson, G. & Geard, C. R. Biological responses in known bystander cells relative to known microbeam-irradiated cells. Radiat Res 162, 426-432 (2004).
Mitchell, C. R., Azizova, T. V., Hande, M. P., Burak, L. E., Tsakok, J. M., Khokhryakov, V. F., Geard, C. R. & Brenner, D. J. Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiat Res 162, 257-263 (2004).
Mitchell, S. A., Marino, S. A., Brenner, D. J. & Hall, E. J. Bystander effect and adaptive response in C3H 10T(1/2) cells. Int J Radiat Biol 80, 465-472 (2004).
Suzuki, M., Zhou, H., Geard, C. R. & Hei, T. K. Effect of medium on chromatin damage in bystander mammalian cells. Radiat Res 162, 264-269 (2004).
Hei, T. K. & Filipic, M. Role of oxidative damage in the genotoxicity of arsenic. Free Radic Biol Med 37, 574-581, doi:10.1016/j.freeradbiomed.2004.02.003 (2004).
Hopkins, K. M., Auerbach, W., Wang, X. Y., Hande, M. P., Hang, H., Wolgemuth, D. J., Joyner, A. L. & Lieberman, H. B. Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality. Mol Cell Biol 24, 7235-7248, doi:10.1128/MCB.24.16.7235-7248.2004 (2004).
Lieberman, H. B. & Yin, Y. A novel function for human Rad9 protein as a transcriptional activator of gene expression. Cell Cycle 3, 1008-1010 (2004).
Brenner, D. J. & Elliston, C. D. Estimated radiation risks potentially associated with full-body CT screening. Radiology 232, 735-738, doi:10.1148/radiol.2323031095 (2004).
Yin, Y., Zhu, A., Jin, Y. J., Liu, Y. X., Zhang, X., Hopkins, K. M. & Lieberman, H. B. Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21. Proc Natl Acad Sci U S A 101, 8864-8869, doi:10.1073/pnas.0403130101 (2004).
Brenner, D. J. Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. Radiology 231, 440-445, doi:10.1148/radiol.2312030880 (2004).
Mitchell, S. A., Randers-Pehrson, G., Brenner, D. J. & Hall, E. J. The bystander response in C3H 10T1/2 cells: the influence of cell-to-cell contact. Radiat Res 161, 397-401 (2004).
Ivanov, V. N. & Hei, T. K. Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway. J Biol Chem 279, 22747-22758, doi:10.1074/jbc.M314131200 (2004).
Brenner, D. J., Doll, R., Goodhead, D. T., Hall, E. J., Land, C. E., Little, J. B., Lubin, J. H., Preston, D. L., Preston, R. J., Puskin, J. S., Ron, E., Sachs, R. K., Samet, J. M., Setlow, R. B. & Zaider, M. Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proc Natl Acad Sci U S A 100, 13761-13766, doi:10.1073/pnas.2235592100 (2003).
Zhou, H., Randers-Pehrson, G., Geard, C. R., Brenner, D. J., Hall, E. J. & Hei, T. K. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiat Res 160, 512-516 (2003).
Hall, E. J. & Hei, T. K. Genomic instability and bystander effects induced by high-LET radiation. Oncogene 22, 7034-7042, doi:10.1038/sj.onc.1206900 (2003).
Hall, E. J. & Brenner, D. J. The weight of evidence does not support the suggestion that exposure to low doses of X rays increases longevity. Radiology 229, 18-19, doi:10.1148/radiol.2291030990 (2003).
Hopkins, K. M., Wang, X., Berlin, A., Hang, H., Thaker, H. M. & Lieberman, H. B. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. Cancer Res 63, 5291-5298 (2003).
Zhao, Y. L., Piao, C. Q. & Hei, T. K. Tumor suppressor function of Betaig-h3 gene in radiation carcinogenesis. Adv Space Res 31, 1575-1582 (2003).
Roy, D., Calaf, G. & Hei, T. K. Role of Vitamin D receptor gene in radiation-induced neoplastic transformation of human breast epithelial cell. Steroids 68, 621-627 (2003).
Zhou, H., Calaf, G. M. & Hei, T. K. Malignant transformation of human bronchial epithelial cells with the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Int J Cancer 106, 821-826, doi:10.1002/ijc.11319 (2003).
Brenner, D. J. & Sachs, R. K. Domestic radon risks may be dominated by bystander effects--but the risks are unlikely to be greater than we thought. Health Phys 85, 103-108 (2003).
Hall, E. J. The bystander effect. Health Phys 85, 31-35 (2003).
Hall, E. J. & Wuu, C. S. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys 56, 83-88 (2003).
Hande, M. P., Azizova, T. V., Geard, C. R., Burak, L. E., Mitchell, C. R., Khokhryakov, V. F., Vasilenko, E. K. & Brenner, D. J. Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am J Hum Genet 72, 1162-1170, doi:10.1086/375041 (2003).
Brenner, D. J. & Hall, E. J. Mortality patterns in British and US radiologists: what can we really conclude? Br J Radiol 76, 1-2, doi:10.1259/bjr/28107585 (2003).
Brenner, D. J., Sawant, S. G., Hande, M. P., Miller, R. C., Elliston, C. D., Fu, Z., Randers-Pehrson, G. & Marino, S. A. Routine screening mammography: how important is the radiation-risk side of the benefit-risk equation? Int J Radiat Biol 78, 1065-1067, doi:10.1080/0955300021000016576 (2002).
Roy, D., Calaf, G. & Hei, T. K. Allelic imbalance at 11p15.5-15.4 correlated with c-Ha-ras mutation during radiation-induced neoplastic transformation of human breast epithelial cells. Int J Cancer 103, 730-737, doi:10.1002/ijc.10895 (2003).
Zhao, Y. L., Piao, C. Q. & Hei, T. K. Downregulation of Betaig-h3 gene is causally linked to tumorigenic phenotype in asbestos treated immortalized human bronchial epithelial cells. Oncogene 21, 7471-7477, doi:10.1038/sj.onc.1205891 (2002).
Xu, A., Zhou, H., Yu, D. Z. & Hei, T. K. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environ Health Perspect 110, 1003-1008, doi:10.1289/ehp.021101003 (2002).
