Vladimir N. Ivanov,
Ph.D., D.Sc.

Contact Information

Center for Radiological Research
VC 11-236
630 W. 168th St.
New York, NY 10032

Tel: (212) 305-9667
Fax: (212) 305-3229
E mail: vni3@columbia.edu

Research Interests

  • Cell signaling and gene expression in radiation induced bystander response

  • Signaling pathways in neural stem cells induced by stress treatment
  • Radiosensitization and chemosensitization of human melanomas using targeted therapy to selectively increase apoptosis

  Academic Training    

Undergraduate:

B.S., Genetics, Novosibirsk University, Novosibirsk, Russia, 1970

Graduate:

Ph.D., Biochemistry, Russian Academy of Sciences, Moscow, Russia, 1977

D.Sc., Molecular Genetics, Russian Academy of Sciences, Moscow, Russia, 1990

Postdoctoral Training:

Molecular and Cell Immunology, Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculte de Medecine, University of Strasbourg, Strasbourg, France, 1991-1993

Molecular and Cell Immunology, Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida, 1993-1995


   Current Academic and Professional Appointments  

  • Research Scientist, Center for Radiological Research, College of Physicians & Surgeons of Columbia University

  • Member of American Association of Immunologists

  • Member of American Association for Cancer Research

  • Reviewer: Cancer Research, Carcinogenesis, Oncogene, Molecular Carcinogenesis, Journal of Biological Chemistry, BBRC, International Journal of Cancer, Journal of Immunology

   Current Research  

Radiation induced bystander response: cell signaling and gene expression




 

   Select Publications Online  

If you did not find what you are looking for below, try searching for Vladimir Ivanov on PubMed.

  • Ivanov VN, Hei TK.Induction of apoptotic death and retardation of neuronal differentiation of human neural stem cells by sodium arsenite treatment. Exp. Cell Res, 319:875-887, 2013. [abstract]
  • Ivanov VN, Wen G, Hei TK. Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. Apoptosis, 18:188-200, 2013. [abstract]
  • Ivanov V.N., and Hei, T.K. Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: A role of combined treatment versus monotherapy. Apoptosis, 16:1268-1284, 2011. [abstract]
  • Hei, TK., Zhao, Y., Zhou, H., and Ivanov V. Mechanism of radiation carcinogenesis: Role for the TGFBI gene and the inflammatory signaling cascade. Adv. Exp. Med. Biol., 720:163-170, 2011. [abstract]
  • Ivanov V.N., Ghandhi, S.A., Zhou, H., Huang, S.X., Chai, Y., Amundson, S.A., Hei, T.K. Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: A role for NF-?B-STAT3-directed gene expression. Exp. Cell Res., 317:1548-1566, 2011 . [abstract]
  • Hei, T.K., Zhou, H., Chai., Y, Ponnaiya, B., Ivanov V.N. Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications. Curr. Mol. Pharmacol. 4:96-105, 2011. [abstract]
  • Ivanov V.N., Partridge, M.A., Huang, S.X., Hei, T.K. Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis. J. Cell Biochem., 112:461-475, 2011. [abstract]
  • Ghandhi, S.A., Ming, L., Ivanov V.N., Hei, T.K., Amundson, S.A. Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts. BMC Med Genomics., 3:31, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20670442]
  • Karasic, T.B., Hei, T.K., Ivanov V.N. Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: A new potential therapy for the treatment of melanoma. Exp. Cell Res., 316:1994-2007, 2010. [abstract]
  • Ivanov VN, Zhou H, Ghandhi SA, Karasic TB, Yaghoubian B, Amundson SA, Hei TK. Radiation-induced bystander signaling pathways in human fibroblasts: A role for interleukin-33 in the signal transmission. Cell Signal. 22:1076-87, 2010. [abstract]

  • Ivanov VN, Zhou H, Partridge MA, Hei TK. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer Res. 69:3510-9, 2009. [abstract]

  • Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA and Geard CR. Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol. 60:943-50, 2008. [abstract]

  • Johnson GE, Ivanov VN and Hei TK. Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. Apoptosis 13:790-802, 2008. [abstract]

  • Zhou H, Ivanov VN, Lien YC, Davidson M and Hei TK. Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res 68:2233-40, 2008. [abstract]

  • Ivanov VN, Partridge MA, Johnson GE, Huang SX, Zhou H and Hei TK. Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res 314:1163-76, 2008. [abstract]

  • Ivanov VN, Zhou H and Hei TK. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res 67:5397-407, 2007. [abstract]

  • Ivanov VN and Hei TK. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res 312:4120-38, 2006. [abstract]

  • Ivanov VN and Hei TK. Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Exp. Cell Res. 312:1401-17, 2006. [abstract]

