Publications

Wang, Q., Rodrigues, M. A., Repin, M., Pampou, S., Beaton-Green, L. A., Perrier, J., Garty, G., Brenner, D. J., Turner, H. C. & Wilkins, R. C. Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay. Radiat Res 191, 342-351, doi:10.1667/RR15243.1 (2019). [Radiation Research]

Repin, M., Pampou, S., Garty, G. & Brenner, D. J. RABiT-II: A Fully-Automated Micronucleus Assay System with Shortened Time to Result. Radiat Res 191, 232-236, doi:10.1667/RR15215.1 (2019). [Radiation Research]

Lee, Y., Pujol Canadell, M., Shuryak, I., Perrier, J. R., Taveras, M., Patel, P., Koller, A., Smilenov, L. B., Brenner, D. J., Chen, E. I. & Turner, H. C. Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model. Sci Rep 8, 13557, doi:10.1038/s41598-018-31740-8 (2018). [Scientific Reports]

Ghandhi, S. A., Turner, H. C., Shuryak, I., Dugan, G. O., Bourland, J. D., Olson, J. D., Tooze, J. A., Morton, S. R., Batinic-Haberle, I., Cline, J. M. & Amundson, S. A. Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. PLoS One 13, e0191402, doi:10.1371/journal.pone.0191402 (2018). [PLoS One]

Repin, M., Pampou, S., Karan, C., Brenner, D. J. & Garty, G. RABiT-II: Implementation of a High-Throughput Micronucleus Biodosimetry Assay on Commercial Biotech Robotic Systems. Radiat Res 187, 492-498, doi:10.1667/RR011CC.1 (2017). [Radiation Research]

Garty, G., Xu, Y., Elliston, C., Marino, S. A., Randers-Pehrson, G. & Brenner, D. J. Mice and the A-Bomb: Irradiation Systems for Realistic Exposure Scenarios. Radiat Res 187, 465-475, doi:10.1667/RR008CC.1 (2017). [Radiation Research]

Welch, D., Turner, L., Speiser, M., Randers-Pehrson, G. & Brenner, D. J. Scattered Dose Calculations and Measurements in a Life-Like Mouse Phantom. Radiat Res 187, 433-442, doi:10.1667/RR004CC.1 (2017). [Radiation Research]

Bian, D., Tsui, J. C., Repin, M., Garty, G., Turner, H., Lawrence Yao, Y. & Brenner, D. J. Liquid Handling Optimization in High-Throughput Biodosimetry Tool. J Med Device 10, 0410071-4100710, doi:10.1115/1.4033600 (2016). [Journal of Medical Devices]

Garty, G., Turner, H. C., Salerno, A., Bertucci, A., Zhang, J., Chen, Y., Dutta, A., Sharma, P., Bian, D., Taveras, M., Wang, H., Bhatla, A., Balajee, A., Bigelow, A. W., Repin, M., Lyulko, O. V., Simaan, N., Yao, Y. L. & Brenner, D. J. THE DECADE OF THE RABiT (2005-15). Radiat Prot Dosimetry 172, 201-206, doi:10.1093/rpd/ncw172 (2016). [Radiation Protection Dosimetry]

Bertucci, A., Smilenov, L. B., Turner, H. C., Amundson, S. A. & Brenner, D. J. In vitro RABiT measurement of dose rate effects on radiation induction of micronuclei in human peripheral blood lymphocytes. Radiat Environ Biophys 55, 53-59, doi:10.1007/s00411-015-0628-z (2016). [Radiation and Environmental Biophysics]

Turner, H. C., Shuryak, I., Weber, W., Doyle-Eisele, M., Melo, D., Guilmette, R., Amundson, S. A. & Brenner, D. J. gamma-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90. PLoS One 10, e0143815, doi:10.1371/journal.pone.0143815 (2015). [PLOS One]

Lue, S. W., Repin, M., Mahnke, R. & Brenner, D. J. Development of a High-Throughput and Miniaturized Cytokinesis-Block Micronucleus Assay for Use as a Biological Dosimetry Population Triage Tool. Radiat Res 184, 134-142 (2015). [Radiation Research]

Xu, Y., Randers-Pehrson, G., Turner, H. C., Marino, S. A., Geard, C. R., Brenner, D. J. & Garty, G. Accelerator-Based Biological Irradiation Facility Simulating Neutron Exposure from an Improvised Nuclear Device. Radiat Res 184, 404-410, doi:10.1667/RR14036.1 (2015). [Radiation Research]