Hall, E. J. Lessons we have learned from our children: cancer risks from diagnostic radiology. Pediatr Radiol 32, 700-706, doi:10.1007/s00247-002-0774-8 (2002).
Brenner, D. J. & Hall, E. J. Microbeams: a potent mix of physics and biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation Response. Radiat Prot Dosimetry 99, 283-286 (2002).
Geard, C. R., Jenkins-Baker, G., Marino, S. A. & Ponnaiya, B. Novel approaches with track segment alpha particles and cell co-cultures in studies of bystander effects. Radiat Prot Dosimetry 99, 233-236 (2002).
Marino, S. A. & Johnson, G. W. A microdosimetry chamber for low-energy X rays. Radiat Prot Dosimetry 99, 377-378 (2002).
Zhou, H., Randers-Pehrson, G., Suzuki, M., Waldren, C. A. & Hei, T. K. Genotoxic damage in non-irradiated cells: contribution from the bystander effect. Radiat Prot Dosimetry 99, 227-232 (2002).
Kessel, M., Liu, S. X., Xu, A., Santella, R. & Hei, T. K. Arsenic induces oxidative DNA damage in mammalian cells. Mol Cell Biochem 234-235, 301-308 (2002).
Zhao, Y. L., Piao, C. Q. & Hei, T. K. Overexpression of Betaig-h3 gene downregulates integrin alpha5beta1 and suppresses tumorigenicity in radiation-induced tumorigenic human bronchial epithelial cells. Br J Cancer 86, 1923-1928, doi:10.1038/sj.bjc.6600304 (2002).
Brenner, D. J. & Sachs, R. K. Do low dose-rate bystander effects influence domestic radon risks? Int J Radiat Biol 78, 593-604, doi:10.1080/09553000210121740 (2002).
Brenner, D. J. Estimating cancer risks from pediatric CT: going from the qualitative to the quantitative. Pediatr Radiol 32, 228-221; discussion 242-224, doi:10.1007/s00247-002-0671-1 (2002).
Hall, E. J. Introduction to session I: Helical CT and cancer risk. Pediatr Radiol 32, 225-227, doi:10.1007/s00247-002-0670-2 (2002).
Hang, H., Zhang, Y., Dunbrack, R. L., Jr., Wang, C. & Lieberman, H. B. Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. Genomics 79, 487-492, doi:10.1006/geno.2002.6737 (2002).
Sawant, S. G., Zheng, W., Hopkins, K. M., Randers-Pehrson, G., Lieberman, H. B. & Hall, E. J. The radiation-induced bystander effect for clonogenic survival. Radiat Res 157, 361-364 (2002).
Pandita, T. K. ATM function and telomere stability. Oncogene 21, 611-618, doi:10.1038/sj.onc.1205060 (2002).
Hall, E. J. Do no harm--normal tissue effects. Acta Oncol 40, 913-916 (2001).
Brenner, D. J. Is the linear-no-threshold hypothesis appropriate for use in radiation protection? Favouring the proposition. Radiat Prot Dosimetry 97, 279-282; discussion 285 (2001).
Zhou, H., Suzuki, M., Geard, C. R. & Hei, T. K. Effects of irradiated medium with or without cells on bystander cell responses. Mutat Res 499, 135-141 (2002).
Brenner, D. J., Martinez, A. A., Edmundson, G. K., Mitchell, C., Thames, H. D. & Armour, E. P. Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys 52, 6-13 (2002).
Brenner, D. J., Okladnikova, N., Hande, P., Burak, L., Geard, C. R. & Azizova, T. Biomarkers specific to densely-ionising (high LET) radiations. Radiat Prot Dosimetry 97, 69-73 (2001).
Hall, E. J. Genomic instability, bystander effect, cytoplasmic irradiation and other phenomena that may achieve fame without fortune. Phys Med 17 Suppl 1, 21-25 (2001).
Zhou, H., Suzuki, M., Randers-Pehrson, G., Vannais, D., Chen, G., Trosko, J. E., Waldren, C. A. & Hei, T. K. Radiation risk to low fluences of alpha particles may be greater than we thought. Proc Natl Acad Sci U S A 98, 14410-14415, doi:10.1073/pnas.251524798 (2001).
Piao, C. Q., Zhao, Y. L. & Hei, T. K. Analysis of p16 and p21(Cip1) expression in tumorigenic human bronchial epithelial cells induced by asbestos. Oncogene 20, 7301-7306, doi:10.1038/sj.onc.1204908 (2001).
Sawant, S. G., Kozlowski, R. S. & Couch, D. B. The role of adrenal corticosteroids in induction of micronuclei by morphine. Mutat Res 498, 129-133 (2001).
Hei, T. K., Zhao, Y. L., Roy, D., Piao, C. Q., Calaf, G. & Hall, E. J. Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. Adv Space Res 27, 411-419 (2001).
Brenner, D. J. & Elliston, C. D. The potential impact of bystander effects on radiation risks in a Mars mission. Radiat Res 156, 612-617 (2001).
Pandita, T. K. The role of ATM in telomere structure and function. Radiat Res 156, 642-647 (2001).
Roy, D., Calaf, G. & Hei, T. K. Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells. Carcinogenesis 22, 1685-1692 (2001).
Hei, T. K., Piao, C. Q., Wu, L. J., Willey, J. C. & Hall, E. J. Genomic instability and tumorigenic induction in immortalized human bronchial epithelial cells by heavy ions. Adv Space Res 22, 1699-1707 (1998).
Miller, R. C., Martin, S. G., Hanson, W. R., Marino, S. A. & Hall, E. J. Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions. Adv Space Res 22, 1719-1723 (1998).
Roy, D., Calaf, G. & Hei, T. K. Profiling of differentially expressed genes induced by high linear energy transfer radiation in breast epithelial cells. Mol Carcinog 31, 192-203 (2001).
Smilenov, L. B., Brenner, D. J. & Hall, E. J. Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells. Cancer Res 61, 5710-5713 (2001).
Randers-Pehrson, G., Geard, C. R., Johnson, G., Elliston, C. D. & Brenner, D. J. The Columbia University single-ion microbeam. Radiat Res 156, 210-214 (2001).
