bio

Igor Shuryak, MD/PhD.

Assistant Professor

Center for Radiological Research

Contact Information: 

 

630 West 168th Street
New York, NY 10032

Telephone: (212) 305-2405

Email: 

is144@cumc.columbia.edu

 

Education

BA, Biology and Environmental Sciences, Columbia University, New York, U.S., 1997

MD, Medicine, SUNY Downstate College of Medicine, New York, U.S., 2001

PhD, Environmental Health Sciences, Columbia University, New York, U.S., 2010

Research

My main research focus involves quantitatively modeling and preventing radiation-induced carcinogenesis. My other interests include understanding and modeling other biological effects of ionizing radiation, including radioresistance and non-targeted effects. My previous training and experience have been interdisciplinary, starting with biology (BA from Columbia University) and medicine (MD from SUNY Downstate College of Medicine). I completed the intensive Cancer Training Program (Columbia University, Mailman School of Public Health), where for three years I improved my skills in cancer epidemiology and biostatistics. I received a PhD degree with distinction in 2010 from the department of Environmental Health Sciences (Columbia University, Mailman School of Public Health) for mechanistic mathematical modeling of radiation-induced carcinogenesis. 

 

Publications

1. Sharma A, Gaidamakova EK, Grichenko O, Matrosova VY, Hoeke V, Klimenkova P, Conze IH, Volpe RP, Tkavc R, GostinĨar C, Gunde-Cimerman N, DiRuggiero J, Shuryak I, Ozarowski A, Hoffman BM, Daly MJ. Across the tree of tife, radiation resistance is governed by antioxidant Mn2+, gauged by paramagnetic resonance. PNAS 2017 [In press].


2. Malo ME, Bryan RA, Shuryak I, Dadachova E. Morphological changes in melanized and non-melanized Cryptococcus neoformans cells post exposure to sparsely and densely ionizing radiation demonstrate protective effect of melanin. Fungal Biology. 2017 [Epub ahead of print].


3. Cornforth M, Shuryak I, Loucas B. Lethal and nonlethal chromosome aberrations by gamma rays and heavy ions: a cytogenetic perspective on dose fractionation in hadron radiotherapy. Translational Cancer Research. 2017 6:S770-78.


4. Shuryak I. Quantitative modeling of responses to chronic ionizing radiation exposure using targeted and non-targeted effects. PLoS One. 2017 12:e0176476.


5. Shuryak I, Fornace AJ Jr, Datta K, Suman S, Kumar S, Sachs RK, Brenner DJ. Scaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex. Radiat Res. 2017 187:476-482.


6. Pacelli C, Bryan RA, Onofri S, Selbmann L, Shuryak I, Dadachova E. Melanin is effective in protecting fast and slow growing fungi from various types of ionizing radiation. Environ Microbiol. 2017 19:1612-1624.


7. Pacelli C, Selbmann L, Zucconi L, Raguse M, Moeller R, Shuryak I, Onofri S. Survival, DNA Integrity, and Ultrastructural Damage in Antarctic Cryptoendolithic Eukaryotic Microorganisms Exposed to Ionizing Radiation. Astrobiology. 2017 17:126-135.


8. Vandermolen J, Einstein A, Shuryak I, Balter S, Meulepas J, King R, Mehta N, Brenner DJ, Gehi A. Estimating Cancer Risk Assciated with Ionizing Radiation Exposure During Atrial Fibrillation Ablation. J Amer Coll Cardiol. 2017 69:502.


9. Ivanidze J, Charalel RA, Shuryak I, Brenner D, Pandya A, Kallas ON, Kesavabhotla K, Segal AZ, Simon MS, Sanelli PC. Effects of Radiation Exposure on the Cost-Effectiveness of CT Angiography and Perfusion Imaging in Aneurysmal Subarachnoid Hemorrhage. AJNR Am J Neuroradiol. 2017 38:462-468.


10. Shuryak I. Advantages of Synthetic Noise and Machine Learning for Analyzing Radioecological Data Sets. PLoS One. 2017 12:e0170007.


11. Shuryak I, Loucas BD, Cornforth MN. Seeking Beta: Experimental Considerations and Theoretical Implications Regarding the Detection of Curvature in Dose-Response Relationships for Chromosome Aberrations. Radiat Res. 2017 187:7-19.


12. Holmes JA, Chera BS, Brenner DJ, Shuryak I, Wilson AK, Lehman-Davis M, Fried DV, Somasundaram V, Lian J, Cullip T, Marks LB. Estimating the excess lifetime risk of radiation induced secondary malignancy (SMN) in pediatric patients treated with craniospinal irradiation (CSI): Conventional radiation therapy versus helical intensity modulated radiation therapy. Pract Radiat Oncol. 2017 7:35-41.


13. Buonanno M, Stanislauskas M, Ponnaiya B, Bigelow AW, Randers-Pehrson G, Xu Y, Shuryak I, Smilenov L, Owens DM, Brenner DJ. 207-nm UV Light-A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. II: In-Vivo Safety Studies. PLoS One. 2016 11:e0138418.


14. Loucas BD, Shuryak I, Cornforth MN. Three-Color Chromosome Painting as Seen through the Eyes of mFISH: Another Look at Radiation-Induced Exchanges and Their Conversion to Whole-Genome Equivalency. Front Oncol. 2016 6:52.


15. Shuryak I, Sun Y, Balajee AS. Advantages of Binomial Likelihood Maximization for Analyzing and Modeling Cell Survival Curves. Radiat Res. 2016 185:246-256.


16. Shuryak I, Dadachova E. Quantitative Modeling of Microbial Population Responses to Chronic Irradiation Combined with Other Stressors. PLoS One. 2016 11:e0147696.