Xu, Y., Randers-Pehrson, G., Marino, S. A., Garty, G., Harken, A. D. & Brenner, D. J. Broad Energy Range Neutron Spectroscopy using a Liquid Scintillator and a Proportional Counter: Application to a Neutron Spectrum Similar to that from an Improvised Nuclear Device. Nucl Instrum Methods Phys Res A 794, 234-239, doi:10.1016/j.nima.2015.05.041 (2016). [Nuclear Instruments and Methods in Physics Research]

Garty, G., Bigelow, A. W., Repin, M., Turner, H. C., Bian, D., Balajee, A. S., Lyulko, O. V., Taveras, M., Yao, Y. L. & Brenner, D. J. An automated imaging system for radiation biodosimetry. Microsc Res Tech 78, 587-598, doi:10.1002/jemt.22512 (2015). [Microscopy Research and Technique]

Sharma, P. M., Ponnaiya, B., Taveras, M., Shuryak, I., Turner, H. & Brenner, D. J. High throughput measurement of gammaH2AX DSB repair kinetics in a healthy human population. PLoS One 10, e0121083, doi:10.1371/journal.pone.0121083 (2015). [PLOS One]

Turner, H. C., Shuryak, I., Taveras, M., Bertucci, A., Perrier, J. R., Chen, C., Elliston, C. D., Johnson, G. W., Smilenov, L. B., Amundson, S. A. & Brenner, D. J. Effect of dose rate on residual gamma-H2AX levels and frequency of micronuclei in X-irradiated mouse lymphocytes. Radiat Res 183, 315-324, doi:10.1667/RR13860.1 (2015). [Radiation Research]

Halm, B. M., Franke, A. A., Lai, J. F., Turner, H. C., Brenner, D. J., V.M., Z. & DiMauro, R. γ-H2AX foci are increased in lymphocytes in vivo in young children 1 h after very low-dose X-irradiation: a pilot study. Pediatr Radiol 44, 1310-1317, doi:10.1007/s00247-014-2983-3 (2014). [Pediatric Radiology]

Repin, M., Turner, H. C., Garty, G. & Brenner, D. J. Next generation platforms for high-throughput biodosimetry. Radiat Prot Dosimetry 159, 105-110, doi:10.1093/rpd/ncu161 (2014). [Radiation Protection Dosimetry]

Lyulko, O. V., Garty, G., Randers-Pehrson, G., Turner, H. C., Szolc, B. & Brenner, D. J. Fast image analysis for the micronucleus assay in a fully automated high-throughput biodosimetry system. Radiat Res 181, 146-161, doi:10.1667/RR13441.1 (2014). [Radiation Research]

Turner, H. C., Sharma, P., Perrier, J. R., Bertucci, A., Smilenov, L., Johnson, G., Taveras, M., Brenner, D. J. & Garty, G. The RABiT: high-throughput technology for assessing global DSB repair. Radiat Environ Biophys 53, 265-272, doi:10.1007/s00411-014-0514-0 (2014). [Radiation and Environmental Biophysics]

Garty, G., Turner, H.C., Taveras, M., Lyulko, O.V., Randers-Pehrson, G., Brenner, D.J. The RABiT: A Rapid Automated Biodosimetry Tool, pp 397-400 In: The Medical Basis for Radiation-Accident Preparedness V: Medical Management. Eds: Christensen, D.M., Sugarman, S.L., O’Hara, F.M. [Medical Management]

Xu, Y., Turner, H. C., Garty, G. & Brenner, D. A Rapid, Quantitative Method to Characterize The Human Lymphocyte Concentration for Automated High-Throughput Radiation Biodosimetry. Biomed Eng Res 2, 16-19 (2013). [Biomedical Engineering Research]

Chen, Y., Wang, H., Zhang, J., Garty, G., Simaan, N., Yao, Y. L. & Brenner, D. J. Automated Recognition of Robotic Manipulation Failures in High-throughput Biodosimetry Tool. Expert Syst Appl 39, 9602-9611 (2012). [Expert Systems Applications]

Garty, G., Chen, Y., Turner, H. C., Zhang, J., Lyulko, O. V., Bertucci, A., Xu, Y., Wang, H., Simaan, N., Randers-Pehrson, G., Lawrence Yao, Y. & Brenner, D. J. The RABiT: a rapid automated biodosimetry tool for radiological triage. II. Technological developments. Int J Radiat Biol 87, 776-790, doi:10.3109/09553002.2011.573612 (2011). [International Journal of Radiation Biology]