Sawant, S. G., Randers-Pehrson, G., Metting, N. F. & Hall, E. J. Adaptive response and the bystander effect induced by radiation in C3H 10T(1/2) cells in culture. Radiat Res 156, 177-180 (2001).
Suzuki, M., Piao, C. Q., Zhao, Y. L. & Hei, T. K. Karyotype analysis of tumorigenic human bronchial epithelial cells transformed by chrysolite asbestos using chemically induced premature chromosome condensation technique. Int J Mol Med 8, 43-47 (2001).
Calaf, G., Russo, J. & Alvarado, M. E. Morphological phenotypes in neoplastic progression of benz(alpha)pyrene-treated breast epithelial cells. J Submicrosc Cytol Pathol 32, 535-545 (2000).
Hall, E. J., Miller, R. C. & Brenner, D. J. Radiobiological principles in intravascular irradiation. Cardiovasc Radiat Med 1, 42-47 (1999).
Balajee, A. S. & Geard, C. R. Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res 29, 1341-1351 (2001).
Brenner, D. J. & Miller, R. C. Long-term efficacy of intracoronary irradiation in inhibiting in-stent restenosis. Circulation 103, 1330-1332 (2001).
Brenner, D. J. & Sachs, R. K. Protraction effects in radiation studies: basic biophysics. Radiat Res 154, 736-737 (2000).
Calaf, G. & Hei, T. K. Oncoprotein expression in human breast epithelial cells transformed by high-LET radiation. Int J Radiat Biol 77, 31-40 (2001).
Brenner, D. J., Little, J. B. & Sachs, R. K. The bystander effect in radiation oncogenesis: II. A quantitative model. Radiat Res 155, 402-408 (2001).
Sawant, S. G., Randers-Pehrson, G., Geard, C. R., Brenner, D. J. & Hall, E. J. The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat Res 155, 397-401 (2001).
Suzuki, M., Piao, C., Hall, E. J. & Hei, T. K. Cell killing and chromatid damage in primary human bronchial epithelial cells irradiated with accelerated 56Fe ions. Radiat Res 155, 432-439 (2001).
Liu, S. X., Athar, M., Lippai, I., Waldren, C. & Hei, T. K. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci U S A 98, 1643-1648, doi:10.1073/pnas.031482998 (2001).
Brenner, D., Elliston, C., Hall, E. & Berdon, W. Estimated risks of radiation-induced fatal cancer from pediatric CT. AJR Am J Roentgenol 176, 289-296, doi:10.2214/ajr.176.2.1760289 (2001).
Hall, E. J. Radiation, the two-edged sword: cancer risks at high and low doses. Cancer J 6, 343-350 (2000).
Piao, C. Q. & Hei, T. K. Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ions. Radiat Res 155, 263-267 (2001).
Zhao, Y. L., Piao, C. Q., Hall, E. J. & Hei, T. K. Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. Radiat Res 155, 230-234 (2001).
Zhao, Y. L., Piao, C. Q., Wu, L. J., Suzuki, M. & Hei, T. K. Differentially expressed genes in asbestos-induced tumorigenic human bronchial epithelial cells: implication for mechanism. Carcinogenesis 21, 2005-2010 (2000).
Hang, H., Rauth, S. J., Hopkins, K. M. & Lieberman, H. B. Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control. Nucleic Acids Res 28, 4340-4349 (2000).
Dhar, S., Squire, J. A., Hande, M. P., Wellinger, R. J. & Pandita, T. K. Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability. Mol Cell Biol 20, 7764-7772 (2000).
Pandita, T. K. & Dhar, S. Influence of ATM function on interactions between telomeres and nuclear matrix. Radiat Res 154, 133-139 (2000).
Calaf, G., Russo, J., Tait, L., Estrad, S. & Alvarado, M. E. Morphological phenotypes in neoplastic progression of human breast epithelial cells. J Submicrosc Cytol Pathol 32, 83-96 (2000).
Ansari, R. M. & Hei, T. K. Effects of 60 Hz extremely low frequency magnetic fields (EMF) on radiation- and chemical-induced mutagenesis in mammalian cells. Carcinogenesis 21, 1221-1226 (2000).
Miller, R. C., Marino, S. A., Martin, S. G., Komatsu, K., Geard, C. R., Brenner, D. J. & Hall, E. J. Neutron-energy-dependent cell survival and oncogenic transformation. J Radiat Res 40 Suppl, 53-59 (1999).
Hang, H. & Lieberman, H. B. Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. Genomics 65, 24-33, doi:10.1006/geno.2000.6142 (2000).
Miller, R. C., Marino, S. A., Napoli, J., Shah, H., Hall, E. J., Geard, C. R. & Brenner, D. J. Oncogenic transformation in C3H10T1/2 cells by low-energy neutrons. Int J Radiat Biol 76, 327-333 (2000).
Calaf, G. M. & Hei, T. K. Establishment of a radiation- and estrogen-induced breast cancer model. Carcinogenesis 21, 769-776 (2000).
Pandita, T. K., Lieberman, H. B., Lim, D. S., Dhar, S., Zheng, W., Taya, Y. & Kastan, M. B. Ionizing radiation activates the ATM kinase throughout the cell cycle. Oncogene 19, 1386-1391, doi:10.1038/sj.onc.1203444 (2000).
Zhou, H., Randers-Pehrson, G., Waldren, C. A., Vannais, D., Hall, E. J. & Hei, T. K. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc Natl Acad Sci U S A 97, 2099-2104, doi:10.1073/pnas.030420797 (2000).
Brenner, D. J., Curtis, R. E., Hall, E. J. & Ron, E. Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 88, 398-406 (2000).
Hei, T. K., Xu, A., Louie, D. & Zhao, Y. L. Genotoxicity Versus Carcinogenicity: Implications from Fiber Toxicity Studies. Inhal Toxicol 12 Suppl 3, 141-147, doi:10.1080/08958378.2000.11463207 (2000).

1988-1999 Publications

Xu, A., Wu, L. J., Santella, R. M. & Hei, T. K. Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells. Cancer Res 59, 5922-5926 (1999).
Zhou, H., Zhu, L. X., Li, K. & Hei, T. K. Radon, tobacco-specific nitrosamine and mutagenesis in mammalian cells. Mutat Res 430, 145-153 (1999).
