Erik F. Young, Ph.D.

Contact Information

Center for Radiological Research
VC 11-239
630 W. 168th St.
New York, NY 10032

Tel: (212) 305-5661
Fax: (212) 305-3229
email: efy1@columbia.edu

Research Interests

  • Biological Impedance

  • Bioelectric sensing and surveillance

  • Cellular management and promulgation of damage information

  • Cell-cell and cell-matrix interactions

    Academic Training and History  

 

Undergraduate:

B.S., Loyola Marymount University

 

Graduate:

M.Phil., Columbia University

Ph.D., Columbia University

 

Post Graduate:

Research Scientist, Hackensack University Medical Center

Post-Doctoral:

Center for Radiological Research, College of Physicians & Surgeons of Columbia University Medical Center

 


   Current Academic and Professional Appointments  

  • Member, New York Academy of Sciences

  • Ad hoc reviewer, Advances in Space Research.

   Current Research  

My research interests involve development of bioimpedance and biological sensing modalities in radiation biology. I would like to learn to best employ bioelectric modalities as a way of learning about damage information in living systems. I'd also like to find out how physical connections between cells and their environment are important in the movement of this information.

My supervisors and funding have directed me into two different areas:

+ Study of DNA damage sensor threshold in mouse embryonic fibroblasts - Here, we are examining genetic effects on radiation sensitivity of a classically observed G2M arrest in response to radiation. This work is conducted under the auspices of the DOE's Low Dose Research Program. The main goals of the work are to examine genetic contributions toward checkpoint function in the context of lower doses to radiation. In the course of these studies we will establish the threshold of distinction and the threshold of detection for this biological sensing mechanism.

+ Bioelectric dosimetry modalities. Our current work involves the investigation of the electrically measurable responses to radiation exposure and the assessment of those modalities for high throughput dosimetry. Funding here is provided via a CMCR award.

Like many others, I end up building a fair number of the things I need to get the answers I need. My portfolio of engineering projects is available for perusal on request. One example is a time lapse video microscopy system I made from spare parts around the lab that generated the movie shown here below:

   Selected Publications  

  • Young EF, Smilenov LB. Impedance-Based Surveillance of Transient Permeability Changes in Coronary Endothelial Monolayers after Exposure to Ionizing Radiation. Radiat Res. 2011 Oct;176(4):415-24. Epub 2011 Aug 23. [Abstract] [PDF] [PMID: 21861763]. >>>Interview and movies<<<

  • Templin T, Paul S, Amundson SA, Young EF, Barker CA, Wolden SL, Smilenov LB. Radiation-Induced Micro-RNA Expression Changes in Peripheral Blood Cells of Radiotherapy Patients. Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):549-57. Epub 2011 Mar 21. [Abstract] [PDF] [PMID: 21420249].

  • Young EF, Quinn DA, Davies RJ. Interrogation of the rat mammary gland using intraductal impedance spectroscopy. Physiol Meas. 2010 Mar;31(3):451-60. Epub 2010 Feb 23. [Abstract] [PDF] [PMID: 20177141].

  • Young EF, Marcantonio EE.A novel subcellular collagen organization process visualized by total internal reflection fluorescence microscopy.Cell Commun Adhes. 2007 Sep-Oct;14(5):169-80. [Abstract] [PDF] [PMID: 18163228]

  • Kim HE, Dalal SS, Young E, Legato MJ, Weisfeldt ML, D'Armiento J. Disruption of the myocardial extracellular matrix leads to cardiac dysfunction. J Clin Invest. Oct;106(7):857-66, 2000. [Abstract] [PDF] [PMID: 11018073]

 

Updated 04/16/10

 

Search CRR:   

  Home | About us | Directions | Seminars | Directory | RARAF | Instrument Shop | Reports | E-mail

 

CRR Home
Overview
Research
Personnel
Facilities
Events & Dissemination
E-mail
About us
Directions
Search
Eric J. Hall, D.Phil.
Charles R. Geard
David J. Brenner
Tom K. Hei
Howard B. Lieberman
Sally A. Amundson
Lubomir B. Smilenov
Yongliang Zhao
Directory
Group Picture
RARAF
Instument Shop
Colloquia & Seminars
CRR Annual report
Event pictures
2009
2008
2007
2006
2005
2004
2003
2002
2001
2000
1999
1998
2006 Holiday Party
2008 CRR Picnic
Symposium 2008
2009 CRR Picnic
2010 CRR Picnic
U19 retreat 2010
Science Sessions
Reception and Banquet
Send your questions/comments