Garty, G., Karam, A. & Brenner, D. J. Infrastructure to support ultra high throughput biodosimetry screening after a radiological event. Int J Radiat Biol 87, 754-765, doi:10.3109/09553002.2011.583317 (2011). [International Journal of Radiation Biology]

Turner, H. C., Brenner, D. J., Chen, Y., Bertucci, A., Zhang, J., Wang, H., Lyulko, O. V., Xu, Y., Shuryak, I., Schaefer, J., Simaan, N., Randers-Pehrson, G., Yao, Y. L., Amundson, S. A. & Garty, G. Adapting the gamma-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects. Radiat Res 175, 282-290, doi:10.1667/RR2125.1 (2011). [Radiation Research]

Garty, G., Chen, Y., Salerno, A., Turner, H., Zhang, J., Lyulko, O., Bertucci, A., Xu, Y., Wang, H., Simaan, N., Randers-Pehrson, G., Yao, Y. L., Amundson, S. A. & Brenner, D. J. The RABIT: a rapid automated biodosimetry tool for radiological triage. Health Phys 98, 209-217, doi:10.1097/HP.0b013e3181ab3cb6 (2010). [Health Physics]

Chen, Y., Zhang, J., Wang, H., Garty, G., Xu, Y., Lyulko, O. V., Turner, H. C., Randers-Pehrson, G., Simaan, N., Yao, Y. L. & Brenner, D. J. Development of a Robotically-based Automated Biodosimetry Tool for High-throughput Radiological Triage. IJBBR 1, 115-125 (2010). [International Journal of Biomechatronics and Biomedical Robotics]

Chen, Y., Zhang, J., Wang, H., Garty, G., Xu, Y., Lyulko, O. V., Turner, H. C., Randers-Pehrson, G., Simaan, N., Yao, Y. L. & Brenner, D. J. Design and Preliminary Validation of a Rapid Automated Biodosimetry Tool for High Throughput Radiological Triage. Proc ASME Des Eng Tech Conf 3, 61-67, doi:10.1115/DETC2009-86425 (2009).  [Proceedings ASME Design Engineering Technical Conference]

Salerno, A., Zhang, J., Bhatla, A., Lyulko, O. V., Nie, J., Dutta, A., Garty, G., Simaan, N., Randers-Pehrson, G., Yao, Y. L. & Brenner, D. J. Design Considerations for a Minimally Invasive High-Throughput Automation System for Radiation Biodosimetry. In: Proceedings of the Third Annual IEEE Conference on Automation Science and Engineering (CASE), Scottsdale, AZ, September 2007: 846-852; 2007. (2007). [Proceedings of the 3rd Annual IEEE CASE]

Broustas, C. G., Harken, A. D., Garty, G. & Amundson, S. A. Identification of differentially expressed genes and pathways in mice exposed to mixed field neutron/photon radiation. BMC Genomics 19, 504, doi:10.1186/s12864-018-4884-6 (2018). [BMC Genomics]

Lacombe, J., Sima, C., Amundson, S. A. & Zenhausern, F. Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review. PLoS One 13, e0198851, doi:10.1371/journal.pone.0198851 (2018). [PLoS One]

Suresh Kumar, M. A., Laiakis, E. C., Ghandhi, S. A., Morton, S. R., Fornace, A. J., Jr. & Amundson, S. A. Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays. Radiat Res 190, 53-62, doi:10.1667/RR14990.1 (2018). [Radiation Research]

Rudqvist, N., Laiakis, E. C., Ghandhi, S. A., Kumar, S., Knotts, J. D., Chowdhury, M., Fornace, A. J., Jr. & Amundson, S. A. Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation. Radiat Res 189, 337-344, doi:10.1667/RR14862.1 (2018). [Radiation Research]

Ghandhi, S. A., Turner, H. C., Shuryak, I., Dugan, G. O., Bourland, J. D., Olson, J. D., Tooze, J. A., Morton, S. R., Batinic-Haberle, I., Cline, J. M. & Amundson, S. A. Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. PLoS One 13, e0191402, doi:10.1371/journal.pone.0191402 (2018). [PLoS One]

Park, J. G., Paul, S., Briones, N., Zeng, J., Gillis, K., Wallstrom, G., LaBaer, J. & Amundson, S. A. Developing Human Radiation Biodosimetry Models: Testing Cross-Species Conversion Approaches Using an Ex Vivo Model System. Radiat Res 187, 708-721, doi:10.1667/RR14655.1 (2017). [Radiation Research]

Broustas, C. G., Xu, Y., Harken, A. D., Chowdhury, M., Garty, G. & Amundson, S. A. Impact of Neutron Exposure on Global Gene Expression in a Human Peripheral Blood Model. Radiat Res 187, 433-440, doi:10.1667/RR0005.1 (2017). [Radiation Research]

