RARAF Publications
Publications From Experiments Involving RARAF
During the more than four decades that RARAF has been in operation, experiments have been performed for over 50 different research groups from more than 40 institutions including universities, national laboratories, cancer centers, and private corporations. These experiments, performed with particulate radiations such as protons, alpha particles and neutrons, have resulted in more than 200 publications in refereed journals, proceedings, and books. Research has been conducted in the fields of radiation biology, radiological physics, radiation chemistry, health physics, and medicine.
Complete list of RARAF publications(link is external and opens in a new window)
Recent Publications
Bertolet A, Grilj V, Guardiola C, Harken AD, Cortés-Giraldo MA, Baratto-Roldán A, Fleta C, Lozano M, Carabe A. Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a silicon-based microdosimeter. Radiation Physics and Chemistry. 2020;176:109060 PMCID: PMC in process.
Ye LF, Chaudhary KR, Zandkarimi F, Harken AD, Kinslow CJ, Upadhyayula PS, Dovas A, Higgins DM, Tan H, Zhang Y, Buonanno M, Wang TJC, Hei TK, Bruce JN, Canoll PD, Cheng SK, Stockwell BR. Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers. ACS Chemical Biology. 2020;15:469-84 PMCID: PMC7180072
Shang J, Welch D, Buonanno M, Ponnaiya B, Garty G, Olsen T, Amundson SA, Lin Q. An Integrated Preprocessing Approach for Exploring Single-Cell Gene Expression in Rare Cells. Sci Rep. 2019;9:19758 PMCID: PMC6930255.
Mukherjee S, Grilj V, Broustas CG, Ghandhi SA, Harken AD, Garty G, and Amundson SA (2019) Human Transcriptomic Response to Mixed Neutron-Photon Exposures Relevant to an Improvised Nuclear Device. Radiat Res. 192: 189-199. PMC7450517
Barbieri S, Baiocco G, Babini G, Morini J, Friedland W, Buonanno M, Grilj V, Brenner DJ, Ottolenghi A. Modelling γ-H2AX foci induction to mimic limitations in the scoring technique. Radiat Prot Dosimetry. 2019;183:121-5 PMCID: PMC6525333.
Barbieri S, Babini G, Morini J, Friedland W, Buonanno M, Grilj V, Brenner DJ, Ottolenghi A, Baiocco G. Predicting DNA damage foci and their experimental readout with 2D microscopy: a unified approach applied to photon and neutron exposures. Scientific reports. 2019;9:14019- PMCID: PMC6769049.
Broustas CG, Harken AD, Garty G, and Amundson SA (2018) Identification of differentially expressed genes and pathways in mice exposed to mixed field neutron/photon radiation. BMC Genomics. 19: 504. PMCID: PMC6027792
Amundson SA (2018) Gene Expression Studies for the Development of Particle Therapy. Int J Part Ther. 5: 49-59. PMCID: PMC6292674
Grilj V, Brenner DJ. LET dependent response of GafChromic films investigated with MeV ion beams. Phys Med Biol. 2018;63:245021. PMCID: PMC in process
Biology articles involving outside scientists.
Azzam, E.I., de Toledo, S.M., Harris, A.L., Ivanov, V., Zhou, H., Amundson, S.A., Lieberman, H.B. and Hei, T.K. The ionizing radiation-induced bystander effect: Evidence, mechanism, and significance. Pathobiology of Cancer Regimen-Related Toxicities, Sonis, S.T., and Keefe, D.M., eds., pp.35-61. Springer, New York, NY, 2013. (Book chapter).
Riquier, H. “Étude des effets de radiations par rayons X ou par particules alpha sur les interactions entre cellules tumorales et cellules éndotheliales” (University of Namur, Belgium Ph. D. Thesis), 2013.
Miller A.C., Development of Models to Study Radiation Late Effects and Identify Mechanism-Responsive Biological Countermeasures, NATO HFM-223 Technical Report Oct. 2012.
Hu, B., Grabham, P., Nie, J., Balajee, A.S., Zhou, H., Hei, T.K. and Geard, C.R. Intrachromosomal changes and genomic instability in site-specific microbeam-irradiated and bystander human-hamster hybrid cells. Radiat. Res. 177, 25-34 (2012), PMCID: PMC3410536. [Full Text(link is external and opens in a new window)]
Kovalchuk O., Zemp F., Filkowski J., Altamirano A., Dickey J.S., Jenkins-Baker G., Marino S.A., Brenner D.J., Bonner W.M. and Sedelnikova O.A. MicroRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways. Carcinogenesis.31:1882-1888 (2010), PMCID: PMC2950932. [abstract(link is external and opens in a new window)] [PDF]
Schettino G., Johnson G.W., Marino S.A., Brenner D.J. Development of a method for assessing non-targeted radiation damage in an artificial 3D human skin model. Int. J. Radiat. Biol.86:593-601 (2010), PMCID: PMC3228351. [abstract(link is external and opens in a new window)] [PDF]
Bertucci, A., Pocock, R.D., Randers-Pehrson, G. and Brenner, D.J. Microbeam irradiation of the C. elegans nematode. J Radiat Res (Tokyo) 50 Suppl A: A49-54, (2009), PubMed - indexed for MEDLINE. [abstract(link is external and opens in a new window)] [PDF]
Bailey S.M. Michael Fry Research Award lecture: Telomeres and double-strand breaks - all's well that "ends" well. Radiat Res. 169: 1-7 (2008), PubMed - indexed for MEDLINE. [abstract(link is external and opens in a new window)] [PDF]
Bailey S.M. and Cornforth M.N. Telomeres and DNA double-strand breaks: ever the twain shall meet? Cell Mol Life Sci. 64: 2956-2964 (2007). [abstract(link is external and opens in a new window)] [PDF]
Li H., Gu Y., Miki J., Hukku B., McLeod D.G., Hei T.K. and Rhim JS. Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles. Int J Oncol. 31: 537-544 (2007). [abstract(link is external and opens in a new window)]
Koh E.S., Tran T.H., Heydarian M., Sachs R.K., Tsang R.W., Brenner D.J., Pintilie M., Xu T., Chung J., Paul N., Hodgson D.C., A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk. Radiat Oncol. 2: 13 (2007). [abstract(link is external and opens in a new window)] [PDF]
Miller A.C., Stewart M., Rivas R., Marino S., Randers-Pehrson G., and Shi L., Observation of radiation-specific damage in cells exposed to depleted uranium: hprt gene mutation frequency. Radiat. Meas. 42: 1029-1032 (2007). [PDF]
Sedelnikova O.A., Nakamura A., Kovalchuk O.,Koturbash I., Mitchell S.A., Marino S.A., Brenner D.J., Bonner W.M., DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res. 67: 4295-4302 (2007). [abstract(link is external and opens in a new window)] [PDF]
Williams E.S., Stap J., Essers J., Ponnaiya B., Luijsterburg M.S., Krawczyk P.M., Ullrich R.L., Aten J.A. and Bailey S.M., DNA double strand breaks are not sufficient to initiate the recruitment of TRF2. Nat. Genet 39: 696-698 (2007).[PDF]
Zhou H., Xu A., Gillispie J.A., Waldren C.A. and Hei T.K. Quantification of CD59(-) mutants in human-hamster hybrid (A(L)) cells by flow cytometry. Mutat. Res. 594: 113-119 (2006).[abstract(link is external and opens in a new window)] [PDF]
Smilenov L.B., Hall E.J., Bonner W.M. and Sedelnikova O.A. A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts. Radiat. Prot. Dosimetry 122: 256-259 (2006). [abstract(link is external and opens in a new window)][PDF]
Hu B., Wu L., Han W., Zhang L., Chen S., Xu A., Hei T.K. and Yu Z. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis27:245-251 (2006). [abstract(link is external and opens in a new window)] [PDF]
Amundson S.A., Do K.T., Vinikoor L., Koch-Paiz C.A., Bittner M.L., Trent JM, Meltzer P and Fornace AJ Jr. Stress-specific signatures: Expression profiling of p53 wild-type and null human cells. Oncogene 24:4572-4579 (2005). [abstract(link is external and opens in a new window)] [PDF]
Calaf G.M., Emenaker N.J. and Hei T.K. Effect of retinol on radiation- and estrogen-induced neoplastic transformation of human breast epithelial cells. Oncol Rep 13:1017-1027 (2005). [abstract(link is external and opens in a new window)] [PDF]
Hall E.J., Brenner D.J., Worgul B. and Smilenov L. Genetic susceptibility to radiation. Adv Space Res 35:249-253 (2005). [abstract(link is external and opens in a new window)] [PDF]
