bio

David J. Brenner, Ph.D.

Higgins Professor of Radiation Biophysics
Director, Center for Radiological Research
Director, Radiological Research Accelerator Facility
Professor of Environmental Health Sciences

Department of Radiation Oncology, Center for Radiological Research
Dept. Environmental Health Sciences, Mailman School of Public Health

Contact Information: 

Center for Radiological Research
630 West 168th Street
New York, NY 10032

Telephone: (212) 305-5660
Fax: 212 305-3229

Email: djb3@cumc.columbia.edu

Website: www.columbia.edu/~djb3

Education

BA, Physics Philosophy, Oxford University, Oxford, U.K., 1974
MSc, Radiation Physics, St. Bartholomew's Hospital, University of London, London, U.K., 1976
MA, Physics Philosophy, Oxford University, Oxford, U.K., 1979
PhD, Physics, University of Surrey, Guildford, U.K., 1980

Research

Dr. Brenner focuses on developing mechanistic models for the effects of ionizing radiation on living systems, both at the chromosomal and the animal (or human) levels. He divides his research time roughly equally between the effects of high doses of ionizing radiation (relating to radiation therapy) and the effects of low doses of radiation (relating to medical, environmental and occupational exposures).

At the chromosomal level, he has focused on the mechanisms of radiation-induced chromosome aberrations, and the potential of chromosome aberrations for use as biomarkers for past exposure to different types of radiations.

In the field of medical imaging, he has focused on the risk / benefit balance of the higher-dose imaging techniques, particularly computed tomography (CT).

In the field of radiotherapy, he has focused on optimizing fractionation schemes for different tumor types, to maximize tumor killing and minimize serious side effects; this includes modeling the mechanisms of radiotherapy-induced second cancers, with the goal of reducing second cancer risks.

Environmentally, he has focused on the biological effects of radon, both at the chromosomal and the human levels.

Selected Activities

Higgins Professor of Radiation Biophysics Director, Center for Radiological Research Director, Radiological Research Accelerator Facility 2012-present    

Member, National Academy of Sciences Nuclear and Radiation Studies Board 1998-2010

Member, National Council on Radiation Protection and Measurements 2002-03

Member, NCRP Committee on Screening of Humans for Security Purposes

Publications

Welch D, Turner L, Speiser M, Randers-Pehrson G, Brenner DJ. Scattered dose calculations and measurements in a life-like mouse phantom. Radiat Res. 2017

Garty G, Xu Y, Elliston C, Marino SA, Randers-Pehrson G, Brenner DJ. Mice and the A-Bomb: Irradiation systems for realistic exposure scenarios. Radiat Res. 2017

Kramer R, Cassola VF, Andrade ME, de Ara├║jo MW, Brenner DJ, Khoury HJ. Mathematical modelling of scanner-specific bowtie filters for Monte Carlo CT dosimetry. Phys Med Biol. 2017;62:781-809

Holmes JA, Chera BS, Brenner DJ, Shuryak I, Wilson AK, Lehman-Davis M, Fried DV, Somasundaram V, Lian J, Cullip T, Marks LB. Estimating the excess lifetime risk of radiation induced secondary malignancy (SMN) in pediatric patients treated with craniospinal irradiation (CSI): Conventional radiation therapy versus helical intensity modulated radiation therapy. Pract Radiat Oncol. 2017;7:35-41

Radivoyevitch T, Sachs RK, Gale RP, Molenaar RJ, Brenner DJ, Hill BT, Kalaycio ME, Carraway HE, Mukherjee S, Sekeres MA, Maciejewski JP Defining AML and MDS second cancer risk dynamics after diagnoses of first cancers treated or not with radiation. Leukemia. 2016;30:285-94

Garty G, Turner HC, Salerno A, et al. The Decade of the RABiT (2005-15). Radiat Prot Dosimetry. July 2016. doi:10.1093/rpd/ncw172.

Buonanno M, Stanislauskas M, Ponnaiya B, et al. 207-nm UV Light-A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. II: In-Vivo Safety Studies. PLoS One. 2016;11(6):e0138418. doi:10.1371/journal.pone.0138418.