Broustas, C. G., Xu, Y., Harken, A. D., Garty, G. & Amundson, S. A. Comparison of gene expression response to neutron and x-ray irradiation using mouse blood. BMC Genomics 18, 2, doi:10.1186/s12864-016-3436-1 (2017). [BMC Genomics]

Bertucci, A., Smilenov, L. B., Turner, H. C., Amundson, S. A. & Brenner, D. J. In vitro RABiT measurement of dose rate effects on radiation induction of micronuclei in human peripheral blood lymphocytes. Radiat Environ Biophys 55, 53-59, doi:10.1007/s00411-015-0628-z (2016). [Radiat Environ Biophys]

Ghandhi, S. A., Weber, W., Melo, D., Doyle-Eisele, M., Chowdhury, M., Guilmette, R. & Amundson, S. A. Effect of 90Sr internal emitter on gene expression in mouse blood. BMC Genomics 16, 586, doi:10.1186/s12864-015-1774-z (2015). [BMC Genomics]

Turner, H. C., Shuryak, I., Taveras, M., Bertucci, A., Perrier, J. R., Chen, C., Elliston, C. D., Johnson, G. W., Smilenov, L. B., Amundson, S. A. & Brenner, D. J. Effect of dose rate on residual gamma-H2AX levels and frequency of micronuclei in X-irradiated mouse lymphocytes. Radiat Res 183, 315-324, doi:10.1667/RR13860.1 (2015). [Radiation Research]

Ghandhi, S. A., Smilenov, L. B., Elliston, C. D., Chowdhury, M. & Amundson, S. A. Radiation dose-rate effects on gene expression for human biodosimetry. BMC Med Genomics 8, 22, doi:10.1186/s12920-015-0097-x (2015). [BMC Medical Genomics]

Paul, S., Smilenov, L. B., Elliston, C. D. & Amundson, S. A. Radiation Dose-Rate Effects on Gene Expression in a Mouse Biodosimetry Model. Radiat Res 184, 24-32, doi:10.1667/RR14044.1 (2015). [Radiation Research]

Turner, H. C., Shuryak, I., Weber, W., Doyle-Eisele, M., Melo, D., Guilmette, R., Amundson, S. A. & Brenner, D. J. gamma-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90. PLoS One 10, e0143815, doi:10.1371/journal.pone.0143815 (2015). [PLOS One]

Sun, H., Olsen, T., Zhu, J., Tao, J., Ponnaiya, B., Amundson, S. A., Brenner, D. J. & Lin, Q. A Bead-Based Microfluidic Approach to Integrated Single-Cell Gene Expression Analysis by Quantitative RT-PCR. RSC Adv 5, 4886-4893, doi:10.1039/C4RA13356K (2015). [RSC Advances]

Paul, S. & Amundson, S. A. Differential Effect of Active Smoking on Gene Expression in Male and Female Smokers. J Carcinog Mutagen 5, doi:10.4172/2157-2518.1000198 (2014). [Journal of Carcinogenesis and Mutagenesis]

Luo, X., Suzuki, M., Ghandhi, S. A., Amundson, S. A. & Boothman, D. A. ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS One 9, e99983, doi:10.1371/journal.pone.0099983 (2014).[PLOS One]

Laiakis, E. C., Mak, T. D., Anizan, S., Amundson, S. A., Barker, C. A., Wolden, S. L., Brenner, D. J. & Fornace, A. J., Jr. Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res 181, 350-361, doi:10.1667/RR13567.1 (2014). [Radiation Research]

Brenner, D. J., Vazquez, M., Buonanno, M., Amundson, S. A., Bigelow, A. W., Garty, G., Harken, A. D., Hei, T. K., Marino, S. A., Ponnaiya, B., Randers-Pehrson, G. & Xu, Y. Integrated interdisciplinary training in the radiological sciences. Br J Radiol 87, 20130779, doi:10.1259/bjr.20130779 (2014). [British Journal of Radiology]

Brengues M., Smith S., Estes M., Zenhausern F. Integrated micro-fluidic system for gene expression based biodosimetry. In: Christensen D.M., Sugarman S.L. Editors. The medical basis for radiation accident preparedness v: Advances in diagnosis & management of ionizing radiation injuries & illnesses. Oak Ridge Associated Universities; 2013. p363-6. 