Smilenov, L. B., Dhar, S. & Pandita, T. K. Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. Mol Cell Biol 19, 6963-6971 (1999).
Hall, E. Commentary on Roebuck DJ: "Risk and benefit in paediatric radiology". Pediatr Radiol 29, 721-722, doi:10.1007/s002470050681 (1999).
Piao, C. Q., Willey, J. C. & Hei, T. K. Alterations of p53 in tumorigenic human bronchial epithelial cells correlate with metastatic potential. Carcinogenesis 20, 1529-1533 (1999).
Rakovitch, E., Mellado, W., Hall, E. J., Pandita, T. K., Sawant, S. & Geard, C. R. Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation. Int J Radiat Oncol Biol Phys 44, 1119-1124 (1999).
Johnson, K. L., Brenner, D. J., Geard, C. R., Nath, J. & Tucker, J. D. Chromosome aberrations of clonal origin in irradiated and unexposed individuals: assessment and implications. Radiat Res 152, 1-5 (1999).
Sawant, S. G., Gregoire, V., Dhar, S., Umbricht, C. B., Cvilic, S., Sukumar, S. & Pandita, T. K. Telomerase activity as a measure for monitoring radiocurability of tumor cells. FASEB J 13, 1047-1054 (1999).
Wu, L. J., Randers-Pehrson, G., Xu, A., Waldren, C. A., Geard, C. R., Yu, Z. & Hei, T. K. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proc Natl Acad Sci U S A 96, 4959-4964 (1999).
Brenner, D. J. & Hall, E. J. Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 43, 1095-1101 (1999).
Johnson, K. L., Brenner, D. J., Nath, J., Tucker, J. D. & Geard, C. R. Radiation-induced breakpoint misrejoining in human chromosomes: random or non-random? Int J Radiat Biol 75, 131-141 (1999).
Brenner, D. J., Leu, C. S., Beatty, J. F. & Shefer, R. E. Clinical relative biological effectiveness of low-energy x-rays emitted by miniature x-ray devices. Phys Med Biol 44, 323-333 (1999).
Brenner, D. J. Does fractionation decrease the risk of breast cancer induced by low-LET radiation? Radiat Res 151, 225-229 (1999).
Brenner, D. J. The relative effectiveness of exposure to 131I at low doses. Health Phys 76, 180-185 (1999).
Miller, R. C., Randers-Pehrson, G., Geard, C. R., Hall, E. J. & Brenner, D. J. The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc Natl Acad Sci U S A 96, 19-22 (1999).
Rakovitch, E., Mellado, W., Hall, E. J., Sawant, S. G., Geard, C. R., Newman, R. A. & Pandita, T. K. Penclomedine-induced DNA fragmentation and p53 accumulation correlate with reproductive cell death in colorectal carcinoma cells with altered p53 status. Oncol Rep 6, 161-165 (1999).
Hall, E. J., Schiff, P. B., Hanks, G. E., Brenner, D. J., Russo, J., Chen, J., Sawant, S. G. & Pandita, T. K. A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J Sci Am 4, 385-389 (1998).
Smilenov, L. B., Mellado, W., Rao, P. H., Sawant, S. G., Umbricht, C. B., Sukumar, S. & Pandita, T. K. Molecular cloning and chromosomal localization of Chinese hamster telomeric protein chTRF1. Its potential role in chromosomal instability. Oncogene 17, 2137-2142, doi:10.1038/sj.onc.1202138 (1998).
Hang, H., Rauth, S. J., Hopkins, K. M., Davey, S. K. & Lieberman, H. B. Molecular cloning and tissue-specific expression of Mrad9, a murine orthologue of the Schizosaccharomyces pombe rad9+ checkpoint control gene. J Cell Physiol 177, 241-247, doi:10.1002/(SICI)1097-4652(199811)177:2<241::AID-JCP6>3.0.CO;2-N (1998).
Hall, E. J. From chimney sweeps to astronauts: cancer risks in the work place: the 1998 Lauriston Taylor lecture. Health Phys 75, 357-366 (1998).
Hei, T. K., Liu, S. X. & Waldren, C. Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species. Proc Natl Acad Sci U S A 95, 8103-8107 (1998).
Brenner, D. J., Hlatky, L. R., Hahnfeldt, P. J., Huang, Y. & Sachs, R. K. The linear-quadratic model and most other common radiobiological models result in similar predictions of time-dose relationships. Radiat Res 150, 83-91 (1998).
Randers-Pehrson, G. & Brenner, D. J. A practical target system for accelerator-based BNCT which may effectively double the dose rate. Med Phys 25, 894-896, doi:10.1118/1.598266 (1998).
Brenner, D., Armour, E., Corry, P. & Hall, E. Sublethal damage repair times for a late-responding tissue relevant to brachytherapy (and external-beam radiotherapy): implications for new brachytherapy protocols. Int J Radiat Oncol Biol Phys 41, 135-138 (1998).
Hei, T. K., Wu, L. J. & Piao, C. Q. Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers. Environ Health Perspect 105 Suppl 5, 1085-1088, doi:10.1289/ehp.97105s51085 (1997).
Smilenov, L. B., Morgan, S. E., Mellado, W., Sawant, S. G., Kastan, M. B. & Pandita, T. K. Influence of ATM function on telomere metabolism. Oncogene 15, 2659-2665, doi:10.1038/sj.onc.1201449 (1997).
Brenner, D. J., Schiff, P. B., Huang, Y. & Hall, E. J. Pulsed-dose-rate brachytherapy: design of convenient (daytime-only) schedules. Int J Radiat Oncol Biol Phys 39, 809-815 (1997).
Hall, E. J. & Brenner, D. J. Pulsed dose-rate brachytherapy. Radiother Oncol 45, 1-2 (1997).
Brenner, D. J. & Herbert, D. E. The use of the linear-quadratic model in clinical radiation oncology can be defended on the basis of empirical evidence and theoretical argument. Med Phys 24, 1245-1248, doi:10.1118/1.598086 (1997).
Hall, E. J. What will molecular biology contribute to our understanding of radiation-induced cell killing and carcinogenesis? Int J Radiat Biol 71, 667-674 (1997).
