Cellular management and promulgation of damage information
Cell-cell and cell-matrix interactions
Academic Training and History
Undergraduate:
B.S.,
Loyola Marymount University
Graduate:
M.Phil., Columbia University
Ph.D., Columbia University
Post Graduate:
Research Scientist, Hackensack University Medical Center
Post-Doctoral:
Center for Radiological Research, College of Physicians &
Surgeons of Columbia University Medical Center
Current
Academic and Professional Appointments
Member, New York Academy of Sciences
Ad hoc reviewer, Advances in Space Research.
Current
Research
My research interests involve development of bioimpedance and biological sensing modalities in radiation biology.
I would like to learn to best employ bioelectric modalities as a way of learning about damage information in living systems. I'd also like to
find out how physical connections between cells and their environment are important in the movement of this information.
My supervisors and funding have directed me into two different areas:
+ Study of DNA damage sensor threshold in mouse embryonic fibroblasts - Here, we are examining genetic effects on
radiation sensitivity of a classically observed G2M arrest in response to radiation. This work is conducted under the auspices of the DOE's
Low Dose Research Program. The main goals of the work are to examine genetic contributions toward
checkpoint function in the context of lower doses to radiation. In the course of these studies we will establish the threshold of distinction
and the threshold of detection for this biological sensing mechanism.
+ Bioelectric dosimetry modalities. Our current work involves the investigation of the electrically measurable responses to
radiation exposure and the assessment of those modalities for high throughput dosimetry. Funding here is provided via a
CMCR award.
Like many others, I end up building a fair number of the things I need to get the answers I need. My
portfolio of
engineering projects is available for perusal on request. One example is a time lapse video microscopy system I made from spare parts
around the lab that generated the movie shown here below:
Selected Publications
Young EF, Smilenov LB. Impedance-Based Surveillance
of Transient Permeability Changes in Coronary Endothelial Monolayers after Exposure
to Ionizing Radiation. Radiat Res. 2011 Oct;176(4):415-24. Epub 2011 Aug 23. [Abstract] [PDF] [PMID:
21861763]. >>>Interview
and movies<<<
Templin T, Paul S, Amundson SA, Young EF, Barker CA,
Wolden SL, Smilenov LB. Radiation-Induced Micro-RNA Expression Changes in
Peripheral Blood Cells of Radiotherapy Patients. Int J Radiat Oncol Biol Phys. 2011 Jun 1;80(2):549-57. Epub
2011 Mar 21. [Abstract]
[PDF]
[PMID: 21420249].
Young EF, Quinn DA, Davies RJ. Interrogation of the
rat mammary gland using intraductal impedance spectroscopy. Physiol Meas. 2010
Mar;31(3):451-60. Epub 2010 Feb 23. [Abstract] [PDF]
[PMID: 20177141].
Young EF, Marcantonio EE.A novel subcellular
collagen organization process visualized by total internal reflection
fluorescence microscopy.Cell Commun Adhes. 2007 Sep-Oct;14(5):169-80. [Abstract] [PDF]
[PMID: 18163228]
Kim HE, Dalal SS, Young E, Legato MJ, Weisfeldt
ML, D'Armiento J. Disruption of the myocardial extracellular matrix leads to
cardiac dysfunction. J Clin Invest. Oct;106(7):857-66, 2000. [Abstract] [PDF]
[PMID: 11018073]