Hu B., Han W., Wu L., Feng H., Liu X., Zhang L., Xu A., Hei T.K. and Yu, Z. In situ visualization of DSBs to assess the extranuclear/extracellular effects induced by low-dose alpha-particle irradiation. Radiat Res 164:286-291 (2005). [abstract(link is external and opens in a new window)] [PDF]
Miller, A.C., Beltran, D., Rivas, R., Stewart, M., Merlot, M.J. and Lison, P.B. Radiation- and depleted uranium-induced carcinogenesis studies: Characterization of the carcinogenic process and development of medical countermeasures. The NATO Human Factors and Medicine Panel Research Task Group 099 "Radiation Bioeffects and Countermeasures" meeting, Bethesda, MD. June 21-23, 2005, AFFRI CD 05-2 (2005). [PDF]
Sokolov M.V., Smilenov L.B., Hall E.J., Panyutin I.G., Bonner W.M. and Sedelnikova O.A. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 24:7257-7265 (2005). [abstract(link is external and opens in a new window)] [PDF]
Vives S., Loucas B., Vazquez M., Brenner D.J., Sachs R.K., Hlatky L., Cornforth M. and Arsuaga J. SCHIP: statistics for chromosome interphase positioning based on interchange data. Bioinformatics 21:3181-3182 (2005). [abstract(link is external and opens in a new window)] [PDF]
Worgul B.V., Smilenov L., Brenner D.J., Vazquez M. and Hall E.J. Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes. Adv Space Res 35:254-259 (2005). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Suzuki M., Persaud R., Gillispie J., Randers-Pehrson G. and Hei T.K. Contribution of bystander effects in radiation induced genotoxicity. Acta Medica Nagasakiensia 50:73-77 (2005). [PDF]
Arsuaga J., Greulich-Bode K.M., Vazquez M., Bruckner M., Hahnfeldt P., Brenner D.J., Sachs R. and Hlatky, L. Chromosome spatial clustering inferred from radiogenic aberrations. Int J Radiat Biol 80:507-515 (2004). [abstract(link is external and opens in a new window)] [PDF]
Mitchell C.R., Azizova T.V., Hande M.P., Burak L.E., Tsakok J.M., Khokhryakov V.F., Geard C.R. and Brenner D.J. Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiat Res 162:257-263 (2004). [abstract(link is external and opens in a new window)] [PDF]
Mitchell S.A., Marino S.A., Brenner D.J. and Hall E.J. Bystander effect and adaptive response in C3H 10T(1/2) cells. Int J Radiat Biol 80:465-472 (2004). [abstract(link is external and opens in a new window)] [PDF]
Suzuki M., Zhou H., Hei T.K., Tsuruoka C. and Fujitaka K. Effects of irradiated medium on chromatid aberrations in mammalian cells using double mylar dishes. Biol Sci Space 18:110-111 (2004). [abstract(link is external and opens in a new window)]
Zhao Y., Shao G., Piao C.Q., Berenguer J. and Hei T.K. Down-regulation of Betaig-h3 gene is involved in the tumorigenesis in human bronchial epithelial cells induced by heavy-ion radiation. Radiat Res 162:655-659 (2004). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Randers-Pehrson G., Waldren C.A. and Hei T.K. Radiation-induced bystander effect and adaptive response in mammalian cells. Adv Space Res 34:1368-1372 (2004). [abstract(link is external and opens in a new window)] [PDF]
Amundson SA, Bittner M and Fornace AJ, Jr. Functional genomics as a window on radiation stress signaling. Oncogene 22:5828-5833 (2003). [abstract(link is external and opens in a new window)] [PDF]
Fowler J.F., Ritter M.A., Chappell R.J. and Brenner D.J. What hypofractionated protocols should be tested for prostate cancer? Int. J. Radiat. Oncol. Biol. Phys. 56:1093-1104 (2003). [abstract(link is external and opens in a new window)] [PDF]
Hande M.P., Azizova T.V., Geard C.R., Burak L.E., Mitchell C.R., Khokhryakov V.F., Vasilenko E.K. and Brenner D.J. Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am. J. Hum. Genet. 72:1162-1170 (2003). [abstract(link is external and opens in a new window)] [PDF]
Cornforth M.N., Greulich-Bode K.M., Loucas B.D., Arsuaga J., Vazquez M., Sachs R.K., Bruckner M., Molls M., Hahnfeldt P., Hlatky L. and Brenner D.J. Chromosomes are predominantly located randomly with respect to each other in interphase human cells. J Cell Biol. 159:237-244 (2002). [abstract(link is external and opens in a new window)] [PDF]
Morgan W.F., Hartmann A., Limoli C.L., Nagar S. and Ponnaiya B. Bystander effects in radiation-induced genomic instability. Mutat. Res. 504:91-100 (2002). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Randers-Pehrson G., Suzuki M., Waldren C.A. and Hei T.K. Genotoxic damage in non-irradiated cells: contribution from bystander effect. 13th Symposium on Microdosimetry, Stresa, Italy, May 26-June 1, 2001. Radiat. Prot. Dosim. 99:227-232 (2002). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Suzuki M., Geard C.R. and Hei T.K. Effects of irradiated medium with or without cells on bystander cell responses. Mutat. Res. 499:135-141 (2002). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Xu A., Suzuki K., Randers-Pehrson G., Waldren C.A., Hall E.J. and Hei T.K. The Yin and Yan of bystander versus adaptive response: Lessons from the microbeam studies. Int. Congress Series 1236:241-247 (2002).[abstract(link is external and opens in a new window)]
Amundson S.A., Bittner M., Meltzer P., Trent J. and Fornace A.J., Jr. Biological indicators for the identification of ionizing radiation exposure in humans. Expert Rev Mol Diagn 1:211-219 (2001). [abstract(link is external and opens in a new window)]
Amundson S.A. and Fornace A.J., Jr. Gene expression profiles for monitoring radiation exposure. Radiat Prot Dosimetry 97:11-16 (2001). [abstract(link is external and opens in a new window)]
Milligan J.R., Aguilera J.A., Paglinawan R.A., Ward J.F. and Limoli. C.L. DNA strand break yields after post-high LET irradiation incubation with endonuclease-III and evidence forhydroxyl radical clustering. Int. J. Radiat. Biol. 77:155-164 (2001). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Suzuki M., Randers-Pehrson G., Vannais D., Chen G., Trosko J.E., Waldren C.A., Hei T.K. Radiation risk to low fluences of alpha particles may be greater than we thought. Proc. Natl. Acad. Sci. USA 98:14410-14415 (2001). [abstract(link is external and opens in a new window)] [PDF]
Miller R.C., Marino, S.A., Napoli J., Shah H., Hall, E.J., Geard C.R. and Brenner D.J. Oncogenic transformation in C3H10T½ cells by low-energy neutrons. Int. J. Radiat. Biol. 76:327-334 (2000). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Randers-Pehrson G., Waldren C.A., Vannais D., Hall E.J. and Hei T.K. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97:2099-2104, 2000. [abstract(link is external and opens in a new window)] [PDF]
Miller R.C., Marino S.A., Martin S.G., Komatsu K., Geard C.R., Brenner D.J. and Hall E.J. Neutron-energy-dependent cell survival and oncogenic transformation. J. Radiat. Res. 40:53-59 Suppl (1999). [abstract(link is external and opens in a new window)] [PDF]
Piao C.Q., Willey J.C. and Hei T.K. Alterations of p53 in tumorigenic human bronchial epithelial cells correlate with metastatic potential. Carcinogenesis 20:1529-1533 (1999). [abstract(link is external and opens in a new window)] [PDF]
Wu L.J., Randers-Pehrson G., Xu A., Waldren C.A., Geard C.R., Yu Z. and Hei T.K. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proc Natl Acad Sci USA 96:4959-4964 (1999). [abstract(link is external and opens in a new window)] [PDF]
Hei T.K., Wu L.J., Liu S.X., Vannais D, Waldren C.A. and Randers-Pehrson G. Mutagenic effects of a single and an exact number of a particles in mammalian cells. Proc. Natl. Acad. Sci. USA94:3765-3770 (1997). [abstract(link is external and opens in a new window)] [PDF]
Weaver D.A., Hei T.K., Hukku B., McRaven J.A.M. and Willey J.A. Cytogenetic and molecular genetic analysis of tumorigenic human bronchial epithelial cells induced by radon alpha particles. Carcinogenesis 18:1251-1257 (1997). [abstract(link is external and opens in a new window)]
Biology articles originated by Columbia scientists.