Bertucci A, Smilenov LB, Turner HC, Amundson SA, Brenner DJ. In vitro RABiT measurement of dose rate effects on radiation induction of micronuclei in human peripheral blood lymphocytes. Radiat Environ Biophys. 2016 Mar;55(1):53-9. doi: 10.1007/s00411-015-0628-z. Epub 2016 Jan 20.

Helen C. Turner , Igor Shuryak, Waylon Weber, Melanie Doyle-Eisele, Dunstana Melo, Raymond Guilmette, Sally A. Amundson, David J. Brenner. γ-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90. PLOS One. 2015 Nov 30.

Xu Y, Randers-Pehrson G, Marino SA, Garty G, Harken A, Brenner DJ.Broad Energy Range Neutron Spectroscopy using a Liquid Scintillator and a Proportional Counter: Application to a Neutron Spectrum Similar to that from an Improvised Nuclear Device. Nucl Instrum Methods Phys Res A. 2015 Sep 11;794:234-239.

Goudarzi M, Weber WM, Chung J, Doyle-Eisele M, Melo DR, Mak TD, Strawn SJ, Brenner DJ, Guilmette R, Fornace AJ. Serum dyslipidemia is induced by internal exposure to strontium-90 in mice, lipidomic profiling using a data-independent LC/MS approach. J Proteome Res. 2015 Aug 11. [Epub ahead of print]

Lue SW, Repin M, Mahnke R, Brenner DJ. Development of a High-Throughput and Miniaturized Cytokinesis-Block Micronucleus Assay for Use as a Biological Dosimetry Population Triage Tool. Radiat Res. 2015 Jul 31. [Epub ahead of print]

Buonanno M, Randers-Person G, Smilenov LB, Kleiman NJ, Young E, Ponnayia B, Brenner DJ. A Mouse Ear Model for Bystander Studies Induced by Microbeam Irradiation. Radiat Res. 2015 Jul 24. [Epub ahead of print]

Brenner DJ, Chao NJ, Greenberger JS, Guha C, McBride WH, Swartz HM, Williams JP. Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network. Int J Radiat Oncol Biol Phys. 2015 Jul 1.

Shuryak I, Carlson DJ, Brown JM, Brenner DJ. High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients. Radiother Oncol. 2015 Jun 6.

Goudarzi M, Weber WM, Mak TD, Chung J, Doyle-Eisele M, Melo DR, Strawn SJ, Brenner DJ, Guilmette RA, Fornace AJ Jr. A Comprehensive Metabolomic Investigation in Urine of Mice Exposed to Strontium-90. Radiat Res. 2015 Jun. Epub 2015 May 26.

Garty G, Bigelow AW, Repin M, Turner HC, Bian D, Balajee AS, Lyulko OV, Taveras M, Yao YL,Brenner DJ. An automated imaging system for radiation biodosimetry. Microsc Res Tech. 2015 May 4.

Sun H, Olsen T, Zhu J, Tao J, Ponnaiya B, Amundson SA, Brenner DJ, Lin Q. A Bead-Based Microfluidic Approach to Integrated Single-Cell Gene Expression Analysis by Quantitative RT-PCR. RSC Adv. 2015 Jan 1.

Garty G, Ehsan MU, Buonanno M, Yang Z, Sweedler JV, Brenner DJ. MICROBEAM-COUPLED CAPILLARY ELECTROPHORESIS. Radiat Prot Dosimetry. 2015 Apr 12.

Welch D, Harken AD, Randers-Pehrson G, Brenner DJ. Construction of mouse phantoms from segmented CT scan data for radiation dosimetry studies. Phys Med Biol. 2015 May 7. Epub 2015 Apr 10.

Turner HC, Shuryak I, Taveras M, Bertucci A, Perrier JR, Chen C, Elliston CD, Johnson GW, Smilenov LB, Amundson SA, Brenner DJ. Effect of dose rate on residual γ-H2AX levels and frequency of micronuclei in X-irradiated mouse lymphocytes. Radiat Res. 2015 Mar. Epub 2015 Mar 4.