Brenner, D. J. Radiation biology in brachytherapy. J Surg Oncol 65, 66-70 (1997).
Hei, T. K., Wu, L. J., Liu, S. X., Vannais, D., Waldren, C. A. & Randers-Pehrson, G. Mutagenic effects of a single and an exact number of alpha particles in mammalian cells. Proc Natl Acad Sci U S A 94, 3765-3770 (1997).
Chen, C. Z., Huang, Y., Hall, E. J. & Brenner, D. J. Pulsed brachytherapy as a substitute for continuous low dose rate: an in vitro study with human carcinoma cells. Int J Radiat Oncol Biol Phys 37, 137-143 (1997).
Lieberman, H. B., Hopkins, K. M., Nass, M., Demetrick, D. & Davey, S. A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. Proc Natl Acad Sci U S A 93, 13890-13895 (1996).
Brenner, D. J., Miller, R. C. & Hall, E. J. The radiobiology of intravascular irradiation. Int J Radiat Oncol Biol Phys 36, 805-810 (1996).
Minarik, L., Hall, E. & Miller, R. Tumorigenicity, oncogene transfection, and radiosensitivity. Cancer J Sci Am 2, 351-355 (1996).
Freyer, G. A., Palmer, D. A., Yu, Y., Miller, R. C. & Pandita, T. K. Neoplastic transformation of mouse C3H10T1/2 cells following exposure to neutrons does not involve mutation of ras gene as analyzed by SSCP and cycle sequencing. Mutat Res 357, 237-244 (1996).
Pandita, T. K., Hall, E. J., Hei, T. K., Piatyszek, M. A., Wright, W. E., Piao, C. Q., Pandita, R. K., Willey, J. C., Geard, C. R., Kastan, M. B. & Shay, J. W. Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. Oncogene 13, 1423-1430 (1996).
Brenner, D. J., Hahnfeldt, P., Amundson, S. A. & Sachs, R. K. Interpretation of inverse dose-rate effects for mutagenesis by sparsely ionizing radiation. Int J Radiat Biol 70, 447-458 (1996).
Hei, T. K., Liu, S. X. & Hall, E. J. Oncogenic potential of bifunctional bioreductive drugs. Br J Cancer Suppl 27, S57-60 (1996).
Miller, R. C., Richards, M., Brenner, D. J., Hall, E. J., Jostes, R., Hui, T. E. & Brooks, A. L. The biological effectiveness of radon-progeny alpha particles. V. Comparison of oncogenic transformation by accelerator-produced monoenergetic alpha particles and by polyenergetic alpha particles from radon progeny. Radiat Res 146, 75-80 (1996).
Geard, C. R. Neutron induced recoil protons of restricted energy and range and biological effectiveness. Health Phys 70, 804-811 (1996).
Pandita, T. K. & Geard, C. R. Chromosome aberrations in human fibroblasts induced by monoenergetic neutrons. I. Relative biological effectiveness. Radiat Res 145, 730-739 (1996).
Hang, H., Hager, D. N., Goriparthi, L., Hopkins, K. M., Shih, H. & Lieberman, H. B. Schizosaccharomyces pombe rad23 is allelic with swi10, a mating-type switching/radioresistance gene that shares sequence homology with human and mouse ERCC1. Gene 170, 113-117 (1996).
Brenner, D. J. Direct biological evidence for a significant neutron dose to survivors of the Hiroshima atomic bomb. Radiat Res 145, 501-507 (1996).
Zaider, M. The combined effects of sublethal damage repair, cellular repopulation and redistribution in the mitotic cycle. II. The dependency of radiosensitivity parameters alpha, beta and t(0) on biological age for Chinese hamster V79 cells. Radiat Res 145, 467-473 (1996).
Zaider, M., Wuu, C. S. & Minerbo, G. N. The combined effects of sublethal damage repair, cellular repopulation and redistribution in the mitotic cycle. I. Survival probabilities after exposure to radiation. Radiat Res 145, 457-466 (1996).
Brenner, D. J., Hall, E. J., Randers-Pehrson, G., Huang, Y., Johnson, G. W., Miller, R. W., Wu, B., Vazquez, M. E., Medvedovsky, C. & Worgul, B. V. Quantitative comparisons of continuous and pulsed low dose rate regimens in a model late-effect system. Int J Radiat Oncol Biol Phys 34, 905-910 (1996).
Zhu, L. X., Waldren, C. A., Vannias, D. & Hei, T. K. Cellular and molecular analysis of mutagenesis induced by charged particles of defined linear energy transfer. Radiat Res 145, 251-259 (1996).
Suzuki, K. & Hei, T. K. Mutation induction in gamma-irradiated primary human bronchial epithelial cells and molecular analysis of the HPRT- mutants. Mutat Res 349, 33-41 (1996).
Hall, E. J. Neutrons and carcinogenesis: a cautionary tale. Bull Cancer Radiother 83 Suppl, 43s-46s (1996).
Hei, T. K., Piao, C. Q., Sutter, T., Willey, J. C. & Suzuki, K. Cellular and molecular alterations in human epithelial cells transformed by high LET radiation. Adv Space Res 18, 137-148 (1996).
Lieberman, H. B. Extragenic suppressors of Schizosaccharomyces pombe rad9 mutations uncouple radioresistance and hydroxyurea sensitivity from cell cycle checkpoint control. Genetics 141, 107-117 (1995).
Hall, E. J., Martin, S. G., Amols, H. & Hei, T. K. Photoneutrons from medical linear accelerators--radiobiological measurements and risk estimates. Int J Radiat Oncol Biol Phys 33, 225-230, doi:10.1016/0360-3016(95)00092-D (1995).
Freyer, G. A., Davey, S., Ferrer, J. V., Martin, A. M., Beach, D. & Doetsch, P. W. An alternative eukaryotic DNA excision repair pathway. Mol Cell Biol 15, 4572-4577 (1995).
Hei, T. K., He, Z. Y. & Suzuki, K. Effects of antioxidants on fiber mutagenesis. Carcinogenesis 16, 1573-1578 (1995).
Miller, R. C., Geard, C. R., Martin, S. G., Marino, S. A. & Hall, E. J. Neutron-induced cell cycle-dependent oncogenic transformation of C3H 10T1/2 cells. Radiat Res 142, 270-275 (1995).