Sun, H., Olsen, T., Zhu, J., Tao, J., Ponnaiya, B., Amundson, S.A., Brenner, D.J., Lin, Q. A microfluidic approach to parallelized transcriptional profiling of single cells. Microfluid NanofluidAccepted. [Journal Site(link is external and opens in a new window)]
Buonanno, M., Randers-Pehrson, G., Smilenov, L.B., Kleiman, N.J., Young, E., Ponnaiya, B., Brenner, D. J., A Mouse Ear Model for Bystander Studies Induced by Microebam Irradiation, Radiation Research 184(2):219-25 (2015) in press
Brenner, D.J., Vazquez, M., Buonanno, M., Amundson, S.A., Bigelow, A.W., Garty, G., Harken, A.D., Hei, T.K., Marino, S.A., Ponnaiya, B., Randers-Pehrson, .G., Xu, Y. Integrated interdisciplinary training in the radiological sciences. Br. J. Radiol. 87: 20130779 (2014). [abstract(link is external and opens in a new window)] [PDF]
Buonanno, M., Garty, G., Grad, M., Gendrel, M., Hobert, O. and Brenner, D.J. Microbeam irradiation of C. elegans nematodes in microfluidic channels. Radiat. Environ. Biophys. 52: 531-537 (2013), PMCID:PMC3809145 [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Zhang, B, Davidson, M.M., Zhou, H., Wang, C., Walker, W.F. and Hei, T.K. Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission. Cancer Res. 73: 6700-6710 (2013), PMCID:PMC3934017 [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Grabham, P., Sharma, P., Bigelow, A. and Geard, C. Distinct mechanisms of the Inhibition of vasculogenesis by different species of charged particles. Vascular Cell 5:16 (2013), PMCID: PMC3856512 [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Ivanov, V.N. and Hei, T.K. A role for TRAIL/TRAIL-R2 in radiation-induced apoptosis and radiation-induced bystander response of human neural stem cells. Apoptosis, 19(3):399-413 (2014). PMCID:PMC3945673 [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Ponnaiya, B., Amundson, S.A., Ghandhi, S.A., Smilenov, L.B., Geard, C.R., Buonanno, M., and Brenner, D.J. Single-cell responses to ionizing radiation. Radiat. Environ. Biophys. 52: 523-530 (2013), PMCID: PMC3812812 [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Bigelow, A.W., Ponnaiya, B., Targoff, K. and Brenner. D.J. UV microspot irradiator at Columbia University. Radiat. Environ. Biophys. 52: 411-417 (2013) PMCID: PMC3723145. [abstract(link is external and opens in a new window)]
Hu, B., Zhu, J., Zhou, H., and Hei, T.K. No significant level of inheritable interchromosomal aberrations in the progeny of bystander primary human fibroblast after alpha particle irradiation. Adv. Space Research 51: 450-457 (2013), PMCID: PMC3596834. [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Zhang, S., Wen, G., Huang, S.X., Wang, J., Tong, J. and Hei, T.K. Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by alpha particles. Int. J. Cancer. 2012 May 30. doi: 10.1002/ijc.27656, PMCID: PMC3467313. [abstract(link is external and opens in a new window)]
Ghandhi, S.A., Sinha, A., Markatou, M., and Amundson, S.A. Time-series clustering of gene expression in irradiated and bystander fibroblasts: an application of FBPA clustering BMC Genomics 12: 2 (2011), PMCID: PMC3022823. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Hei, T.K., Zhou, H., Chai, Y., Ponnaiya, B., and Ivanov, V.N. Radiation induced non-targeted response: mechanism and potential clinical implications. Curr. Mol. Pharmacol. 4: 96-105 (2011), PMCID: PMC3356574. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Ivanov, V.N., Ghandhi, S.A., Zhou, H., Huang, S.X., Chai, Y., Amundson, S.A. and Hei, T.K. Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: a role for NFκB- and STAT3-directed gene expression. Exp.Cell Res. 317: 1548-1566 (2011), PMCID: PMC2860693. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Mezentsev, A., and Amundson, S.A. Global gene expression responses to low- or high-dose radiation in a human three-dimensional tissue model. Radiat. Res. 175: 677-688 (2011), PMCID: PMC3148653. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Hu, B., Shen, B., Su, Y., Geard, C.R. and Balajee, A.S. Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. Int. J. Biochem. Cell Biol. 41: 2413-2421 (2009), PMCID: PMC2784166. [Full Text(link is external and opens in a new window)]
Zhou, H., Hong, M., Chai, Y. and Hei, T.K. Consequences of cytoplasmic irradiation: Studies from microbeam. J. Radiat. Res. 50 Suppl A: A59-65 (2009). [PDF(link is external and opens in a new window)]
Ghandhi, S.A., Sinha, A., Markatou, M., and Amundson, S.A. Time-series clustering of gene expression in irradiated and bystander fibroblasts: an application of FBPA clustering. BMC Genomics 12: 2 (2011), PMCID: PMC3022823. [abstract(link is external and opens in a new window)] [PDF]
Hong, M., Xu, A., Zhou, H., Wu, L., Randers-Pehrson, G., Santella, R.M., Yu, Z. and Hei, T.K. Mechanism of genotoxicity induced by targeted cytoplasmic irradiation. Br J Cancer. 103(8):1263-8 (2010), PMCID: PMC2967061. [abstract(link is external and opens in a new window)] [PDF]
Hei, T.K., Zhou, H., Chai, Y., Ponnaiya, B., and Ivanov, V.N. Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications. Curr. Mol. Pharmacol. 2010 Dec 14, PMCID: PMC3356574. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Ghandhi S.A., Ming L., Ivanov V.N., Hei T.K. and Amundson S.A. Early signaling and gene expression in the radiation bystander response of IMR-90 fibroblasts exposed to 0.5 Gy alpha-particles. BMC Med. Genomics 3: 31 (2010), PMCID: PMC2919438. [abstract(link is external and opens in a new window)] [PDF]
Ivanov V.N., Zhou H., Ghandhi S.A., Karasic T.B., Yaghoubian B., Amundson S.A., Hei T.K. Radiation-induced bystander signaling pathways in human fibroblasts: A role for interleukin-33 in the signal transmission. Cell Signal. 22:1076-1087 (2010). PMCID: PMC2860693 [Available on 2011/7/1]. [abstract(link is external and opens in a new window)] [PDF]
Hei T.K., Zhou H. and Ivanov V.N. The Yin and Yang of low dose radiobiology. Radiation Health Risk Sciences. Springer, Tokyo, pp.135-142 (2009). [abstract(link is external and opens in a new window)] [PDF]
Hei T.K., Ballas L.K., Brenner D.J., Geard C.R. Advances in radiobiological studies using a microbeam. J. Radiat. Res. 50 Suppl. A:A7-A12 (2009), PubMed - indexed for MEDLINE. [abstract(link is external and opens in a new window)] [PDF]
Ghandhi S.A., Yaghoubian B. and Amundson S.A. Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: Synchronous and differential responses. BMC Med Genomics. 1: 63 (2008), PMCID: PMC2627914. [abstract(link is external and opens in a new window)] [PDF]
Hei T.K., Zhou H., Ivanov V.N., Hong M., Lieberman H.B., Brenner D.J., Amundson S.A. and Geard C.R. Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol. 60: 943-950 (2008). PubMed - indexed for MEDLINE. [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Ivanov V.N., Lien Y.C., Davidson M. and Hei T.K. Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res. 68: 2233-2240 (2008), PubMed - indexed for MEDLINE. [abstract(link is external and opens in a new window)] [PDF]
Ivanov V.N., Zhou H. and Hei T.K. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res. 67: 5397-5407 (2007). [abstract(link is external and opens in a new window)] [PDF]
Hei T.K., Radiation-Induced Bystander Effects: Mechanisms and Implication for Low-Dose Radiation Risk Assessment. Radiat. Res. 167: 347-348 (2007).