Fazel R, Gerber TC, Balter S, Brenner DJ, Carr JJ, Cerqueira MD, Chen J, Einstein AJ, Krumholz HM, Mahesh M, McCollough CH, Min JK, Morin RL, Nallamothu BK, Nasir K, Redberg RF, Shaw LJ; Approaches to enhancing radiation safety in cardiovascular imaging: a scientific statement from the American Heart Association. Circulation. 2014 Nov 4. Epub 2014 Sep 29.

Xu Y, Zhang B, Messerli M, Randers-Pehrson G, Hei TK, Brenner DJ. Metabolic oxygen consumption measurement with a single-cell biosensor after particle microbeam irradiation.Radiat Environ Biophys. 2015 Mar. Epub 2014 Oct 22.

Goudarzi M, Mak TD, Chen C, Smilenov LB, Brenner DJ, Fornace AJ. The effect of low dose rate on metabolomic response to radiation in mice. Radiat Environ Biophys. 2014 Jul 22.

Brown JM, Carlson DJ, Brenner DJ. Dose escalation, not “new biology,” can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer. In reply to Rao et al. Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):693-4.

Repin M, Turner HC, Garty G, Brenner DJ. Next Generation Platforms for High-throughput Biodosimetry. Radiat Prot Dosimetry. 2014 May 17.

Shuryak I, Lubin JH, Brenner DJ. Potential for Adult-Based Epidemiological Studies to Characterize Overall Cancer Risks Associated with a Lifetime of CT Scans. Radiat Res. 2014 May 14. 

Development of a Metabolomic Radiation Signature in Urine from Patients Undergoing Total Body Irradiation. Radiat Res. 2014 Mar 27.

Lyulko OV, Garty G, Randers-Pehrson G, Turner HC, Szolc B, Brenner DJ. Fast Image Analysis for the Micronucleus Assay in a Fully Automated High-Throughput Biodosimetry System. Radiat Res. 2014 Feb 6.

Turner HC, Sharma P, Perrier JR, Bertucci A, Smilenov L, Johnson G, Taveras M, Brenner DJ, Garty G. The RABiT: high-throughput technology for assessing global DSB repair. Radiat Environ Biophys. 2014 Jan 30. 

Brown JM, Carlson DJ, Brenner DJ. The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved? Int J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):254-62. 

Grad M, Young EF, Smilenov L, Brenner DJ, Attinger D. A simple add-on microfluidic appliance for accurately sorting small populations of cells with high fidelity. J Micromech Microeng. 2013;23(11). 

Goudarzi M, Weber W, Mak TD, Chung J, Doyle-Eisele M, Melo D, Brenner DJ, Guilmette RA, Fornace AJ. Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res. 2014 Jan;181(1):54-64. 

Shuryak I, Smilenov LB, Kleiman NJ, Brenner DJ. Potential reduction of contralateral second breast-cancer risks by prophylactic mammary irradiation: validation in a breast-cancer-prone mouse model. PLoS One. 2013 Dec 20;8(12):e85795. 

Brenner DJ, Vazquez M, Buonanno M, Amundson SA, Bigelow AW, Garty G, Harken AD, Hei TK, Marino SA, Ponnaiya B, Randers-Pehrson G, Xu Y. Integrated interdisciplinary training in the radiological sciences. Br J Radiol. 2014 Feb;87(1034):20130779. 

Brenner DJ. What we know and what we don't know about cancer risks associated with radiation doses from radiological imaging. Br J Radiol. 2014 Jan 20. 

Brenner DJ, Shuryak I, Jozsef G2, Dewyngaert KJ, Formenti SC. Risk and risk reduction of major coronary events associated with contemporary breast radiotherapy. JAMA Intern Med. 2014 Jan;174(1):158-60. 

Buonanno M, Randers-Pehrson G, Bigelow AW, Trivedi S, Lowy FD, Spotnitz HM, Hammer SM, Brenner DJ. 207-nm UV light - a promising tool for safe low-cost reduction of surgical site infections. I: in vitro studies. PLoS One. 2013 Oct 16;8(10):e76968. 

Grad M, Harken A, Randers-Pehrson G, Attinger D, Brenner DJ. An ultra-thin Schottky diode as a transmission particle detector for biological microbeams. J Instrum. 2012 Dec;7. pii: P12001. 