Brenner, D. J., Hlatky, L. R., Hahnfeldt, P. J., Hall, E. J. & Sachs, R. K. A convenient extension of the linear-quadratic model to include redistribution and reoxygenation. Int J Radiat Oncol Biol Phys 32, 379-390, doi:10.1016/0360-3016(95)00544-9 (1995).
Zhao, Y. & Lieberman, H. B. Schizosaccharomyces pombe: a model for molecular studies of eukaryotic genes. DNA Cell Biol 14, 359-371, doi:10.1089/dna.1995.14.359 (1995).
Geard, C. R. & Jenkins, G. Human chromosome-specific changes in a human-hamster hybrid cell line (AL) assessed by fluorescent in situ hybridization (FISH). Int J Radiat Oncol Biol Phys 32, 113-120, doi:10.1016/0360-3016(94)00487-6 (1995).
Brenner, D. J., Miller, R. C., Huang, Y. & Hall, E. J. The biological effectiveness of radon-progeny alpha particles. III. Quality factors. Radiat Res 142, 61-69 (1995).
Martin, S. G., Miller, R. C., Geard, C. R. & Hall, E. J. The biological effectiveness of radon-progeny alpha particles. IV. Morphological transformation of Syrian hamster embryo cells at low doses. Radiat Res 142, 70-77 (1995).
Miller, R. C., Marino, S. A., Brenner, D. J., Martin, S. G., Richards, M., Randers-Pehrson, G. & Hall, E. J. The biological effectiveness of radon-progeny alpha particles. II. Oncogenic transformation as a function of linear energy transfer. Radiat Res 142, 54-60 (1995).
Kliauga, P. & Amols, H. Photoneutrons from high energy medical linear accelerators: measurement of the spectrum and dose using a miniature proportional counter. Int J Radiat Oncol Biol Phys 31, 629-633, doi:10.1016/0360-3016(94)00370-Z (1995).
Kahn, S. M., Jiang, W., Weinstein, I. B. & Perucho, M. Diagnostic detection of mutant ras genes in minor cell populations. Methods Enzymol 255, 452-464 (1995).
Pandita, T. K., Pathak, S. & Geard, C. R. Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet Cell Genet 71, 86-93, doi:10.1159/000134069 (1995).
Zaider, M. & Wuu, C. S. The effects of sublethal damage recovery and cell cycle progression on the survival probability of cells exposed to radioactive sources. Br J Radiol 68, 58-63, doi:10.1259/0007-1285-68-805-58 (1995).
Lieberman, H. B. & Hopkins, K. M. Schizosaccharomyces malidevorans and Sz. octosporus homologues of Sz. pombe rad9, a gene that mediates radioresistance and cell-cycle progression. Gene 150, 281-286 (1994).
Hall, E. J. Molecular biology in radiation therapy: the potential impact of recombinant technology on clinical practice. Int J Radiat Oncol Biol Phys 30, 1019-1028 (1994).
Brenner, D. J. & Sachs, R. K. Chromosomal "fingerprints" of prior exposure to densely ionizing radiation. Radiat Res 140, 134-142 (1994).
Hei, T. K., Zhu, L. X., Vannais, D. & Waldren, C. A. Molecular analysis of mutagenesis by high LET radiation. Adv Space Res 14, 355-361 (1994).
Minarik, L. & Hall, E. J. Taxol in combination with acute and low dose rate irradiation. Radiother Oncol 32, 124-128 (1994).
Brenner, D. J. The significance of dose rate in assessing the hazards of domestic radon exposure. Health Phys 67, 76-79 (1994).
Brenner, D. J., Hall, E. J., Huang, Y. & Sachs, R. K. Optimizing the time course of brachytherapy and other accelerated radiotherapeutic protocols. Int J Radiat Oncol Biol Phys 29, 893-901 (1994).
Loucas, B. D. & Geard, C. R. Initial damage in human interphase chromosomes from alpha particles with linear energy transfers relevant to radon exposure. Radiat Res 139, 9-14 (1994).
Geard, C. R. & Jones, J. M. Radiation and taxol effects on synchronized human cervical carcinoma cells. Int J Radiat Oncol Biol Phys 29, 565-569 (1994).
Loucas, B. D. & Geard, C. R. Kinetics of chromosome rejoining in normal human fibroblasts after exposure to low- and high-LET radiations. Radiat Res 138, 352-360 (1994).
Hei, T. K., Piao, C. Q., Geard, C. R. & Hall, E. J. Taxol and ionizing radiation: interaction and mechanisms. Int J Radiat Oncol Biol Phys 29, 267-271 (1994).
Grobelsek-Vracko, M. & Zaider, M. A study of the excited states in cytosine and guanine stacks in the Hartree-Fock and exciton approximations. Radiat Res 138, 18-25 (1994).
Hei, T. K., Piao, C. Q., Willey, J. C., Thomas, S. & Hall, E. J. Malignant transformation of human bronchial epithelial cells by radon-simulated alpha-particles. Carcinogenesis 15, 431-437 (1994).
Hei, T. K., Krauss, R. S., Liu, S. X., Hall, E. J. & Weinstein, I. B. Effects of increased expression of protein kinase C on radiation-induced cell transformation. Carcinogenesis 15, 365-370 (1994).
Brenner, D. J., Ward, J. F. & Sachs, R. K. Track structure, chromosome geometry and chromosome aberrations. Basic Life Sci 63, 93-109; discussion 109-113 (1994).
Geard, C. R., Miller, R. C., Brenner, D. J. & Hall, E. J. Oncogenic transformation through the cell cycle and the LET dependent inverse dose rate effect. Radiat Prot Dosimetry 52, 367-371 (1994).
Hittelman, W. N. & Pandita, T. K. Possible Role of Chromatin Alteration in the Radiosensitivity of Ataxia-telangiectasia. Int J Radiat Biol 66, S109-S113, doi:10.1080/09553009414551931 (1994).
Miller, R. C., Richards, M., Baird, C., Martin, S. & Hall, E. J. Interaction of hyperthermia and chemotherapy agents; cell lethality and oncogenic potential. Int J Hyperthermia 10, 89-99 (1994).
