Word of the Week: Biodosimetry

Biodosimetry
Biodosimetry is a measurement of biological response to radiation dose, using biomarkers.
 
 
Examples of Biomarkers used for Biodosimetry
 
Cytokinesis Blocked Micronucleus Assay: The Cytokinesis Blocked Micronucleus assay (CBMN) quantifies radiation-induced chromosome damage expressed as post-mitotic micronuclei, in once-divided cells.
 
γ-H2AXAssay: The γ-H2AX assay scores DNA double strand breaks by quantifying phosphorylation of the histone H2AX which co-localizes to them.
 
Dicentrics Assay: The Dicentrics Assay uses FISH telomeric probes and a counter stain to identify the end of each chromosome, and FISH centromeric probes to locate chromosome centromeres. Identified chromosomes containing two centromeric probes would thus be dicentrics.

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