bio

Igor Shuryak, MD/PhD.

Assistant Professor

Center for Radiological Research

Contact Information: 

 

630 West 168th Street
New York, NY 10032

Telephone: (212) 305-2405

Email: 

is144@cumc.columbia.edu

 

Education

BA, Biology and Environmental Sciences, Columbia University, New York, U.S., 1997

MD, Medicine, SUNY Downstate College of Medicine, New York, U.S., 2001

PhD, Environmental Health Sciences, Columbia University, New York, U.S., 2010

Research

My main research focus involves quantitatively modeling and preventing radiation-induced carcinogenesis. My other interests include understanding and modeling other biological effects of ionizing radiation, including radioresistance and non-targeted effects. My previous training and experience have been interdisciplinary, starting with biology (BA from Columbia University) and medicine (MD from SUNY Downstate College of Medicine). I completed the intensive Cancer Training Program (Columbia University, Mailman School of Public Health), where for three years I improved my skills in cancer epidemiology and biostatistics. I received a PhD degree with distinction in 2010 from the department of Environmental Health Sciences (Columbia University, Mailman School of Public Health) for mechanistic mathematical modeling of radiation-induced carcinogenesis. 

 

Publications

Mechanistic mathematical modeling of radiation-induced carcinogenesis, particularly second cancers induced by radiotherapy in patients treated for primary tumors
Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ. Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst. 2006 Dec 20;98(24):1794-806. PubMed PMID: 17179481.

Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat Environ Biophys. 2009 Aug;48(3):263-74. PubMed PMID: 19536557; PubMed Central PMCID: PMC2714893.

Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys. 2009 Aug;48(3):275-86. PubMed PMID: 19499238; PubMed Central PMCID: PMC2714894.

Shuryak I, Sachs RK, Brenner DJ. Cancer risks after radiation exposure in middle age. J Natl Cancer Inst. 2010 Nov 3;102(21):1628-36. PubMed PMID: 20975037; PubMed Central PMCID: PMC2970575.

Experimental and theoretical research to identify novel approaches to prevent cancer in humans
Brenner DJ, Shuryak I, Russo S, Sachs RK. Reducing second breast cancers: a potential role for prophylactic mammary irradiation. J Clin Oncol. 2007 Nov 1;25(31):4868-72. PubMed PMID: 17971581.

Shuryak I, Smilenov LB, Kleiman NJ, Brenner DJ. Potential reduction of contralateral second breast-cancer risks by prophylactic mammary irradiation: validation in a breast-cancer-prone mouse model. PLoS One. 2013;8(12):e85795. PubMed PMID: 24376895; PubMed Central PMCID: PMC3869887.

Mathematical modeling of the mechanisms of resistance to ionizing radiation
Shuryak I. Advantages of Synthetic Noise and Machine Learning for Analyzing Radioecological Data Sets. PLoS One. 2017;12(1):e0170007. PubMed PMID: 28068401; PubMed Central PMCID: PMC5222373.

Shuryak I, Dadachova E. Quantitative Modeling of Microbial Population Responses to Chronic Irradiation Combined with Other Stressors. PLoS One. 2016;11(1):e0147696. PubMed PMID: 26808049; PubMed Central PMCID: PMC4726741.

Shuryak I, Brenner DJ. Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans. Radiat Environ Biophys. 2010 Nov;49(4):693-703. PubMed PMID: 20574841.

Shuryak I, Brenner DJ. A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. J Theor Biol. 2009 Nov 21;261(2):305-17. PubMed PMID: 19679136; PubMed Central PMCID: PMC2774503.

Quantification of the risks of cancer and other diseases (particularly cardiovascular disease) in patients exposed to ionizing radiation during therapeutic or diagnostic medical procedures

Ivanidze J, Charalel RA, Shuryak I, Brenner D, Pandya A, Kallas ON, Kesavabhotla K, Segal AZ, Simon MS, Sanelli PC. Effects of Radiation Exposure on the Cost-Effectiveness of CT Angiography and Perfusion Imaging in Aneurysmal Subarachnoid Hemorrhage. AJNR Am J Neuroradiol. 2017 Mar;38(3):462-468. PubMed PMID: 28082263.

Ng J, Shuryak I. Minimizing second cancer risk following radiotherapy: current perspectives. Cancer Manag Res. 2015;7:1-11. PubMed PMID: 25565886; PubMed Central PMCID: PMC4274043.

Shuryak I, Lubin JH, Brenner DJ. Potential for adult-based epidemiological studies to characterize overall cancer risks associated with a lifetime of CT scans. Radiat Res. 2014 Jun;181(6):584-91. PubMed PMID: 24828111; PubMed Central PMCID: PMC4157352.

Brenner DJ, Shuryak I, Einstein AJ. Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging. Radiology. 2011 Oct;261(1):193-8. PubMed PMID: 21771956.

Mechanistic mathematical modeling of non-targeted ("bystander") effects of ionizing radiation, including their role in radiation carcinogenesis
Shuryak I. Advantages of Synthetic Noise and Machine Learning for Analyzing Radioecological Data Sets. PLoS One. 2017;12(1):e0170007. PubMed PMID: 28068401; PubMed Central PMCID: PMC5222373.

Shuryak I, Loucas BD, Cornforth MN. Seeking Beta: Experimental Considerations and Theoretical Implications Regarding the Detection of Curvature in Dose-Response Relationships for Chromosome Aberrations. Radiat Res. 2017 Jan;187(1):7-19. PubMed PMID: 28085640.

Shuryak I, Brenner DJ, Ullrich RL. Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA. PLoS One. 2011;6(12):e28559. PubMed PMID: 22194850; PubMed Central PMCID: PMC3237439.

Shuryak I, Sachs RK, Brenner DJ. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat Res. 2007 Dec;168(6):741-9. PubMed PMID: 18088188.
 

Honors and Awards

2011 - Radiation Research Editor's Award, Radiation Research Society
2014 - Radiation Research Jack Fowler Award, Radiation Research Society

 

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