Paul, S., Smilenov, L. B. & Amundson, S. A. Widespread decreased expression of immune function genes in human peripheral blood following radiation exposure. Radiat Res 180, 575-583, doi:10.1667/RR13343.1 (2013). [Radiation Research]

Badie, C., Kabacik, S., Balagurunathan, Y., Bernard, N., Brengues, M., Faggioni, G., Greither, R., Lista, F., Peinnequin, A., Poyot, T., Herodin, F., Missel, A., Terbrueggen, B., Zenhausern, F., Rothkamm, K., Meineke, V., Braselmann, H., Beinke, C. & Abend, M. Laboratory intercomparison of gene expression assays. Radiat Res 180, 138-148, doi:10.1667/RR3236.1 (2013). [Radiation Research]

Rothkamm, K., Beinke, C., Romm, H., Badie, C., Balagurunathan, Y., Barnard, S., Bernard, N., Boulay-Greene, H., Brengues, M., De Amicis, A., De Sanctis, S., Greither, R., Herodin, F., Jones, A., Kabacik, S., Knie, T., Kulka, U., Lista, F., Martigne, P., Missel, A., Moquet, J., Oestreicher, U., Peinnequin, A., Poyot, T., Roessler, U., Scherthan, H., Terbrueggen, B., Thierens, H., Valente, M., Vral, A., Zenhausern, F., Meineke, V., Braselmann, H. & Abend, M. Comparison of established and emerging biodosimetry assays. Radiat Res 180, 111-119, doi:10.1667/RR3231.1 (2013). [Radiation Research]

Templin, T., Young, E. F. & Smilenov, L. B. Proton radiation-induced miRNA signatures in mouse blood: characterization and comparison with 56Fe-ion and gamma radiation. Int J Radiat Biol 88, 531-539, doi:10.3109/09553002.2012.690549 (2012). [International Journal of Radiation Biology]

Paul, S. & Amundson, S. A. Gene expression signatures of radiation exposure in peripheral white blood cells of smokers and non-smokers. Int J Radiat Biol 87, 791-801, doi:10.3109/09553002.2011.568574 (2011). [International Journal of Radiation Biology]

Templin, T., Amundson, S. A., Brenner, D. J. & Smilenov, L. B. Whole mouse blood microRNA as biomarkers for exposure to gamma-rays and (56)Fe ion. Int J Radiat Biol 87, 653-662, doi:10.3109/09553002.2010.549537 (2011). [International Journal of Radiation Biology]

Williams, P. D., Owens, C. R., Dziegielewski, J., Moskaluk, C. A., Read, P. W., Larner, J. M., Story, M. D., Brock, W. A., Amudson, S. A., Lee, J. K. & Theodorescu, D. Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy. Neoplasia 12, 1122-1131 (2011). [Neoplasia]

Amundson, S. A. & Smilenov, L. B. Integration of biological knowledge and gene expression data for biomarker selection: FN1 as a potential predictor of radiation resistance in head and neck cancer. Cancer Biol Ther 10, 1252-1255 (2010). [Cancer Biology]

Templin, T., Paul, S., Amundson, S. A., Young, E. F., Barker, C. A., Wolden, S. L. & Smilenov, L. B. Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys 80, 549-557, doi:10.1016/j.ijrobp.2010.12.061 (2011). [International Journal of Radiation Oncology, Biology, Physics]

Ghandhi, S. A., Sinha, A., Markatou, M. & Amundson, S. A. Time-series clustering of gene expression in irradiated and bystander fibroblasts: an application of FBPA clustering. BMC Genomics 12, 2, doi:10.1186/1471-2164-12-2 (2011). [BMC Genomics]

Paul, S., Barker, C. A., Turner, H. C., McLane, A., Wolden, S. L. & Amudson, S. A. Prediction of In Vivo Radiation Dose Status in Radiotherapy Patients using Ex Vivo and In Vivo Gene Expression Signatures. Radiat Res 175, 257-265, doi:10.1667/RR2420.1 (2011). [Radiation Research]

Huang, T. C., Paul, S., Gong, P., Levicky, R., Kymissis, J., Amundson, S. A. & Shepard, K. L. Gene expression analysis with an integrated CMOS microarray by time-resolved fluorescence detection. Biosens Bioelectron 26, 2660-2665, doi:10.1016/j.bios.2010.03.001 (2011). [Biosens Bioelectron]

Brengues, M., Paap, B., Bittner, M., Amudson, S. A., Seligmann, B., Korn, R., Lenigk, R. & Zenhausern, F. Biodosimetry on small blood volume using gene expression assay. Health Phys 2, 179-185, doi:10.1097/01.HP.0000346706.44253.5c. (2010). [Health Physics]