Hei T.K., Zhou H.Z., Lien Y.C., and Zhao Y.L., Mechanism of radiation carcinogenesis: BigH3, COX-2 and beyond. Int. Congress Series 1299: 114-120 (2007).
Ivanov V.N., Zhou H., and Hei T.K. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates trail-mediated apoptosis of human melanoma cells. Cancer Res. 67: 5397-5407 (2007).[abstract(link is external and opens in a new window)] [PDF]
Ponnaiya B, Jenkins-Baker G., Randers-Pherson G., and Geard CR. Quantifying a bystander response following microbeam irradiation using single-cell RT-PCR analyses. Exp. Hematol.35(4 Suppl 1): 64-68 (2007).[abstract(link is external and opens in a new window)] [PDF]
Calaf G.M., Roy D., Hei T.K. Growth factor biomarkers associated with estrogen- and radiation-induced breast cancer progression. Int. J. Oncol. 28:87-93 (2006). [PDF]
Hei T.K. Cyclooxygenase-2 as a signaling molecule in radiation induced bystander effect. Mol. Carcinogenesis 45:455-460 (2006). [abstract(link is external and opens in a new window)] [PDF]
Belyakov O.V., Mitchell S.A., Parikh D., Randers-Pehrson G., Marino S.A., Amundson S.A., Geard C.R. and Brenner D.J. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc Natl Acad Sci U S A 102:14203-14208 (2005). [abstract(link is external and opens in a new window)] [PDF]
Calaf G.M., Roy D. and Hei T.K. Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation Histochem. Cell Biol. 124:261-274 (2005). [PDF]
Persaud R., Zhou H., Baker S.E., Hei T.K. and Hall E.J. Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res65:9876-82 (2005). [abstract(link is external and opens in a new window)] [PDF]
Smilenov L.B., Lieberman H.B., Mitchell S.A., Baker R.A., Hopkins K.M. and Hall E.J. Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics. Cancer Res 65:933-938 (2005). [abstract(link is external and opens in a new window)] [PDF]
Zhou H., Ivanov V.N., Gillespie J., Geard C.R., Amundson S.A., Brenner D.J., Yu Z., Lieberman H.B., and Hei T.K. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci U S A, 102:14641-14646 (2005). [abstract(link is external and opens in a new window)] [PDF]
Zhu A., Zhou H., Leloup C., Marino S.A., Geard C.R., Hei T.K. and Lieberman H.B. Differential impact of mouse Rad9 deletion on ionizing radiation-induced bystander effects. Radiat Res164:655-661 (2005). [abstract(link is external and opens in a new window)] [PDF]
Balajee A.S. and Geard C.R. Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks. Exp. Cell. Res. 300:320-334 (2004). [abstract(link is external and opens in a new window)] [PDF]
Balajee A.S., Ponnaiya B., Baskar R. and Geard C.R. Induction of replication protein a in bystander cells. Radiat. Res. 162:677-686 (2004). [abstract(link is external and opens in a new window)] [PDF]
Brenner D.J. Comments on "Chromosome intrachanges and interchanges detected by multicolor banding in lymphocytes: Searching for clastogen signatures in the human genome" by Johannes et al. (Radiat. Res. 161:540-548, 2004). Radiat Res 162:600; author reply 601 (2004). [PDF]
Calaf G.M. and Hei T.K. Ionizing radiation induces alterations in cellular proliferation and c-myc, c-jun and c-fos protein expression in breast epithelial cells. Int J Oncol 25:1859-1866 (2004). [abstract(link is external and opens in a new window)]
Geard C.R. and Ponnaiya B. Chromosomal changes and cell cycle checkpoints in Mammalian cells. Methods Mol. Biol. 241:315-328 (2004).
Hei T.K., Persaud R., Zhou H. and Suzuki M. Genotoxicity in the eyes of bystander cells. Mutat. Res. 568:111-120 (2004). [abstract(link is external and opens in a new window)] [PDF]
Mitchell S.A., Randers-Pehrson G., Brenner D.J. and Hall E.J. The Bystander Response in C3H 10T(1/2) Cells: The Influence of Cell-to-Cell Contact. Radiat. Res. 161:397-401 (2004).[abstract(link is external and opens in a new window)] [PDF]
Ponnaiya B, Jenkins-Baker G, Bigelow A, Marino S and Geard CR. Detection of chromosomal instability in alpha-irradiated and bystander human fibroblasts. Mutat. Res. 568:41-8 (2004). [abstract(link is external and opens in a new window)] [PDF]
Ponnaiya G, Jenkins-Baker G, Brenner DJ, Hall EJ, Randers-Pherson G and Geard CR. Biological responses in known bystander cells, relative to known microbeam irradiated cells. Radiat. Res.162:426-432 (2004). [abstract(link is external and opens in a new window)] [PDF]
Suzuki M., Zhou H., Geard C.R. and Hei T.K. Effect of medium on chromatin damage in bystander mammalian cells. Radiat. Res. 162:264-269 (2004). [abstract(link is external and opens in a new window)] [PDF]
Hall E.J. The bystander effect. Health Physics 85:31-35 (2003). [abstract(link is external and opens in a new window)] [PDF]
Hall E.J. and Hei T.K. Genomic instability and bystander effects induced by high-LET radiation.Oncogene 22:7034-7042 (2003).[abstract(link is external and opens in a new window)] [PDF]
Suzuki M., Zhou H., Hei T.K., Tsuruoka C. and Fujitaka K. Induction of a bystander chromosomal damage of He-ion microbeams in mammalian cells. Biol. Sci. Space 17:251-252 (2003). [abstract(link is external and opens in a new window)]
Zhou H., Randers-Pehrson G., Geard C.R., Brenner D.J., Hall E.J. and Hei T.K. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research 160:512-516 (2003). [abstract(link is external and opens in a new window)] [PDF]
Brenner D.J., Sawant S.G., Hande M.P., Miller R.C., Elliston C.D., Fu Z., Randers-Pehrson G., and Marino S.A. Routine screening mammography: how important is the radiation-risk side of the benefit-risk equation? Int J Radiat Biol. 78:1065-1067 (2002). [abstract(link is external and opens in a new window)] [PDF]
Geard C.R., Ponnaiya B., Jenkins-Baker G., Hei T.K., Brenner D.J., Hall E.J. and Randers-Pehrson G. Microbeam mediated cellular effects: Observations and implications for low dose radiation risk assessment. In Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development (Tanaka, K., Takabataka, T., Fujikawa, K., Matsumoto, T. and Sato, F., Eds.), Institute for Environmental Science, Japan, p. 82-88 (2002).
