bio

 Jingsong Yuan, MD., PhD.

Assistant Professor of Radiation Oncology

Center for Radiological Research
Department of Radiation Oncology

Contact Information: 

Center for Radiological Research
630 West 168th Street
VC 11-213
New York, NY 10032

Telephone: (212)305-5699
Fax: (212)305-3229

Email: jy2754@cumc.columbia.edu

 

Education

12/2011 – 08/2015: Assistant Professor, Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, USA

 

06/2010 - 11/2011       Instructor, Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, USA

 

07/2009 - 05/2010: Postdoctoral Fellow with Dr. Junjie Chen, Department of Experimental Radiation Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, USA

 

01/2007 - 06/2009: Postdoctoral Associate with Dr. Junjie Chen, Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, USA

 

09/2001 - 07/2006: Ph.D., Specialty: Oncology, Department of Etiology and Carcinogenesis, Cancer Institute (Hospital), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&PUMC), Beijing, China

 

09/1996 - 06/2001: M.D., Specialty: Clinical Medicine, School of Clinical Medicine, Tongji Medical University, Wuhan, China

 

Research

Dr. Jingsong Yuan's research goal is to leverage his expertise in the field of DNA damage repair for translation into the realm of cancer biology and therapeutics.

Dr. Yuan's main interest is in the underlying molecular mechanisms that result in genomic instability and tumorigenesis, specifically, in understanding the molecular mechanisms underlying DNA replication stress response and homologous recombination (HR) DNA repair, the function of which is critical for preventing genomic instability and tumorigenesis. Dr. Yuan and his colleagues identified the roles of two annealing helicases, HARP/SMARCAL1 and AH2/ZRANB3, in stabilizing stalled replication forks, facilitating DNA repair and maintaining genome stability in response to replication stress. He showed that DNA double-strand breaks (DSBs)-induced DNA damage signaling cascade and HR-mediated DSB repair pathway can be genetically separated. He reported that the MRN (MRE11-RAD50-NBS1) complex is responsible for initial recognition of DSBs, it then works together with CtIP, a binding partner of BRCA1, and the H2AX-dependent DNA damage-signaling cascade to facilitate HR repair and DNA damage checkpoint activation. Dr. Yuan uncovered human SWI5-MEI5 complex and FIGNL1 complex, and showed that they have an evolutionarily conserved function in HR repair. Most recently, Dr. Yuan’s group identified ETAA1 (Ewing tumor-associated antigen 1), also known as ETAA16, as a novel ATR activator involved in replication and DNA damage checkpoint control, and therefore provided a plausible explanation for why variants at ETAA1 loci increase the risk of developing cancer.

Selected Activities

2011-present    Editorial Member of the International Advisory Board of the Journal of Clinical Pathology

2012-present    Active Member of American Association for Cancer Research (AACR)

2013-present    Member of Radiation Research Society

Publications

Lee YC, Zhou Q, Chen J, Yuan J. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Curr Biol. 2016 Nov 2. pii: S0960-9822(16)31256-8. doi: 10.1016/j.cub.2016.10.030. [Epub ahead of print].

Liu L, Huang J, Wang K, Li L, Li Y, Yuan J, Wei S. Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing. Oncotarget. 2015 Nov 10;6(35):38016-28.

Xu G, Chapman R*, Brandsma I*, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers J, Watanabe K, Pieterse M, Kersbergen A, Sol W, Celie P, Schouten P, Broek B, Salman A, Nieuwland M, Rink I, Ronde J, Jalink K, Boulton S, Chen J, Gent D, Bartek J, Jonkers J, Borst P, Rottenberg S. REV7 counteracts DNA double-strand break resection and impacts PARP inhibition. Nature. 2015 Mar 23. doi: 10.1038/nature14328.

Zhang P, Wang L, Debeb B, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward W, Liu Y, Dean D, Ang K, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep;16(9):864-75.

Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10640-5.

Ling B, Zheng H, Fu G, Yuan J, Shi T, Chen S, Liu Y, Liu Y, Cao Y, Zheng S, Guo S, Han N, Gao Y, Cheng S, Zhang K. Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D. Lung Cancer. 2013 Feb;79(2):104-10.

Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71.