Garty, G., Chen, Y., Salerno, A., Turner, H., Zhang, J., Lyulko, O., Bertucci, A., Xu, Y., Wang, H., Simaan, N., Randers-Pehrson, G., Yao, Y. L., Amundson, S. A. & Brenner, D. J. The RABIT: a rapid automated biodosimetry tool for radiological triage. Health Phys 98, 209-217, doi:10.1097/HP.0b013e3181ab3cb6 (2010). [Health Physics]

Paul, S. & Amundson, S. A. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys 71, 1236-1244, doi:10.1016/j.ijrobp.2008.03.043 (2008). [International Journal of Radiation Oncology, Biology, Physics]

Straume, T., Amundson, S. A., Blakely, W. F., Burns, F. J., Chen, A., Dainiak, N., Franklin, S., Leary, J. A., Loftus, D. J., Morgan, W. F., Pellmar, T. C., Stolc, V., Turteltaub, K. W., Vaughan, A. T., Vijayakumar, S. & Wyrobek, A. J. NASA Radiation Biomarker Workshop, September 27-28, 2007. Radiat Res 170, 393-405, doi:10.1667/RR1382.1 (2008). [Radiation Research]

Amundson, S. A., Do, K. T., Vinikoor, L. C., Lee, R. A., Koch-Paiz, C. A., Ahn, J., Reimers, M., Chen, Y., Scudiero, D. A., Weinstein, J. N., Trent, J. M., Bittner, M. L., Meltzer, P. S. & Fornace, A. J., Jr. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res 68, 415-424, doi:10.1158/0008-5472.CAN-07-2120 (2008). [Cancer Research]

Amundson, S. A. Functional Genomics and a New Era in Radiation Biology and Oncology. Bioscience 58, 491-500, doi:10.1641/B580606 (2008). [Bioscience]

Amundson, S. A. Functional genomics in radiation biology: a gateway to cellular systems-level studies. Radiat Environ Biophys 47, 25-31, doi:10.1007/s00411-007-0140-1 (2008). [Radiation Environmental Biophysics]

Alexander, G., Swartz, H., Amundson, S.A., Blakely, W.F., Buddemeier, B., Gallez, B., Dainiak. N., Goans, R., Hayes, R., Jones, R., Lowry, P., Noska, M., Okunieff, P., Salner, A., Schauer, D., Trompier, F., Turteltaub, K., Voisin, P., Wiley, A.J., Wilkins, R. BiodosEPR-2006 Meeting: Acute Dosimetry Consensus Committee Recommendations on Biodosimetry Applications in Events Involving Terrorist Uses of Radioactive Materials and Radiation Accidents. Radiat Meas, 2007, 42:972-996. [Radiation Measures]

Representative Recent Publications

Laiakis, E. C., Canadell, M. P., Grilj, V., Harken, A. D., Garty, G. Y., Astarita, G., Brenner, D. J., Smilenov, L. & Fornace, A. J., Jr. Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype. Sci Rep 9, 4539, doi:10.1038/s41598-019-41083-7 (2019). [Scientific Reports]

Laiakis EC. Metabolomic applications in radiation biodosimetry. In: D’alessandro A, ed. Methods in Molecular Biology -High-thoughput metabolomics. Springer Nature; 2019. 

Pannkuk, E. L., Laiakis, E. C., Gill, K., Jain, S. K., Mehta, K. Y., Nishita, D., Bujold, K., Bakke, J., Gahagen, J., Authier, S., Chang, P. & Fornace, A. J., Jr. Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels. J Proteome Res, doi:10.1021/acs.jproteome.9b00101 (2019). [Journal of Proteome Research]

Pannkuk, E. L., Laiakis, E. C., Garcia, M., Fornace, A. J., Jr. & Singh, V. K. Nonhuman Primates with Acute Radiation Syndrome: Results from a Global Serum Metabolomics Study after 7.2 Gy Total-Body Irradiation. Radiat Res, doi:10.1667/RR15167.1 (2018). [Radiation Research]

Laiakis, E. C., Mak, T. D., Strawn, S. J., Wang, Y. W., Moon, B. H., Ake, P. & Fornace, A. J., Jr. Global metabolomic responses in urine from atm deficient mice in response to LD50/30 gamma irradiation doses. Environ Mol Mutagen 59, 576-585, doi:10.1002/em.22202 (2018). [Environmental and Molecular Mutagenesis]