Ponnaiya B, Amundson SA, Ghandhi SA, Smilenov LB, Geard CR, Buonanno M, Brenner DJ. Single-cell responses to ionizing radiation. Radiat Environ Biophys. 2013 Nov;52(4):523-30. 

Buonanno M, Garty G, Grad M, Gendrel M, Hobert O, Brenner DJ. Microbeam irradiation of C. elegans nematode in microfluidic channels. Radiat Environ Biophys. 2013 Nov;52(4):531-7. 

Schissler AJ, Rozenshtein A, Kulon ME, Pearson GD, Green RA, Stetson PD, Brenner DJ, D'Souza B, Tsai WY, Schluger NW, Einstein AJ. CT pulmonary angiography: increasingly diagnosing less severe pulmonary emboli. PLoS One. 2013 Jun 12;8(6):e65669.

Lyulko OV, Randers-Pehrson G, Brenner DJ. Simultaneous immersion Mirau interferometry. Rev Sci Instrum. 2013 May;84(5):053701. 

Manuela Buonanno, Gerhard Randers-Pehrson, Alan W. Bigelow, Sheetal Trivedi, Franklin D. Lowy, Henry M. Spotnitz, Scott M. Hammer, David J. Brenner. 207-nm UV Light - A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. I: In Vitro Studies. Plos One, Vol. 8 Iss. 10. Oct 2013.

Brown JM, Brenner DJ, Carlson DJ. Dose escalation, not "new biology," can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):1159-60.

Xu Y, Turner HC, Garty G, Brenner DJ. A Rapid, Quantitative Method to Characterize The Human Lymphocyte Concentration for Automated High-Throughput Radiation Biodosimetry. Biomed. Eng. Res. Vol. 2 Iss. 1 PP. 16-19, March (2013).

Grad, M., Bigelow, A.W., Garty, G., Attinger, D. and Brenner D.J. Optofluidic cell manipulation for a biological microbeam. Rev. Sci. Instrum. 84: 014301 (2013).

Brenner DJ. Radiation and chest CT scans: are there problems? What should we do? Chest 142:549-50 (2012)

Brenner DJ. Minimizing medically unwarranted computed tomography scans. Ann ICRP. 41:161-9 (2012).

Brenner DJ. We can do better than effective dose for estimating or comparing low-dose radiation risks. Ann ICRP. 41:124-8 (2012).

Brenner DJ, Hall EJ. Cancer Risks from CT Scans: Now We Have Data, What Next? Radiology. 265:330-1 (2012).

Brenner DJ. Exploring two two-edged swords. Radiat Res. 178:7-16 (2012).

Shuryak I, Brenner DJ. Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death. Radiat Res. 178:17-24 (2012).

Becker SJ, Elliston CD, Dewyngaert K, Jozsef G, Brenner DJ, Formenti S. Breast radiotherapy in the prone position primarily reduces the maximum out-of-field measured dose to the ipsilateral lung. Med Phys. 39:2417-23 (2012).

Chen Y, Wang H, Zhang J, Garty G, Simaan N, Yao YL, Brenner DJ. Automated recognition of robotic manipulation failures in high-throughput biodosimetry Tool. Expert Syst Appl. 39:9602-11 (2012).

Milne EN, Brenner DJ, Shuryak I, Einstein AJ. The older, the better. Radiology. 263(1):306-7 (2012).

Brenner DJ, Sachs RK, Peters LJ, Withers HR, Hall EJ. We forget at our peril the lessons built into the α/β model. Int J Radiat Oncol Biol Phys. 82(4):1312-4 (2012).

Ng J, Shuryak I, Xu Y, Clifford Chao KS, Brenner DJ, Burri RJ. Predicting the Risk of Secondary Lung Malignancies Associated with Whole-Breast Radiation Therapy. Int J Radiat Oncol Biol Phys. Epub: Jan 13 (2012).

For a complete list of publications with links please visit: http://www.columbia.edu/~djb3/publications.html

Honors and Awards

DSc, Honorary Degree, Oxford University, 1996
Failla Award, Radiation Research Society, 2011

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