Geard C.R., Jenkins-Baker G., Marino S.A. and Ponnaiya B. Novel approaches with track segment alpha particles and cell co-cultures in studies of Bystander Effects. Radiat. Prot. Dosim. 99:233-236 (2002). [abstract(link is external and opens in a new window)]
Sawant S.G., Zheng W., Hopkins K.M., Randers-Pehrson G., Lieberman H.B. and Hall E.J. The radiation-induced bystander effect for clonogenic survival. Radiat. Res. 157:361-364 (2002). [abstract(link is external and opens in a new window)] [PDF]
Balajee A.S. and Geard C.R. Chromatin bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res.29:1341-1351 (2001). [abstract(link is external and opens in a new window)] [PDF]
Calaf G.M. and Hei T.K. Oncoprotein expression in human breast epithelial cells transformed by high LET radiation. Int. J. Radiat. Biol. 77:31-40 (2001). [abstract(link is external and opens in a new window)] [PDF]
Hall E.J. Genomic instability, bystander effect, cytoplasmic irradiation and other phenomena that may achieve fame without fortune. Phys. Med. 17 Suppl 1:21-25 (2001). [abstract(link is external and opens in a new window)]
Hei T.K., Zhao Y.L., Roy D., Piao C.Q., Calaf G. and Hall E.J. Molecular alterations in tumorigenic human bronchial and breast epithelial cells transformed by ionizing radiation. Adv. Space Res.27:411-419 (2001). [abstract(link is external and opens in a new window)] [PDF]
Piao C.Q. and Hei T.K. Gene amplification and microsatellite instability induced tumorigenic human bronchial epithelial cells by alpha particles and heavy ions. Radiat. Res. 155:263-267 (2001). [abstract(link is external and opens in a new window)] [PDF]
Roy D., Calaf G. and Hei T.K. Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells. Carcinogenesis Oct;22(10):1685-1692 (2001). [abstract(link is external and opens in a new window)] [PDF]
Roy D., Calaf G. and Hei T.K. Profiling of differentially expressed genes induced by high linear energy transfer radiation in breast epithelial cells. Mol. Carcinog. Aug;31(4):192-203 (2001). [abstract(link is external and opens in a new window)] [PDF]
Sawant S.G., Randers-Pehrson G., Metting, N. and Hall E.J. Adaptive response and the bystander effect induced by radiation in C3H 10T(1/2) cells in culture. Radiat. Res. 156:177-180 (2001). [abstract(link is external and opens in a new window)] [PDF]
Sawant S.G., Randers-Pehrson G., Geard C.R., Brenner D.J. and Hall E.J. The bystander effect in radiation oncogenesis I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155:397-401 (2001). [abstract(link is external and opens in a new window)] [PDF]
Zhao Y.L., Piao C.Q., Hall E.J. and Hei T.K. Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. Radiat. Res. 155:230-234 (2001). [abstract(link is external and opens in a new window)] [PDF]
Calaf G.M. and Hei T.K. Establishment of a radiation- and estrogen-induced breast cancer model. Carcinogenesis 21:769-776 (2000). [abstract(link is external and opens in a new window)] [PDF]
Geard C.R., Randers-Pehrson G., Marino S.A., Jenkins-Baker G., Hei T.K., Hall E.J. and Brenner D.J. Intra- and inter-cellular responses following cell-site specific microbeam irradiation. Radiat. Res. 153:233 (2000). [PDF]
Hei T.K., Roy D., Piao C.Q., Calaf G. and Hall E.J. Genomic instability in human epithelial cells transformed by high LET radiation. In: Proceedings of Radiation Research (Moriarty M., Mothersill C., Seymour C., Edington M., Ward J.F. and Fry R.J.M., Eds.), pp. 560-563, Allen Press, Lawrence, KS (2000).
Hei T.K., Zhou H.N., Wu L.X., Randers-Pehrson G., Waldren C. and Geard C.R. Radiation induced genotoxic damage: From cytoplasm to nucleus and the bystander phenomenon. In: Free Radicals in Chemistry, Biology and Medicine (Yoshikawa T., Toyokuni S., Naito Y. and Yamamoto Y., Eds.), pp. 241-247, OICA International Press, London (2000).
Miller R.C., Sawant S.G., Randers-Pehrson G., Marino S.A., Geard C.R., Hall E.J. and Brenner D.J. Single alpha-particle traversals and tumor promoters. Radiation Research 153:227 (2000). [PDF]
Zhou H., Randers-Pehrson G. and Hei T.K. Studies of bystander mutagenic response using a charged particle microbeam. Radiation Research 153:234-235 (2000). [PDF]
Miller R.C., Randers-Pehrson G., Geard C.R., Hall E.J., and Brenner D.J. The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc. Nat. Acad. Sci. USA 96:19-22 (1999). [abstract(link is external and opens in a new window)] [PDF]
Miller R.C., Martin S.G., Geard C.R., Marino S.A., Randers-Pehrson G., Brenner D.J. and Hall E.J. High LET-induced oncogenic transformation. In: Risk Evaluation of Cosmic-ray Exposure in Long-term Manned Space Mission (Fujitaka, et al., Eds.) pp. 121-126, Kondasha Scientific Ltd., Tokyo, Japan (1999).
Zhou H., Zhu L.X., Li K. and Hei T.K. Radon, tobacco-specific nitrosamine and mutagenesis in mammalian cells. Mutat. Res. 430:145-153 (1999). [abstract(link is external and opens in a new window)] [PDF]
Hei T.K., Piao C.Q., Wu L.X., Willey J.C. and Hall E.J. Genomic instability and tumorigenesis induction in immortalized human bronchial cells by heavy ions. Adv. Space Res. 22:1699-1707 (1998). [abstract(link is external and opens in a new window)] [PDF]
Miller R.C., Martin S.G., Hanson W.R., Marino S.A. and Hall E.J. Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions. Adv. Space Res. 22:1719-1723 (1998). [abstract(link is external and opens in a new window)] [PDF]
Geard C.R., Randers-Pehrson G., Hei T.K., Jenkins G.J., Miller R.C., Wu L.J., Brenner D.J. and Hall E.J. Microbeam mediated cellular effects: Single alpha particle induced chromosomal damage, cell cycle delay, mutation and oncogenic transformation. In: Microdosimetry, An interdisciplinary approach (Goodhead D.T., O’Neill P. and Menzel H.G., Eds.), pp327-330 (1997).
Physics articles involving outside scientists.