Suresh Kumar, M. A., Laiakis, E. C., Ghandhi, S. A., Morton, S. R., Fornace, A. J., Jr. & Amundson, S. A. Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays. Radiat Res 190, 53-62, doi:10.1667/RR14990.1 (2018). [Radiation Research]

Chen, Z., Coy, S. L., Pannkuk, E. L., Laiakis, E. C., Fornace, A. J., Jr. & Vouros, P. Differential Mobility Spectrometry-Mass Spectrometry (DMS-MS) in Radiation Biodosimetry: Rapid and High-Throughput Quantitation of Multiple Radiation Biomarkers in Nonhuman Primate Urine. J Am Soc Mass Spectrom 29, 1650-1664, doi:10.1007/s13361-018-1977-z (2018). [Journal of the American Society for Mass Spectrometry]

Vera, N. B., Chen, Z., Pannkuk, E., Laiakis, E. C., Fornace, A. J., Jr., Erion, D. M., Coy, S. L., Pfefferkorn, J. A. & Vouros, P. Differential mobility spectrometry (DMS) reveals the elevation of urinary acetylcarnitine in non-human primates (NHPs) exposed to radiation. J Mass Spectrom 53, 548-559, doi:10.1002/jms.4085 (2018). [Journal of Mass Spectrometry]

Rudqvist, N., Laiakis, E. C., Ghandhi, S. A., Kumar, S., Knotts, J. D., Chowdhury, M., Fornace, A. J., Jr. & Amundson, S. A. Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation. Radiat Res 189, 337-344, doi:10.1667/RR14862.1 (2018). [Radiation Research]

Laiakis, E. C., Pannkuk, E. L., Chauthe, S. K., Wang, Y. W., Lian, M., Mak, T. D., Barker, C. A., Astarita, G. & Fornace, A. J., Jr. A Serum Small Molecule Biosignature of Radiation Exposure from Total Body Irradiated Patients. J Proteome Res 16, 3805-3815, doi:10.1021/acs.jproteome.7b00468 (2017). [Journal of Proteome Research]

Laiakis, E. C., Wang, Y. W., Young, E. F., Harken, A. D., Xu, Y., Smilenov, L., Garty, G. Y., Brenner, D. J. & Fornace, A. J., Jr. Metabolic Dysregulation after Neutron Exposures Expected from an Improvised Nuclear Device. Radiat Res 188, 21-34, doi:10.1667/RR14656.1 (2017). [Radiation Research]

Chen, Z., Coy, S. L., Pannkuk, E. L., Laiakis, E. C., Hall, A. B., Fornace, A. J., Jr. & Vouros, P. Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry. J Am Soc Mass Spectrom 27, 1626-1636, doi:10.1007/s13361-016-1438-5 (2016). [Journal of the American Society for Mass Spectrometry]

Goudarzi, M., Mak, T. D., Jacobs, J. P., Moon, B. H., Strawn, S. J., Braun, J., Brenner, D. J., Fornace, A. J., Jr. & Li, H. H. An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis. Radiat Res 186, 219-234, doi:10.1667/RR14306.1 (2016). [Radiation Research]

Pannkuk, E. L., Fornace, A. J., Jr. & Laiakis, E. C. Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules. Int J Radiat Biol 93, 1151-1176, doi:10.1080/09553002.2016.1269218 (2017). [International Journal of Radiation Biology]

Laiakis, E. C., Strawn, S. J., Brenner, D. J. & Fornace, A. J. Assessment of Saliva as a Potential Biofluid for Biodosimetry: A Pilot Metabolomics Study in Mice. Radiat Res 186, 92-97, doi:10.1667/RR14433.1. (2016). [Radiation Research]

Goudarzi, M., Chauthe, S., Strawn, S. J., Weber, W. M., Brenner, D. J. & Fornace, A. J. Quantitative Metabolomic Analysis of Urinary Citrulline and Calcitroic Acid in Mice after Exposure to Various Types of Ionizing Radiation. Int J Mol Sci 17, doi:10.3390/ijms17050782 (2016). [International Journal of Molecular Sciences]

Goudarzi, M., Weber, W. M., Chung, J., Doyle-Eisele, M., Melo, D. R., Mak, T. D., Strawn, S. J., Brenner, D. J., Guilmette, R. & Fornace, A. J. Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography-Mass Spectrometry Approach. J Proteome Res 14, 4039-4049, doi:10.1021/acs.jproteome.5b00576 (2015). [Journal of Proteome Research]