17. Shuryak I. Mechanistic Modeling of Dose and Dose Rate Dependences of Radiation-Induced DNA Double Strand Break Rejoining Kinetics in Saccharomyces cerevisiae. PLoS One. 2016 11:e0146407.


18. Turner HC, Shuryak I, Weber W, Doyle-Eisele M, Melo D, Guilmette R, Amundson SA, Brenner DJ. γ-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90. PLoS One. 2015 10:e0143815.


19. Shuryak I, Dadachova E. New Approaches for Modeling Radiopharmaceutical Pharmacokinetics Using Continuous Distributions of Rates. J Nucl Med. 2015 56:1622-1628.


20. Herr L, Shuryak I, Friedrich T, Scholz M, Durante M, Brenner DJ. New Insight into Quantitative Modeling of DNA Double-Strand Break Rejoining. Radiat Res. 2015 184:280-295.


21. Sharma PM, Ponnaiya B, Taveras M, Shuryak I, Turner H, Brenner DJ. Correction: High Throughput Measurement of γH2AX DSB Repair Kinetics in a Healthy Human Population. PLoS One. 2015 10:e0131620.


22. Shuryak I, Carlson DJ, Brown JM, Brenner DJ. High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients. Radiother Oncol. 2015 115:327-334.


23. Shuryak I, Bryan RA, Broitman J, Marino SA, Morgenstern A, Apostolidis C, Dadachova E. Effects of radiation type and delivery mode on a radioresistant eukaryote Cryptococcus neoformans. Nucl Med Biol. 2015 42:515-523.


24. Sharma PM, Ponnaiya B, Taveras M, Shuryak I, Turner H, Brenner DJ. High throughput measurement of γH2AX DSB repair kinetics in a healthy human population. PLoS One. 2015 10:e0121083.


25. Turner HC, Shuryak I, Taveras M, Bertucci A, Perrier JR, Chen C, Elliston CD, Johnson GW, Smilenov LB, Amundson SA, Brenner DJ. Effect of dose rate on residual γ-H2AX levels and frequency of micronuclei in X-irradiated mouse lymphocytes. Radiat Res. 2015 183:315-324.


26. Ng J, Shuryak I. Minimizing second cancer risk following radiotherapy: current perspectives. Cancer Manag Res. 2014 7:1-11.


27. Shuryak I, Lubin JH, Brenner DJ. Potential for adult-based epidemiological studies to characterize overall cancer risks associated with a lifetime of CT scans. Radiat Res. 2014 181:584-591.


28. Shuryak I, Bryan RA, Nosanchuk JD, Dadachova E. Mathematical modeling predicts enhanced growth of X-ray irradiated pigmented fungi. PLoS One. 2014 9:e85561.


29. Brenner DJ, Shuryak I, Jozsef G, Dewyngaert KJ, Formenti SC. Risk and risk reduction of major coronary events associated with contemporary breast radiotherapy. JAMA Intern Med. 2014 174:158-160.


30. Shuryak I, Smilenov LB, Kleiman NJ, Brenner DJ. Potential reduction of contralateral second breast-cancer risks by prophylactic mammary irradiation: validation in a breast-cancer-prone mouse model. PLoS One. 2013 8:e85795.


31. Ng J, Shuryak I, Xu Y, Clifford Chao KS, Brenner DJ, Burri RJ. Predicting the risk of secondary lung malignancies associated with whole-breast radiation therapy. Int J Radiat Oncol Biol Phys. 2012 83:1101-1106.


32. Shuryak I, Brenner DJ. Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death. Radiat Res. 2012 178:17-24.


33. Brenner DJ, Shuryak I. Ten years of follow-up is not long enough to assess lifetime cancer risks caused by computed tomography scans in a young population. J Clin Oncol. 2011 29:4062.


34. Brenner DJ, Shuryak I, Einstein AJ. Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging. Radiology. 2011 261:193-198.


35. Turner HC, Brenner DJ, Chen Y, Bertucci A, Zhang J, Wang H, Lyulko OV, Xu Y, Shuryak I, Schaefer J, Simaan N, Randers-Pehrson G, Yao YL, Amundson SA, Garty G. Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects. Radiat Res. 2011 175:282-290.


36. Shuryak I, Sachs RK, Brenner DJ. A new view of radiation-induced cancer. Radiat Prot Dosimetry. 2011 143:358-364.


37. Shuryak I, Brenner DJ, Ullrich RL. Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA. PLoS One. 2011 6:e28559.


38. Shuryak I, Sachs RK, Brenner DJ. Cancer risks after radiation exposure in middle age. J Natl Cancer Inst. 2010 102:1628-1636.


39. Shuryak I, Brenner DJ. Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans. Radiat Environ Biophys. 2010 49:693-703.


40. Shuryak I, Ullrich RL, Sachs RK, Brenner DJ. The balance between initiation and promotion in radiation-induced murine carcinogenesis. Radiat Res. 2010 174:357-366.


41. Shuryak I, Brenner DJ. A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. J Theor Biol. 2009 261:305-317.


42. Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys. 2009 48:275-286.


43. Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat Environ Biophys. 2009 48:263-274.


44. Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 249:518-531.


45. Shuryak I, Sachs RK, Brenner DJ. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat Res. 2007 168:741-749.


46. Brenner DJ, Shuryak I, Russo S, Sachs RK. Reducing second breast cancers: a potential role for prophylactic mammary irradiation. J Clin Oncol. 2007 25:4868-4872.


47. Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ. Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst. 2006 98:1794-1806.
 

Honors and Awards

2011 - Radiation Research Editor's Award, Radiation Research Society
2014 - Radiation Research Jack Fowler Award, Radiation Research Society

 

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