  • Ivanov VN, Ronai Z and Hei TK. Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis. J. Biol. Chem. 281:1840-52, 2006. [abstract]

  • Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, Yu Z, Lieberman HB and Hei TK. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc. Natl. Acad. Sci. USA 102:14641-6, 2005. [abstract]

  • Liu SX, Davidson MM, Tang X, Walker WF, Athar M, Ivanov V, and Hei TK. Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells. Cancer Research 65:3236-42, 2005. [abstract]

  • Ivanov VN and Hei TK. Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway. Oncogene 24:616-26, 2005. [abstract]

  • Ivanov VN and Hei TK. Arsenic sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathways. Journal of Biological Chemistry 279:22747-22758, 2004. [abstract]

  • Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA and Lerman MI. STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets. J Mol Biol 340:641-53, 2004. [abstract]

  • Ivanov VN, Lopez Bergami P, Maulit G, Sato TA, Sassoon D and Ronai Z. FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface. Mol Cell Biol 23:3623-35, 2003. [abstract]

  • Krasilnikov M, Ivanov VN, Dong J and Ronai Z. ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis. Oncogene 22:4092-101, 2003. [abstract]

  • Ivanov VN, Bhoumik A and Ronai Z. Death receptors and melanoma resistance to apoptosis. Oncogene 22:3152-61, 2003. [abstract]

  • Ivanov VN, Krasilnikov M and Ronai Z. Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 277:4932-44, 2002. [abstract]

  • Bhoumik A, Huang TG, Ivanov V, Gangi, L, Qiao, R. F., Woo, S. LC., Chen, S.-H., and Ronai, Z. An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis. J. Clin. Invest. 110: 643-50, 2002.

  • Ivanov VN, Bhoumik A, Krasilnikov M, Raz R, Owen-Schaub LB, Levy D, Horvath CM and Ronai Z. Cooperation between STAT3 and c-Jun suppresses Fas transcription. Mol Cell 7:517-28, 2001. [abstract]

  • Ivanova TV, Ivanov VN and Nadezhdina ES. Transcription factors NF-kappaB and AP-1/c-fos in cell response to nocodazole. Membr Cell Biol. 14:727-41, 2001. [abstract]

  • Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B and Ronai Z. TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage. Mol Cell Biol 21:8398-413, 2001. [abstract]

  • Ivanov VN, Fodstad O and Ronai Z. Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFα and suppression of NF-κB activities. Oncogene 20:2243-53, 2001. [abstract]

  • Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, et al. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 21:2743-54, 2001. [abstract]

  • Bhoumik A, Ivanov V and Ronai Z. Activating transcription factor 2-derived peptides alter resistance of human tumor cell lines to ultraviolet irradiation and chemical treatment. Clin Cancer Res 7:331-42, 2001. [abstract]

  • Rona, Z, Ivanov VN and Bhoumik A. Role of MAPK-p38 in radiation resistance of human melanoma. Cancer Detection and Prevention 24 (Suppl. 1), 2000.

  • Yin Z, Ivanov VN, Habelhah H, Tew K and Ronai Z. Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases. Cancer Res 60:4053-7, 2000. [abstract]

  • Ivanov VN and Ronai Z. p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression. Oncogene 19:3003-12, 2000. [abstract]

  • Ivanov VN, Kehrl JH and Ronai Z. Role of TRAF2/GCK in melanoma sensitivity to UV-induced apoptosis. Oncogene 19:933-42, 2000. [abstract]

  • Guevara Patino JA, Ivanov VN, Lacy E, Elkon KB, Marino MW and Nikolic-Zugic J. TNFα is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes. J Immunol. 164:1689-94, 2000. [abstract]

  • Guevara Patino JA, Marino MW, Ivanov VN and Nikolich-Zugich J. Sex steroids induce apoptosis of CD8+CD4+ double-positive thymocytes via TNFα. Eur J Immunol 30:2586-92, 2000. [abstract]

  • Ivanov VN and Ronai Z. Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells. J Biol Chem 274:14079-89, 1999. [abstract]

  • Ivanov VN and Nikolic-Zugic J. Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4+CD8+ thymocytes. Int Immunol 10:1807-17, 1998. [abstract]

  • Ivanov VN and Nikolic-Zugic J. Transcription factor activation during signal-induced apoptosis of immature CD4(+)CD8(+) thymocytes. A protective role of c-Fos. J Biol Chem 272:8558-66, 1997. [abstract]

  • Ivanov VN, Lee RK, Podack ER and Malek TR. Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-κB. Oncogene 14:2455-64, 1997. [abstract]