Fuks, E., Horowitz, Y.S., Horowitz, A., Oster, L., Marino, S., Rainer, M., Rosenfeld, A. and Datz, H. Thermoluminescence solid state nanodosimetry – the peak 5a/5 dosimeter. Radiat. Prot. Dosim. 143: 416-426 (2011), PMCID: PMC3108276. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Horowitz, Y., Fuks, E., Datz, H., Oster, L., Livingstone, J. and Rosenfeld, A. Mysteries of LiF TLD response following high ionisation density irradiation: nanodosimetry and track structure theory, dose response and glow curve shapes. Radiat. Prot. Dosimetry. 145: 356-372 (2011), PMCID: PMC3145381. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Horowitz, Y.S., Horowitz, A., Oster, L., Marino, S., Datz, H. and Margaliot, M. Investigation of the Ionisation Density of the Glow Curve Characteristics of LiF:Mg,Ti. Radiat. Prot. Dosim. 131: 406-413 (2008), PMCID: PMC3480322. [Full Text(link is external and opens in a new window)]
Shuryak I., Ullrich R.L., Sachs R.K. and Brenner D.J. The balance between initiation and promotion in radiation-induced murine carcinogenesis. Radiat. Res. 174:357-366 (2010), PMCID: PMC3570813. [abstract(link is external and opens in a new window)] [PDF]
Aprile E., Baudis L., Choi B., Giboni K.L., Lim K., Manalaysay A., Monzani M.E., Plante G., Santorelli R. and Yamashita M. New measurement of the relative scintillation efficiency of xenon nuclear recoils below 10 keV. Phys. Rev. C 79: 045807 (2009). [PDF]
Bigelow A.W., Garty G., Funayama T., Randers-Pehrson G., Brenner D.J. and Geard C. Expanding the Question-answering Potential of Single-cell Microbeams at RARAF, USA. J. Radiat. Res. 50: Suppl., A21-A28, 2009. PMCID: PMC2924733. [abstract(link is external and opens in a new window)] [PDF]
Brenner D.J., Elliston C.D., Hall E.J. and Paganetti H. Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator. Phys. Med. Biol. 54:6065-6078 (2009). [abstract(link is external and opens in a new window)] [PDF]
Shuryak I., Hahnfeldt P., Hlatky L., Sachs R.K. and Brenner D.J. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat. Environ. Biophys. 48:263-274 (2009), PMCID: PMC2714893. [abstract(link is external and opens in a new window)] [PDF]
Shuryak I., Hahnfeldt P., Hlatky L., Sachs R.K. and Brenner D.J. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat. Environ. Biophys. 48:275-286 (2009), PMCID: PMC2714894. [abstract(link is external and opens in a new window)] [PDF]
Zeitlin, C.J., Maurer, R.H., Roth, D.R., Goldsten, J.O., Grey, M.P. Development and evaluation of the combined ion and neutron spectrometer (CINS). Nucl. Inst. Methods B 267: 125-138 (2009). [PDF]
Shuryak I., Sachs R.K. and Brenner D.J. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat Res. 168: 741-749 (2007).[abstract(link is external and opens in a new window)] [PDF]
Nikolaev A., Oks E.M., Savkin K., Yushkov G.Yu., Brenner, D.J. Johnson G., Randers-Pehrson G., Brown I.G. and MacGill R.A. Surface resistivity tailoring of ceramic insulators for an ion microprobe application. Surf. Coat. Tech 201: 8120-8122 (2007).[PDF]
Sykora G.J., Akselrod M.S., Salasky M., Marino S.A., Novel Al2O3:C, Mg Fluorescent Nuclear Track Detectors for Passive Neutron Dosimetry, Radiat. Prot. Dosim. 126: 278-283 (2007).[abstract(link is external and opens in a new window)] [PDF]
Shuryak I., Sachs R.K., Hlatky L., Little M.P., Hahnfeldt P., Brenner D.J., Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst. 98:1794-1806 (2006).[abstract(link is external and opens in a new window)] [PDF]
Brenner D.J., Sachs R.K., Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach. Radiat. Environ. Biophys. 44: 253-256 (2006).[abstract(link is external and opens in a new window)] [PDF]
Maurer, R.H., Roth, D.R., Kinnison, J.D., Haggerty, D.K. and Goldsten, J.O. The NSBRI/APL Neutron Energy Spectrometer. Johns Hopkins APL Technical Digest 27: 56-65 (2006).[PDF]
Aprile E., Giboni K.L., Majewski P., Ni K., Yamashita M., Hasty R., Manzur A. and McKinsey D.N. Scitillation response of liquid Xenon to low energy nuclear recoils. Phys. Rev. D 72:072006 (2005). [PDF]
Maurer R.H., Zeitlin C.J., Haggerty D.K., Roth D.R. and Goldsten J.O. Compact ion and neutron spectrometer (CINS) for space application. 2005 IEEE Nuclear Science Symposium Conference Record, N14-48, pp. 428-432, Puerto Rico, 23-29 October 2005.[PDF]
Sachs R.K. and Brenner D.J. Solid tumor risks after high doses of ionizing radiation. Proc. Natl. Acad. Sci. USA 102:13040-13045 (2005). [abstract(link is external and opens in a new window)] [PDF]
Brenner D.J. and Sachs R.K. Domestic radon risks may be dominated by bystander effects – but the risks are unlikely to be greater than we thought. Health Phys. 85:103-108 (2003). [abstract(link is external and opens in a new window)] [PDF]
Maurer RH, Roth DR, Kinnison JD, Goldsten JO, Gold RE and Fainchtein R. MArs Neutron Energy Spectrometer (MANES): An instrument for the Mars 2003 Lander. Acta Astronaut. 52:405-410 (2003). [abstract(link is external and opens in a new window)] [PDF]
Horowitz Y.S., Oster L., Biderman S. and Einav Y. Localized transitions in the thermoluminescence of LiF:Mg,Ti:potential for nanoscale dosimetry. J. Phys. D. Appl. Phys.36:446-459 (2003). [abstract(link is external and opens in a new window)] [PDF]
Kinnison J.D., Maurer R.H., Roth D.R. and Haight R. C. High energy neutron spectroscopy with thick silicon detectors. Radiat. Res. 159:154-160 (2003). [abstract(link is external and opens in a new window)] [PDF]
Brenner D.J. and Sachs R.K. Do low dose-rate bystander effects influence domestic radon risks? Int. J. Radiat. Biol. 78:593-604 (2002). [abstract(link is external and opens in a new window)] [PDF]
Brenner D.J., Little J.B. and Sachs R.K. The bystander effect in radiation oncogenesis II. A quantitative model. Radiat. Res. 155:402-408 (2001). [abstract(link is external and opens in a new window)] [PDF]
Maurer R.H., Kinnison J.D., Roth D.R. and Goldsten J.O. Neutron spectroscopy on the international space station, AIAA Conference on International Space Station Utilization, Cape Canaveral, FL, 16 October, 2001. Proceedings published on CD ROM (AIAA paper 2001-5059).
Ponomarev A.L., Cucinotta F.A., Sachs R.K. and Brenner D.J. Monte Carlo predictions of DNA fragment-size distributions for large sizes after HZE particle irradiation. Phys. Med. 17 Suppl 1:153-156 (2001). [abstract(link is external and opens in a new window)]
Ponomarev A.L., Cucinotta F.A., Sachs R.K., Brenner D.J. and Peterson L.E. Extrapolation of the DNA fragment-size distribution after high-dose irradiation to predict effects at low doses.Radiat. Res. 156:594-597 (2001). [abstract(link is external and opens in a new window)] [PDF]
Hong J., Craig W.W. and Hailey C.J. Laboratory tests on neutron shields for gamma-ray detectors in space. Nucl. Instrum. Methods Phys. Res. A 452:192-204 (2000). [PDF]
Maurer R.H., Roth D.R., Fainchtein R., Goldsten J.O. and Kinnison, J.D. Portable real time neutron spectrometry II, Proceedings of the International Space Station Conference, Albuquerque, NM, January 30-February 3, 2000.