Zaider, M., Fung, A. & Bardash, M. Charged-particle transport in biomolecular media: the third generation. Basic Life Sci 63, 77-91; discussion 91-72 (1994).
Brenner, D. J. The influence of cell killing on radiation oncogenesis: possible implications for high-let risk assessment at medium doses. Health Phys 65, 358-366 (1993).
Zhao, Y., Hopkins, K. M. & Lieberman, H. B. A method for the preparation and storage of frozen, competent Schizosaccharomyces pombe spheroplasts. Biotechniques 15, 238 (1993).
Hall, E. J. The Janeway Lecture 1992. Nine decades of radiobiology: is radiation therapy any the better for it? Cancer 71, 3753-3766 (1993).
Geard, C. R. Induction of sister chromatid exchange as a function of charged-particle linear energy transfer. Radiat Res 134, 187-192 (1993).
Brenner, D. J. Dose, volume, and tumor-control predictions in radiotherapy. Int J Radiat Oncol Biol Phys 26, 171-179 (1993).
Zaider, M. A mathematical formalism describing the yield of radiation-induced single- and double-strand DNA breaks, and its dependence on radiation quality. Radiat Res 134, 1-8 (1993).
Hei, T. K. & Hall, E. J. Taxol, radiation, and oncogenic transformation. Cancer Res 53, 1368-1372 (1993).
Brenner, D. J., Hall, E. J., Randers-Pehrson, G. & Miller, R. C. Mechanistic considerations on the dose-rate/LET dependence of oncogenic transformation by ionizing radiations. Radiat Res 133, 365-369 (1993).
Miller, R. C., Randers-Pehrson, G., Hieber, L., Marino, S. A., Richards, M. & Hall, E. J. The inverse dose-rate effect for oncogenic transformation by charged particles is dependent on linear energy transfer. Radiat Res 133, 360-364 (1993).
Piao, C. Q. & Hei, T. K. The biological effectiveness of radon daughter alpha particles. I. Radon, cigarette smoke and oncogenic transformation. Carcinogenesis 14, 497-501 (1993).
Brenner, D. J., Medvedovsky, C., Huang, Y. & Worgul, B. V. Accelerated heavy particles and the lens. VIII. Comparisons between the effects of acute low doses of iron ions (190 keV/microns) and argon ions (88 keV/microns). Radiat Res 133, 198-203 (1993).
Geard, C. R., Jones, J. M. & Schiff, P. B. Taxol and radiation. J Natl Cancer Inst Monogr, 89-94 (1993).
Hall, E. J. The gene as theme in the paradigm of cancer. Br J Radiol 66, 1-11, doi:10.1259/0007-1285-66-781-1 (1993).
Zaider, M. & Minerbo, G. N. A mathematical model for cell cycle progression under continuous low-dose-rate irradiation. Radiat Res 133, 20-26 (1993).
Sidik, K., Lieberman, H. B. & Freyer, G. A. Repair of DNA damaged by UV light and ionizing radiation by cell-free extracts prepared from Schizosaccharomyces pombe. Proc Natl Acad Sci U S A 89, 12112-12116 (1992).
Hei, T. K., Piao, C. Q., He, Z. Y., Vannais, D. & Waldren, C. A. Chrysotile fiber is a strong mutagen in mammalian cells. Cancer Res 52, 6305-6309 (1992).
Brenner, D. J. Correlations between alpha/beta and T1/2: implications for clinical biological modelling. Br J Radiol 65, 1051-1054, doi:10.1259/0007-1285-65-779-1051 (1992).
Rossi, H. H. & Zaider, M. Compound dual radiation action. I. General aspects. Radiat Res 132, 178-183 (1992).
Hall, E. J. & Brenner, D. J. The 1991 George Edelstyn Memorial Lecture: needles, wires and chips--advances in brachytherapy. Clin Oncol (R Coll Radiol) 4, 249-256 (1992).
Brenner, D. J. & Ward, J. F. Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int J Radiat Biol 61, 737-748 (1992).
Miller, R. C., Geard, C. R., Geard, M. J. & Hall, E. J. Cell-cycle-dependent radiation-induced oncogenic transformation of C3H 10T1/2 cells. Radiat Res 130, 129-133 (1992).
Zaider, M. & Rossi, H. H. On the question of RBE reversal at high doses. Radiat Res 130, 117-120 (1992).
Hall, E. J. Failla Memorial Lecture. From beans to genes--back to the future. Radiat Res 129, 235-249 (1992).
Hall, E. J. & Brenner, D. J. The dose-rate effect in interstitial brachytherapy: a controversy resolved. Br J Radiol 65, 242-247, doi:10.1259/0007-1285-65-771-242 (1992).
Brenner, D. J. Radon: current challenges in cellular radiobiology. Int J Radiat Biol 61, 3-13 (1992).
Brenner, D. J. & Hall, E. J. Commentary 2 to Cox and Little: radiation-induced oncogenic transformation: the interplay between dose, dose protraction, and radiation quality. Adv Radiat Biol 16, 167-179 (1992).
Geard, C. R. Cytogenetic assays for genotoxic agents. Lens Eye Toxic Res 9, 413-428 (1992).
Hall, E. J., Astor, M. & Brenner, D. J. Biological intercomparisons of neutron beams used for radiotherapy generated by p(+)-->Be in hospital-based cyclotrons. Br J Radiol 65, 66-71, doi:10.1259/0007-1285-65-769-66 (1992).
Hall, E. J. & Denekemp, J. Residency training in radiation oncology; radiation biology and cancer biology. Int J Radiat Oncol Biol Phys 24, 847-849 (1992).
Hall, E. J. & Hei, T. K. Oncogenic transforming potential of etanidazole. Int J Radiat Oncol Biol Phys 22, 743-745 (1992).
Hei, T. K., Piao, C. Q., He, Z. Y. & Hall, E. J. Mechanism of oncogenicity for bioreductive drugs. Int J Radiat Oncol Biol Phys 22, 747-750 (1992).
Brenner, D. J., Huang, Y. & Hall, E. J. Fractionated high dose-rate versus low dose-rate regimens for intracavitary brachytherapy of the cervix: equivalent regimens for combined brachytherapy and external irradiation. Int J Radiat Oncol Biol Phys 21, 1415-1423 (1991).