  • Ivanov VN, Deng G, Podack ER and Malek TR. Pleiotropic effects of Bcl-2 on transcription factors in T cells: potential role of NF-κB p50-p50 for the anti-apoptotic function of Bcl-2. Int Immunol 7:1709-20, 1995. [abstract]

  • Ivanov V, Fleming TJ and Malek TR. Regulation of nuclear factor-kappa B and activator protein-1 activities after stimulation of T cells via glycosylphosphatidylinositol-anchored Ly-6A/E. J Immunol 153:2394-406, 1994. [abstract]

  • Ivanov V, Fleming T and Malek T. Selective targeting of nuclear transcription factors following activation of T-cells via Ly-6, Thy-1 or T-cell receptor. J Cell Biochem. Suppl. 18D: 356, 1994.

  • Ivanov V, Merkenschlager M and Ceredig R. Antioxidant treatment of thymic organ cultures decreases NF-κB and TCF1(α) transcription factor activities and inhibits alpha beta T cell development. J Immunol 151:4694-704, 1993. [abstract]

  • Iudinkova ES, Tkach TM, Ivanov VN and Gorodetskii, S.I. Cloning the Bos taurus beta-lactoglobulin gene. Dokl. Acad. Nauk 332: 99-104, 1993.

  • Ivanov V and Ceredig R. Transcription factors in mouse fetal thymus development. Int Immunol 4:729-37, 1992. [abstract]

  • Ivanov VN and Villiams RO. [Activation of trans-acting transcription factors in T-lymphocytes infected by the intracellular parasitic protozoan Theileria parva]. Genetika 27:197-209, 1991. [abstract]

  • Ivanov VN, Kabishev AA, Gorodetskii SI and Gribanovskii VA. [Activation of a trans-activating factor of NF1 transcription in a lactating mammary gland]. Mol Biol (Mosk) 24:1605-15, 1990. [abstract]

  • Herrlich P, Ponta H, Stein B, Jonat C, Gebel S, Konig H, Williams RO, Ivanov VN and Rahmsdorf H. Transcription factors in normal and malignant cells. In: Molecular Biology of Cancer Genes (ed. M. Sluyser), Ellis Howard Series in Biomedicine, Amsterdam, pp.150-168, 1990.

  • Ivanov V, Stein B, Baumann I, Dobbelaere DA, Herrlich P and Williams RO. Infection with the intracellular protozoan parasite Theileria parva induces constitutively high levels of NF-κB in bovine T lymphocytes. Mol Cell Biol 9:4677-86, 1989. [abstract]

  • Ivanov VN, Judinkova ES and Gorodetsky SI. Molecular cloning of bovine beta-lactoglobulin cDNA. Biol Chem Hoppe Seyler 369:425-9, 1988. [abstract]

  • Ivanov VN, Karginov VA, Morozov IV and Gorodetsky SI. Molecular cloning of a bovine immunoglobulin lambda chain cDNA. Gene 67:41-8, 1988. [abstract]

  • Gorodetsky SI, Dyban AP, Waisman BL, Golinsky GP, Popkova GA, Arkhangelskaya IP, Zykova TA, Sekirina GG, Ivanov VN and Kapelinskaya TV. Growth stimulation and inhibition in mice bearing the human growth hormone gene. Bull. Exp. Biol. Med. 102:257-264, 1986.

  • Gorodetskii SI, Kiarshulite DR, Ivanov VN, Kapelinskaia TV and Kaledin AS. [Synthesis and cloning of DNA complementary to mRNA of the bovine mammary gland]. Genetika 21:191-200, 1985. [abstract]

  • Ivanov VN, Kershulite DR, Baev AA, Akhundova AA and Sulimova GE. [Identification of bacterial clones that encode cow's caseins by direct immunological screening of the cDNA library]. Mol Biol (Mosk) 19:955-63, 1985. [abstract]

  • Ivanov VN, Kershulite DR, Bayev AA, Akhundova AA, Sulimova GE, Judinkova ES and Gorodetsky SI. Identification of bacterial clones encoding bovine caseins by direct immunological screening of the cDNA library. Gene 32:381-8, 1984. [abstract]

  • Gorodetskii SI, Sulimova GE, Popendikite V, Mil'shina NV and Ivanov VN. [Isolation and characteristics of poly(A+) RNA in the lactating bovine udder]. Biokhimiia 49:633-43, 1984. [abstract]

  • Kershulite DR, Ivanov VN, Kapelinskaia TV, Kaledin AS and Gorodetskii SI. [Cloning of cDNA containing the sequence for mRNA of bovine alpha sl-casein]. Dokl Akad Nauk SSSR 271:1502-4, 1983.

 

Updated 04/27/10

[an error occurred while processing this directive]