Ponomarev A.L., Brenner D.J., Hlatky L.R., and Sachs R.K. A polymer, random walk model for the size-distribution of large DNA fragments after high linear energy transfer radiation. Radiat. Environ. Biophys. 39:111-120 (2000). [abstract(link is external and opens in a new window)] [PDF]
Le B.Q., Maurer R.H., Nhan E. and Lew A. Design, fabrication, and qualification of chip-on-board technology for space electronics. Int. J. Microcircuits Electron. Packag. (USA) 22:104-114 (1999).
Hong J., Hailey C.J. and Craig W.W. Development of neutron shields in gamma-ray detectors. In: Proceedings of the SPIE, 3445 (Siegmund O. and Gunmin M., Eds.), pp. 121-131 (1998). [PDF]
Obelic B., Srdoc D., Djuric P.M. and Marino S.A. The frequency distribution of the number of ion pairs in irradiated tissue. Radiat. Res. 149:411-415 (1998). [abstract(link is external and opens in a new window)]
Azziz N., Ranogajec-Komor M., Marino S.A., Klemic G.A. and Osvay M. Fast neutron detection using aluminum oxide TLDs. In Proc. of the IRPA Regional Symposium on Radiation Protection in Neighboring Countries of Central Europe (J. Sabol, Ed.) pp. 495-497, Prague, Czech Republic (1997).
Physics articles originated by Columbia scientists.
England, M. J., Bigelow, A. W., Merchant, M.J., Velliou, E., Welch, D., Brenner, D.J., and Kirkby, K.J. "Automated microbeam observation environment for biological analysis—Custom portable environmental control applied to a vertical microbeam system." Sensors and Actuators B: Chemical 239:1134-1143 (2017). [Journal Link(link is external and opens in a new window)]
Xu Yanping, Randers-Pehrson G, Turner HC, Marino SA, Geard CR, Brenner DJ and Garty G., Accelerator-based biological irradiation facility simulating neutron exposure from an improvised nuclear device. Radiation Research, in press.
Xu Y, Randers-Pehrson G, Marino SA, Garty G, Harken A and Brenner DJ. Broad energy range neutron spectroscopy using a liquid scintillator and a proportional counter: Application to a neutron spectrum similar to that from an improvised nuclear device. Nuclear Instruments & Methods in Physics Research Section A-Accelerators Spectrometers Detectors and Associated Equipment 794:234-239 (2015). [Journal(link is external and opens in a new window)]
Garty G, Ehsan MU, Buonanno M, Yang Z, Sweedler JV and Brenner DJ. Microbeam Coupled Capillary Electrophoresis. Radiat. Prot. Dosim. epub. ahead of print April 2015. [Journal(link is external and opens in a new window)]
Welch, D. and Christen, J.B. Real-time feedback control of pH within microfluidics using integrated sensing and actuation. Lab Chip, 14:1191-1197 (2014) [Journal(link is external and opens in a new window)]
Grad, M., Young, E.F. Smilenov, L., Brenner, D.J. and Attinger, D. A simple add-on microfluidic appliance for accurately sorting small populations of cells with high fidelity. J. Micromech. Microeng. 23: 117003 (2013), PMCID: PMC3883503. [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Bigelow, A.W., Ponnaiya, B., Targoff, K. and Brenner. D.J. UV microspot irradiator at Columbia University. Radiat. Environ. Biophys. 52: 411-417 (2013) PMCID:PMC3723145 [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Grad, M. “The Integration of Active Silicon Components into Polymer Microfluidic Devices” (Columbia University Ph. D. Thesis), 2013.
Grad, M., Bigelow, A.W., Garty, G., Attinger, D. and Brenner D.J. Optofluidic cell manipulation for a biological microbeam. Rev. Sci. Instrum. 84: 014301 (2013), PMCID: PMC3562345. [abstract(link is external and opens in a new window)]
Grad, M., Harken, A., Randers-Pehrson, G., Attinger, D. and Brenner, D.J. An ultra-thin Schottky diode as a transmission particle detector for biological microbeams. J. Instrum. 7: P12001 (2012) PMCID:PMC3776448. [PMC(link is external and opens in a new window)] [Journal(link is external and opens in a new window)]
Lyulko, O.V. "Simultaneous Immersion Mirau Interferometry" (Columbia University Ph.D. thesis) (2012)
Lyulko, O.V., Randers-Pehrson, G. and Brenner, D.J. Simultaneous immersion Mirau interferometry. Rev. Sci. Instrum. 84: 053701 (2013), PMCID: PMC3656945. [abstract(link is external and opens in a new window)]
Xu, J. ‘’Dynamics of Drops and Bubbles in Micro Geometries’’ (Columbia University Ph.D. Thesis), CreateSpace publishers, Scotts Valley, CA USA, 2010, ISBN: 1453702709.
Xu, Y., Turner, H.C., Garty, G. and Brenner, D. A rapid, quantitative method to characterize the human lymphocyte concentration for automated high-throughput radiation biodosimetry.Biomed. Eng. Res. 2: 16-19 (2013), PMCID: PMC3683596. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Zhu, J., Shang, J., Brenner, D. and Lin, Q. An elastomeric polymer microchip for mechanically tunable cell trapping. Proceedings of the 2013 IEEE Int. Conference on Micro Electro Mechanical Systems (MEMS '13), Taipei, Taiwan, January 20-24, 2013, pp. 945-948.
Zhu, J. Shang, J., Jia, Y., Liu, K., Brenner, D. and Lin, Q. Physical modulation based cell manipulation in microfluidic devices. In the Proceedings of the 2013 IEEE Int. Conference on Nano/Micro Engineered and Molecular Systems (NEMS’13, Suzhou, China), April 7-10, 2013, pp. 1226-1229.
Brenner, D.J. 2012 Failla Award Lecture: Exploring two two-edged swords. Radiat Res. 178: 7-16 (2012), PMCID: PMC3573181. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Shuryak, I. and Brenner, D.J. Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death. Radiat. Res. 178: 17-24 (2012), PMCID: PMC3580191.
Xu, Y., Garty G., Marino, S.A., Massey, T.N., Randers-Pehrson, G., Johnson, G.W. and Brenner, D.J. Novel neutron sources at the Radiological Research Accelerator Facility. J. Instrum. 7: C03031 (2012), PMCID: PMC3337765. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Bigelow, A.W., Randers-Pehrson, G., Garty, G., Geard, C. R, Xu, Y., Harken, A.D., Johnson, G.W. and Brenner, D.J. Ion, X-ray, UV and neutron microbeam systems for cell irradiation. AIP Conf. Proc. 1336: 351-355 (2011), PMCID: PMC3570827. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Harken, A.D., Randers-Pehrson, G., Johnson, G.W. and Brenner, D.J. The Columbia University proton-induced soft x-ray microbeam. Nucl. Inst. Meth. B 269: 1992-1996 (2011), PMCID: PMC3146766. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Marino, S.A., Johnson, G.W., Schiff, P.B. and Brenner, D.J. Modification of shirt buttons for retrospective radiation dosimetry after a radiological event. Health Phys. 100: 542-547 (2011), PMCID: PMC3079536. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Xu, Y., Randers-Pehrson, G., Marino, S.A., Bigelow, A.W., Akselrod, M.S., Sykora, J.G. and Brenner, D.J. An accelerator-based neutron microbeam system for studies of radiation effects. Radiat. Prot. Dosimetry. 145: 373-376 (2011), PMCID: PMC3145382. [abstract(link is external and opens in a new window)] [Full Text(link is external and opens in a new window)]
Garty G, Grad M, Jones BK, Xu Y, Xu J, Randers-Pehrson G, Attinger D, Brenner DJ. Design of a novel flow-and-shoot microbeam. Radiat. Prot. Dosimetry 143:344-348 (2011), PMCID: PMC3108275. [abstract(link is external and opens in a new window)] [PDF]
Xu Y, Randers-Pehrson G, Marino SA, Bigelow AW, Akselrod MS, Sykora JG, Brenner DJ. An accelerator-based neutron microbeam system for studies of radiation effects. Radiat. Prot. Dosimetry 2010 Dec 3. PMCID: PMC3145382. [abstract(link is external and opens in a new window)] [PDF]
Lyulko O.V., Randers-Pehrson G. and Brenner D.J. Immersion Mirau interferometry for label-free live cell imaging in an epi-illumination geometry. Proc. SPIE. 7568:756825 (2010). [abstract(link is external and opens in a new window)] [PDF]
Grad, M., Smilenov, L., Brenner, D. and Attinger, D. Characterization of switching time and cell stress in a gravity-driven microfluidic cell sorter based on hydrodynamic switching. Proceedings of ASME 8th International Conference on Nanochannels, Microchannels, and Minichannels, 2010, pp. 907-913.