Hall, E. J. & Brenner, D. J. The dose-rate effect revisited: radiobiological considerations of importance in radiotherapy. Int J Radiat Oncol Biol Phys 21, 1403-1414 (1991).
Zaider, M. Evidence of a neutron RBE of 70 (+/- 50) for solid-tumor induction at Hiroshima and Nagasaki and its implications for assessing the effective neutron quality factor. Health Phys 61, 631-636 (1991).
Brenner, D. J., Medvedovsky, C., Huang, Y., Merriam, G. R., Jr. & Worgul, B. V. Accelerated heavy particles and the lens. VI. RBE studies at low doses. Radiat Res 128, 73-81 (1991).
Hall, E. J., Miller, R. C. & Brenner, D. J. Neoplastic transformation and the inverse dose-rate effect for neutrons. Radiat Res 128, S75-80 (1991).
Miller, R. C. & Hall, E. J. Oncogenic transformation of C3H 10T1/2 cells by acute and protracted exposures to monoenergetic neutrons. Radiat Res 128, S60-64 (1991).
Hall, E. J. Scientific view of low-level radiation risks. Radiographics 11, 509-518, doi:10.1148/radiographics.11.3.1852943 (1991).
Hall, E. J. From chimney sweeps to oncogenes: the quest for the causes of cancer. Radiology 179, 297-306, doi:10.1148/radiology.179.2.2014268 (1991).
Steinberg, S. F., Robinson, R. B., Lieberman, H. B., Stern, D. M. & Rosen, M. R. Thrombin modulates phosphoinositide metabolism, cytosolic calcium, and impulse initiation in the heart. Circ Res 68, 1216-1229 (1991).
Roizin-Towle, L. & Pirro, J. P. The response of human and rodent cells to hyperthermia. Int J Radiat Oncol Biol Phys 20, 751-756 (1991).
Brenner, D. J. Significance of neutrons from the atomic bomb at Hiroshima for revised radiation risk estimates. Health Phys 60, 439-442 (1991).
Hall, E. J. Weiss lecture. The dose-rate factor in radiation biology. Int J Radiat Biol 59, 595-610 (1991).
Miller, R. C., Geard, C. R., Marino, S. A., Richards, M. & Randers-Pehrson, G. Oncogenic transformation following sequential irradiations with monoenergetic neutrons and X rays. Radiat Res 125, 338-342 (1991).
Brenner, D. J. & Hall, E. J. Fractionated high dose rate versus low dose rate regimens for intracavitary brachytherapy of the cervix. I. General considerations based on radiobiology. Br J Radiol 64, 133-141, doi:10.1259/0007-1285-64-758-133 (1991).
Brenner, D. J. & Hall, E. J. Conditions for the equivalence of continuous to pulsed low dose rate brachytherapy. Int J Radiat Oncol Biol Phys 20, 181-190 (1991).
Hall, E. J. & Freyer, G. A. The molecular biology of radiation carcinogenesis. Basic Life Sci 58, 3-19; discussion 19-25 (1991).
Zaider, M. Charged-particle transport in the condensed phase. Basic Life Sci 58, 137-160; discussion 160-132 (1991).
Brenner, D. J. & Hall, E. J. The inverse dose-rate effect for oncogenic transformation by neutrons and charged particles: a plausible interpretation consistent with published data. Int J Radiat Biol 58, 745-758 (1990).
Hall, E. J. & Brenner, D. J. In vitro effects of high-LET radiation. Int J Radiat Biol 58, 877-880 (1990).
Brenner, D. J. Track structure, lesion development, and cell survival. Radiat Res 124, S29-37 (1990).
Geard, C. R. & Chen, C. Y. Micronuclei and clonogenicity following low- and high-dose-rate gamma irradiation of normal human fibroblasts. Radiat Res 124, S56-61 (1990).
Hei, T. K., He, Z. Y., Piao, C. Q. & Hall, E. J. Studies with bifunctional bioreductive drugs. I. In vitro oncogenic transforming potential. Radiat Res 124, S44-49 (1990).
Kliauga, P. Microdosimetry at middle age: some old experimental problems and new aspirations. Radiat Res 124, S5-15 (1990).
Miller, R. C., Brenner, D. J., Randers-Pehrson, G., Marino, S. A. & Hall, E. J. The effects of the temporal distribution of dose on oncogenic transformation by neutrons and charged particles of intermediate LET. Radiat Res 124, S62-68 (1990).
Roizin-Towle, L., Pirro, J. P. & Hall, E. J. Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin. Radiat Res 124, S50-55 (1990).
Roizin-Towle, L., Yarlett, N., Pirro, J. P. & Delohery, T. M. Hyperthermia studies in polyamine-altered human lung carcinoma cells. Radiat Res 124, S80-87 (1990).
Zaider, M. Microdosimetry and Katz's track structure theory. I. One-hit detectors. Radiat Res 124, S16-22 (1990).
Zaider, M. Concepts for describing the interaction of two agents. Radiat Res 123, 257-262 (1990).
Hall, E. J. & Hei, T. K. Modulating factors in the expression of radiation-induced oncogenic transformation. Environ Health Perspect 88, 149-155, doi:10.1289/ehp.9088149 (1990).
Brenner, D. J. & Quan, H. Confidence limits for low induced frequencies of oncogenic transformation in the presence of a background. Int J Radiat Biol 57, 1031-1045 (1990).
Rossi, H. H. & Zaider, M. Contribution of neutrons to the biological effects in Hiroshima. Health Phys 58, 645-647 (1990).
Lieberman, H. B., Riley, R. & Martel, M. Isolation and initial characterization of a Schizosaccharomyces pombe mutant exhibiting temperature-dependent radiation sensitivity due to a mutation in a previously unidentified rad locus. Mol Gen Genet 218, 554-558 (1989).
Rubin, J. S. Effect of gamma rays on efficiency of gene transfer in DNA repair-proficient and -deficient cell lines. Somat Cell Mol Genet 14, 613-621 (1988).
Rubin, J. S. The molecular genetics of the incision step in the DNA excision repair process. Int J Radiat Biol 54, 309-365 (1988).