Goudarzi, M., Weber, W. M., Mak, T. D., Chung, J., Doyle-Eisele, M., Melo, D. R., Strawn, S. J., Brenner, D. J., Guilmette, R. A. & Fornace, A. J., Jr. A Comprehensive Metabolomic Investigation in Urine of Mice Exposed to Strontium-90. Radiat Res 183, 665-674, doi:10.1667/RR14011.1 (2015). [Radiation Research]

Laiakis, E. C., Pannkuk, E. L., Diaz-Rubio, M. E., Wang, Y. W., Mak, T. D., Simbulan-Rosenthal, C. M., Brenner, D. J. & Fornace, A. J., Jr. Implications of genotypic differences in the generation of a urinary metabolomics radiation signature. Mutat Res 788, 41-49, doi:10.1016/j.mrfmmm.2016.03.003 (2016). [Mutation Research]

Mak, T. D., Laiakis, E. C., Goudarzi, M. & Fornace, A. J., Jr. Selective paired ion contrast analysis: a novel algorithm for analyzing postprocessed LC-MS metabolomics data possessing high experimental noise. Anal Chem 87, 3177-3186, doi:10.1021/ac504012a (2015). [Analytical Chemistry]

Mak, T. D., Tyburski, J. B., Krausz, K. W., Kalinich, J. F., Gonzalez, F. J. & Fornace, A. J., Jr. Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat. Metabolomics 11, 1082-1094, doi:10.1007/s11306-014-0765-4 (2015). [Metabolomics]

Goudarzi, M., Weber, W. M., Mak, T. D., Chung, J., Doyle-Eisele, M., Melo, D. R., Brenner, D. J., Guilmette, R. A. & Fornace, A. J., Jr. Metabolomic and lipidomic analysis of serum from mice exposed to an internal emitter, cesium-137, using a shotgun LC-MS(E) approach. J Proteome Res 14, 374-384, doi:10.1021/pr500913n (2015). [Journal of Proteome Research]

Hyduke, D. R., Laiakis, E. C., Li, H. H. & Fornace, A. J., Jr. Identifying radiation exposure biomarkers from mouse blood transcriptome. Int J Bioinform Res Appl 9, 365-385, doi:10.1504/IJBRA.2013.054701 (2013). [International Journal of Bioinformatics Research and Applications]

Laiakis, E. C., Strassburg, K., Bogumil, R., Lai, S., Vreeken, R. J., Hankemeier, T., Langridge, J., Plumb, R. S., Fornace, A. J., Jr. & Astarita, G. Metabolic phenotyping reveals a lipid mediator response to ionizing radiation. J Proteome Res 13, 4143-4154, doi:10.1021/pr5005295 (2014). [Journal of Proteome Research]

Goudarzi, M., Mak, T. D., Chen, C., Smilenov, L. B., Brenner, D. J. & Fornace, A. J. The effect of low dose rate on metabolomic response to radiation in mice. Radiat Environ Biophys 53, 645-657, doi:10.1007/s00411-014-0558-1 (2014). [Radiation and Environmental Biophysics]

Goudarzi, M., Weber, W., Mak, T. D., Chung, J., Doyle-Eisele, M., Melo, D., Brenner, D. J., Guilmette, R. A. & Fornace, A. J. Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res 181, 54-64, doi:10.1667/RR13479.1 (2014). [Radiation Research]

Mak, T. D., Laiakis, E. C., Goudarzi, M. & Fornace, A. J., Jr. MetaboLyzer: a novel statistical workflow for analyzing Postprocessed LC-MS metabolomics data. Anal Chem 86, 506-513, doi:10.1021/ac402477z (2014). [Analytical Chemistry]

Laiakis, E. C., Bogumil, R., Roehring, C., Daxboeck, M., Lai, S., Breit, M., Shockor, J., Cohen, S., Langridge, J., Fornace, A. J. & Astarita, G. Targeted Metabolomics Using the UPLC/MS-based AbsoluteIDQ p180 Kit. [Waters Corporation, Application Note]

Laiakis, E. C., Mak, T. D., Anizan, S., Amundson, S. A., Barker, C. A., Wolden, S. L., Brenner, D. J. & Fornace, A. J., Jr. Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res 181, 350-361, doi:10.1667/RR13567.1 (2014). [Radiation Research]

Laiakis, E. C., Hyduke, D. R. & Fornace, A. J. Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors gamma radiation and lipopolysaccharide. Radiat Res 177, 187-199 (2012). [Radiation Research]

Coy, S. L., Cheema, A. K., Tyburski, J. B., Laiakis, E. C., Collins, S. P. & Fornace, A., Jr. Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol 87, 802-823, doi:10.3109/09553002.2011.556177 (2011). [International Journal of Radiation Biology]