Brenner D.J. Extrapolating radiation-induced cancer risks from low doses to very low doses. Health Phys. 97:505-509 (2009), PubMed - indexed for MEDLINE. [abstract(link is external and opens in a new window)] [PDF]
Randers-Pehrson G, Johnson GW, Marino SA, Xu Y, Dymnikov AD, Brenner DJ. The Columbia University sub-micron charged particle beam. Nucl. Instrum. Methods Phys. Res. A 609:294-299 (2009). PMCID: PMC2778032 [abstract(link is external and opens in a new window)] [PDF]
Bigelow A.W., Geard C.R., Randers-Pehrson G. and Brenner D.J. Microbeam-integrated multiphoton imaging system. Rev. Sci. Instrum. 79:123707 (2008), PMCID: PMC2736647. [abstract(link is external and opens in a new window)] [PDF]
Bigelow A.W., Brenner D.J., Garty G. and Randers-Pehrson G. Single-particle/single-cell ion microbeams as probes of biological mechanisms. IEEE Trans. Plasma Sci. 36:1424-1431 (2008). [PDF]
Xu, J. and Attinger, D. Drop on demand in a microfluidic chip. J. Micromech. Microeng. 18: 065020 (2008).
Xu, J. and Attinger, D. Dispensing single fluid particles on demand in a microfluidic chip. In Proceedings of µTAS 2008, Locascio, L., Gaitan, M., Paegel, B.M. Ross, D,J, and Vreeland, W.N. (Eds.), 2008, Stoughton, WI, pp. 1378-1380.
Garty G., Ross G.J., Bigelow A., Randers-Pehrson G. and Brenner D.J. Testing the stand-alone microbeam at Columbia University. Radiat. Prot. Dosim. 122:292-296 (2006). [abstract(link is external and opens in a new window)] [PDF]
Bigelow A., Ross G., Randers-Pehrson G. and Brenner DJ. The Columbia University Microbeam II endstation for cell imaging and irradiation. Nucl Instr Meth B 231:202-206 (2005). [PDF]
Bigelow, A.W., Randers-Pehrson, G., Kelly, R.P. and Brenner, D.J. Laser Ion Source for Columbia University’s Microbeam. Nucl. Instr. Meth. B 241: 874-879 (2005). [PDF]
Garty G., Randers-Pehrson G. and Brenner D.J. Development of a secondary-electron ion-microscope for microbeam diagnostics. Nucl Instr Meth B 231:60-64 (2005). [PDF]
Garty G., Ross G.J., Bigelow A., Randers-Pehrson G. and Brenner D.J. A microbeam irradiator without an accelerator. Nucl. Instrum. Meth. B 241:392-396 (2005). [PDF]
Ross G.J., Bigelow,A.W., Randers-Pehrson G., Peng C.C. and Brenner D.J. Phase-based cell imaging techniques for microbeam irradiations. Nucl Instr Meth B241: 387-391 (2005). [PDF]
Ross G., Garty G., Randers-Pehrson G. and Brenner D.J. A single-particle/single-cell microbeam based on an isotopic alpha source. Nucl Instr Meth B 231:207-211 (2005). [PDF]
Bigelow A.W., Randers-Pehrson G. and Brenner D.J. Proposed laser ion source for the Columbia University microbeam. Nucl. Instr. Meth. B 210:65-69 (2003). [PDF]
Bigelow A.W., Randers-Pehrson G. and Brenner D.J. Laser ion source development for the Columbia University microbeam. Rev. Sci. Instrum. 73:770-772 (2002). [abstract(link is external and opens in a new window)] [PDF]
Randers-Pehrson G. Microbeams, microdosimetry and specific dose. Radiat. Prot. Dosim.99:471-472 (2002). [abstract(link is external and opens in a new window)]
Brenner D.J. and Elliston C.D. The potential impact of the bystander effect on radiation risks in a Mars mission. Radiat. Res. 156:612-617 (2001) [abstract(link is external and opens in a new window)] [PDF]
Randers-Pehrson G., Geard C.R., Johnson G., Elliston C.D. and Brenner D.J. The Columbia University single-ion microbeam. Radiat. Res. 156:210-214 (2001). [abstract(link is external and opens in a new window)] [PDF]
Dymnikov A.D., Brenner D.J., Johnson G.W. and Randers-Pehrson G. Electrostatic lens design for the Columbia microbeam. Radiation Research 153:236-237 (2000). [PDF]
Dymnikov A.D., Brenner D.J., Johnson G. and Randers-Pehrson G. Theoretical study of short electrostatic lens for the Columbia ion microprobe. Rev. Sci. Instr. 71:1646-1650 (2000). [abstract(link is external and opens in a new window)] [PDF]
Randers-Pehrson G., Geard C.R., Johnson G.W. and Brenner D.J. Technical characteristics of the Columbia University single-ion microbeam. Radiation Research 153:221-223 (2000). [PDF]
Randers-Pehrson G. and Brenner D.J. A practical target system for accelerator-based BNCT which may effectively double the dose rate. Med. Phys. 28:894-896 (1998). [abstract(link is external and opens in a new window)].
Published proceedings from workshops sponsored by RARAF.
Proceedings of the 8th international workshop: Microbeam probes of cellular radiation response. J. Radiat. Res. 50:suppl. A81-A125 (2009) [PDF 5.82 MB]
Proceedings of the 7th international workshop: Microbeam probes of cellular radiation response. Radiat. Res. 166:652-689 (2006) [PDF 323 KB]
Proceedings of the 6th international workshop/12th L. H. Gray workshop: Microbeam probes of cellular radiation response. Radiat. Res. 161:87-119 (2004). [PDF 293 KB]
Proceedings of the 5th international workshop: Microbeam probes of cellular radiation response. Radiat. Res. 158:365-385 (2002). [PDF 190 KB]
Brenner D.J. and Hall E.J. Microbeams: A potent mix of physics and biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation Response. Radiat Prot Dosimetry. 99:283-6 (2002). [abstract(link is external and opens in a new window)]
Extended Abstracts, Probing individual cells: Applications to signaling, structure and function. Radiat. Res. 156:434-445 (2001). [PDF 900 KB]
Proceedings of the 4th international workshop: Microbeam probes of cellular radiation response. Radiat. Res. 153:220-238 (2000). [PDF 226 KB]