Yuan J, Ghosal G, Chen J. The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress. Mol Cell. 2012 Aug 10;47(3):410-21. (Highlighted in Mol Cell - Finally, polyubiquitinated PCNA gets recognized)

Ghosal G*, Yuan J*, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep. 2011 Jun;12(6):574-80. (*co-first and co-corresponding authors).

Yuan J, Chen J. The role of human SWI5-MEI5 complex in homologous recombination repair. J Biol Chem. 2011 Mar 18;286(11):9888-93.

Liu T, Ghosal G, Yuan J, Chen J, Huang J. FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science. 2010 Aug 6;329(5992):693-6. (Highlighted in Mol Cell - DNA repair has a new FAN1 club)

Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: To be or not to be. FEBS Lett. 2010 Sep 10;584(17):3717-24.

Yuan J, Chen J. MRN complex dictates DNA repair independent of H2AX. J Biol Chem. 2010 Jan 8;285(2):1097-104.

Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev. 2009 Oct 15;23(20):2394-9. (Highlighted in Genes Dev. - HARPing on about the DNA damage response during replication)

Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination mediated double-strand break repair. J Biol Chem. 2009 Nov 13;284(46):31746-52.

Yuan J, Ma J, Zheng H, Shi T, Sun W, Zhang Q, Lin D, Zhang K, He J, Mao Y, Gao X, Gao P, Han N, Fu G, Xiao T, Gao Y, Ma D, Cheng S. Overexpression of OLC1, cigarette smoke, and human lung tumorigenesis. J Natl Cancer Inst. 2008 Nov 19;100(22):1592-605. (Highlighted in J Natl Cancer Inst. - Defining a candidate lung cancer gene)

Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol. 2008 Oct;28(19):6104-12.

Fu D, Tian L, Peng Z, Deng W, Yuan J, Ma D, Shi T, Li D, Wang Y. Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells. Biosci Biotechnol Biochem. 2009 Mar 23;73(3):494-501.

Hu Z, Lin D, Yuan J, Xiao T, Zhang H, Sun W, Han N, Ma Y, Di X, Gao M, Ma J, Zhang J, Cheng S, Gao Y. Overexpression of osteopontin is associated with more aggressive phenotypes in human non-small cell lung cancer. Clin Cancer Res. 2005 Jul 1;11(13):4646-52.

Ma Y, Lin D, Sun W, Xiao T, Yuan J, Han N, Guo S, Feng X, Su K, Mao Y, Cheng S and Gao Y.Expression of targeting protein for xklp2 associated both with malignant transformation of respiratory epithelium and progression of squamous cell lung cancer. Clin Cancer Res.2006 Feb 15;12(4):1121-7.

Ma J, Gao M, Lu Y, Feng X, Zhang J, Lin D, Xiao X, Hu Z, Yuan J, Su K, Shipley J, Xue J and Gao Y. Gain of 1q25-32, 12q23-24.3 and 17q12-22 facilitates tumorigenesis and progression of human squamous cell lung cancer. J Pathol. 2006 Oct;210(2):205-13.

Xiao T, Ying W, Li L, Hu Z, Ma Y, Jiao L, Ma J, Cai Y, Lin D, Guo S, Han N, Di X, Li M, Zhang D, Su K, Yuan J, Zheng H, Gao M, He J, Shi S, Li W, Xu N, Zhang H, Liu Y, Zhang K, Gao Y, Qian X, Cheng S. An approach to studying lung cancer-related proteins in human blood. Mol Cell Proteomics. 2005 Oct;4(10):1480-6.

Sun W, Zhang K, Zhang X, Lei W, Xiao T, Ma J, Guo S, Shao S, Zhang H, Liu Y, Yuan J, Hu Z, Ma Y, Feng X, Hu S, Zhou J, Cheng S, Gao Y. Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. Cancer Lett. 2004 Aug 20;212(1):83-93.

Honors and Awards

2015: The NCI Transition Career Development Award (K22)
2014: Susan G. Komen CCR Award
2006: Young Investigator award, the National Cancer Forum for Young Scientists, Hunan, China
2002 - 2005: Excellent Graduate Awards, CAMS&PUMC
2001: Excellent Graduate Awards, Tongji Medical University
2000: United Laboratories Golden Scholarship, Tongji Medical University
1997 - 2001: Excellent Student Awards, Tongji Medical University

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